Reposted by Will Allen
Check out this preprint on Perturb-multi (doi.org/10.1101/2024...), a multi-year collaborative effort that enabled multi-modal in vivo genotype-phenotype mapping by pooled genetic perturbations and high-dimensionality phenotype readout by imaging and sequencing.
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doi.org
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function
Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the...
