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Tony McChrystal

@tonymac5.bsky.social
273 followers 833 following 114 posts

Freshly parachuted in from the cesspit formerly known as Twitter. Still hoping Everton become less poo, loving science and all things biology. Be kind or I'll batter yous all.

PostsRepliesMedia
Tony McChrystal @tonymac5.bsky.social · 24/02/2025
phys.org/news/2025-02...
phys.org
Innovative microscope reveals full 3D molecular orientation in cells
Two heads are better than one, as the saying goes, and sometimes two instruments, ingeniously recombined, can accomplish feats that neither could have done on its own.
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Tony McChrystal @tonymac5.bsky.social · 13/02/2025
www.nature.com/articles/s41...
nature.com
Intratumoral administration of mRNA COVID-19 vaccine delays melanoma growth in mice - Scientific Reports
Scientific Reports - Intratumoral administration of mRNA COVID-19 vaccine delays melanoma growth in mice
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Tony McChrystal @tonymac5.bsky.social · 10/02/2025
medicalxpress.com/news/2025-02... Some of the advances in autoimmune conditions such as this may bring real benefits soon, hopefully. There's also the continuing work on 'inverse vaccines' against autoimmune diseases. www.cas.org/resources/ca...
medicalxpress.com
Researchers discover a major driver of inflammatory pathology in autoimmune and chronic inflammatory diseases
Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system—a group of proteins that pat...
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Tony McChrystal @tonymac5.bsky.social · 10/02/2025
advanced.onlinelibrary.wiley.com/doi/10.1002/... More scary* mRNA delivery advances. *exciting.
advanced.onlinelibrary.wiley.com
A Serum Resistant Polymer with Exceptional Endosomal Escape and mRNA Delivery Efficacy for CRISPR Gene Therapy
A fluoropolymer, FD17, identified in a polymer library, exhibits exceptional serum stability and endosomal escape, enabling efficient mRNA delivery. FD17 facilitates the intracellular delivery of mRN...
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Tom Gauld @tomgauld.bsky.social · 10/02/2025
My latest cartoon for @newscientist.com
Two figures walk along a corridor lined with complex machinery. 

The worker says "Congratulations, sir! The most intelligent machine ever created is ready to change the world. Ten billion dollars well spent...  What shall we ask it to do? "

The billionaire replies "That's my business, not yours. Close the door on your way out."

Now alone with the machine, the billionaire asteps closer and asks quietly "Can you Make people like me?"
it says "No"
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John Topham @johntopham.bsky.social · 10/02/2025
This could help a lot of people if it works out medicalxpress.com/news/2025-02...
medicalxpress.com
Researchers discover a major driver of inflammatory pathology in autoimmune and chronic inflammatory diseases
Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system—a group of proteins that pat...
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Reposted by Tony McChrystal
Luciano A. Masullo @lumasullo.bsky.social · 10/02/2025
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1...
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Angie Rasmussen @angierasmussen.bsky.social · 09/02/2025
Editing scientific content for political purity is turning MMWR into a compromised propaganda organ. And why are the propaganda squads at CDC replacing specifically H5N1 bird flu studies? I’ve got some pretty serious fascism- and flu-related concerns about this.
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Andrea Luck @andrealuck.bsky.social · 09/02/2025
Cool image of clouds over the Northern Hemisphere of Mars taken by CNSA's Tianwen 1 Full size & more info: flic.kr/p/2qKEu4g Image Processing: Andrea Luck Raw Image: CNSA/CLEP/PEC/MoRIC 2024-01-27 at 3230 km From the left: Milankovic Crater, Alba Mons and Tempe Terra North is up
A view of Mars from orbit over the northern hemisphere with swirling clouds stretching across the planet’s surface. These clouds appear wispy and layered, with subtle wave like patterns. They are denser near the terminator, where they take on a soft, diffused appearance, gradually thinning toward the illuminated regions. Near the center, the broad, circular Alba Mons is visible. The upper part of the image marks the terminator, while the lower part reveals Mars atmospheric limb.
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Pearl Freier @pearlf.bsky.social · 08/02/2025
If you have encountered pediatric interdigitating dendritic cell sarcoma (IDCS), indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases—please see short thread below & reach out to Sri Kosuri: #sarcoma #medsky #biosky
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Tony McChrystal @tonymac5.bsky.social · 08/02/2025
Honestly, if this keeps going, it will be the single biggest, stupidest, most damaging self-inflicted wound any country has ever inflicted on itself.
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East Anglia Bylines @eastangliabylines.co.uk · 08/02/2025
Homelessness. 160,000 children in temporary accommodation. Lack of permanent home contributing factor in death of 74 (if not many more) kids since 2019. 39,000 families & pensioners placed out of borough. All @privateeyenews.bsky.social figures. The St Albans exhibition is a timely reminder...
eastangliabylines.co.uk
Outsiders exposed: powerful photos reveal the ruthless reality of homelessness
A striking exhibition in St Albans reveals the harsh realities of homelessness through powerful black-and-white photography
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Davenant 📸 @marcdavenant.bsky.social · 08/02/2025
Loise from the Outsiders project. She spent fours years sleeping rough in London with her baby, afraid of trying to get support due to the hostile environment. They lived on scraps of discarded food from bins, or which had been dropped on the ground.
Front cover of Big Issue magazine with a woman holding a baby which is looking at the camera
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Tony McChrystal @tonymac5.bsky.social · 08/02/2025
Went to see Companion earlier this week. Good thriller, some heavy sci-fi themes handled adeptly, with black humour and excellent action. Sophie Thatcher was amazing.
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The Dread Duck Pirate Mark Brooks @markbrooksart.bsky.social · 08/02/2025
Well shit.
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STITCHES Medicine - the Best of Medical Research @medicine.stitches.today · 08/02/2025
A novel CAR T-cell therapy achieved an 82% response rate in lymphoma patients, demonstrating efficacy even at low doses. by Park JH, Palomba ML (...) Sadelain M et 31 al. in J Clin Oncol #MedSky 📖 read the article: ascopubs.org/doi/10.1200/JCO-24-024…
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Louise Matsakis @lmatsakis.bsky.social · 07/02/2025
SCOOP: FBI director nominee Kash Patel disclosed he received up to $5M in shares of a mysterious entity in the Cayman Islands called Elite Depot. Elite Depot is a parent organization of fast-fashion giant Shein, according to corporate records I reviewed www.wired.com/story/kash-p...
wired.com
Trump's FBI Pick Kash Patel Took Up to $5M in Stock from Chinese Ecommerce Giant Shein
Donald Trump’s pick for FBI director told senators he has no plans to divest his shares, which his financial disclosure form says were received in exchange for consulting services.
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Leo Lam, Ph.D.💉⚕️🌎 @drleolam.bsky.social · 08/02/2025
The N.I.H. will cut about $4 Billion from federal research grants that support cancer, virus and heart disease research. This is a direct attack on science, and America's leadership in medical innovation. This is the kind of "winning" they want? Seriously?
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WIRED @wired.com · 07/02/2025
SCOOP: A US Treasury threat intelligence analysis has designated DOGE staff an ‘insider threat'. An internal email reviewed by WIRED calls DOGE staff's access to federal payments systems “the single biggest insider threat risk the Bureau of the Fiscal Service has ever faced.”
wrd.cm
A US Treasury Threat Intelligence Analysis Designates DOGE Staff as ‘Insider Threat’
An internal email reviewed by WIRED calls DOGE staff's access to federal payments systems “the single biggest insider threat risk the Bureau of the Fiscal Service has ever faced.”
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Reposted by Tony McChrystal
𝚜𝚝𝚎𝚙𝚑𝚊𝚗𝚒𝚎✩ @allmylovesteph.bsky.social · 08/02/2025
BREAKING: A federal judge has blocked Elon Musk’s DOGE from accessing sensitive US Treasury Department material. He set a hearing for February 14th.
apnews.com
Federal judge blocks Elon Musk's DOGE from accessing sensitive US Treasury Department material
Those records contain personal data such as Social Security and bank account numbers for millions of Americans.
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Tony McChrystal @tonymac5.bsky.social · 08/02/2025
advanced.onlinelibrary.wiley.com/doi/10.1002/... This is fascinating research. Probably a long time till any treatment is possible, but reverting cancerous cells to healthy cells would be amazing.
advanced.onlinelibrary.wiley.com
Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis
REVERT (REVERse Transition) is presented, a systems framework developed to identify a reversion switch in the transition process of tumorigenesis through comprehensive attractor landscape analysis of...
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Corey S. Powell @coreyspowell.bsky.social · 28/01/2025
You've probably heard that "we are stardust," but this graphic breaks it down and tells you what kind of stars your dust came from--and which elements didn't come from stars at all. 🧪 svs.gsfc.nasa.gov/13873/
This periodic table depicts the primary source on Earth for each element: from the Big Bang, massive stars, white-dwarf supernovae, merging neutron stars, low-mass stars, or other processes. In cases where two sources contribute fairly equally, both appear.
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Charlie Warzel @cwarzel.bsky.social · 07/02/2025
New: We spoke to government IT employees/contractors about DOGE. Their warnings were dire. The people who maintain the systems that keep the country working are terrified. "This is the largest data breach and the largest IT security breach in our country’s history—at least that’s publicly known."
theatlantic.com
The Government’s Computing Experts Say They Are Terrified
Four IT professionals lay out just how destructive Elon Musk’s incursion into the U.S. government could be.
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Tony McChrystal @tonymac5.bsky.social · 07/02/2025
Actions are going to meet consequences. Unfortunately, with infectious diseases and anti-vaxxers, it's usually the most vulnerable who face those consequences.
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Tony McChrystal @tonymac5.bsky.social · 06/02/2025
Interesting pronunciation of Ryan Gravenberch.
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NeuroJoe @neurojoe.bsky.social · 06/02/2025
My wife is an NIH funded scientist primary investigator on the CRISPR For Cure HIV program. The goal is to use gene editing to inactivate HIV and produce a functional AIDS cure. She was ordered by an NIH program officer to take down the website last week. Their future funding is in dire straits.
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Tony McChrystal @tonymac5.bsky.social · 06/02/2025
I know it can a teensy bit annoying for power mad autocrats and democratic governments alike, but the rule of law is there for a reason. Hopefully, America will find out sooner rather than later.
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Tony McChrystal @tonymac5.bsky.social · 05/02/2025
It's okay, they'll just stop funding the testing and proclaim that the outbreak is over. DOGE for the win! 🤪
media.tenor.com
a cartoon character sitting on a couch with the words im totally not crazy you can trust me
ALT: a cartoon character sitting on a couch with the words im totally not crazy you can trust me
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Emily Mullin @emilymullin.bsky.social · 05/02/2025
Hi all, I'm a WIRED journalist on the science desk. If you're a government scientist or federally funded researcher with info to share about the Trump transition, please feel free to contact me securely on Signal: emullin.06
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Tony McChrystal @tonymac5.bsky.social · 05/02/2025
www.science.org/doi/10.1126/...
science.org
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.
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Kristian G. Andersen @kgandersen.bsky.social · 05/02/2025
Genotype D1.1 of H5N1 confirmed in Nevada cattle, which is the one circulating in birds and not B3.13, causing the wider cattle epizootic in the U.S. In other words, this is a second observed jump from birds into cows. Keep rolling the dice, shall we? www.feedstuffs.com/agribusiness...
feedstuffs.com
New HPAI genotype found in Nevada dairy cows
APHIS confirms first detection of D1.1 genotype in dairy cattle through NMTS testing.
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Tony McChrystal @tonymac5.bsky.social · 05/02/2025
medicalxpress.com/news/2025-02... Potentially great news, positive results from a phase 1 trial of personalised cancer vaccines post-surgery.
medicalxpress.com
Cancer vaccine shows promise for patients with stage III and IV kidney cancer
Dana-Farber Cancer Institute researchers report that all nine patients in a clinical trial being treated for stage III or IV clear cell renal cell carcinoma (a form of kidney cancer), generated a succ...
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Tony McChrystal @tonymac5.bsky.social · 05/02/2025
phys.org/news/2025-02...
phys.org
Active agent against cancer metastasis discovered: Adhibin prevents migration and attachment to other cells
Every cell in the body normally has its fixed place as part of a tissue structure. Except for a few cell types, such as blood or immune cells. But cancer cells also cross established boundaries, grow ...
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Tony McChrystal @tonymac5.bsky.social · 05/02/2025
Not sure of the choice for the big enemy in the new Fantastic Four film.
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Tony McChrystal @tonymac5.bsky.social · 04/02/2025
Unlucky knobheads.😂
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spaminthelab.bsky.social @spaminthelab.bsky.social · 04/02/2025
Due to the freeze on credit card use, my laboratory (in the FDA) risks losing the contents of our liquid nitrogen tanks which store INVALUABLE samples-they cannot be replaced, so they are literally priceless, and reflect about 50 years worth of research.
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🗽LOLGOP🗽 @lolgop.bsky.social · 04/02/2025
"I just want to be clear about what's going on here." - @warren.senate.gov www.youtube.com/watch?v=RIHN...
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Jessica Elgot @jessicaelgot.bsky.social · 04/02/2025
Kyrke-Smith says perinatal mental health care in England is ‘postcode lottery’, with disadvantaged women more likely to miss out www.theguardian.com/society/2025...
theguardian.com
Labour MP to push for better maternal mental health care after friend’s suicide
Laura Kyrke-Smith says perinatal mental health care in England is ‘postcode lottery’, with disadvantaged women more likely to miss out
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Tony McChrystal @tonymac5.bsky.social · 04/02/2025
medicalxpress.com/news/2025-02...
medicalxpress.com
Research discovery halts childhood brain tumor before it forms
Scientists at The Hospital for Sick Children (SickKids) have discovered a way to stop tumor growth before it starts for a subtype of medulloblastoma, the most common childhood malignant brain cancer.
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Tony McChrystal @tonymac5.bsky.social · 04/02/2025
I wish Labour would pull their finger out. Still falling in to the old traps of timidity because they're too scared of Reform and Brexit. Get a closer relationship with the EU, get the economic benefits and shut Farage and Co up. They've got four years till they have to worry about elections.
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Tony McChrystal @tonymac5.bsky.social · 04/02/2025
medicalxpress.com/news/2025-02...
medicalxpress.com
Potential new therapy for childhood brain cancer could heal treatment-resistant tumors
Brain cancer is the second-leading cause of death in children in the developed world. For the children who survive, standard treatments have long-term impacts on their development and quality of life,...
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Tony McChrystal @tonymac5.bsky.social · 04/02/2025
The consequences of this insane appointment are on the quislings who voted to advance this grifting, demented huckster.
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Marvin Tanenbaum @marvintanenbaum.bsky.social · 03/02/2025
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation www.cell.com/cell/fulltex...
cell.com
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
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Tony McChrystal @tonymac5.bsky.social · 03/02/2025
I feel that the 'This is fine' meme is getting a good workout today, thanks to events over the Atlantic.
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Tony McChrystal @tonymac5.bsky.social · 02/02/2025
One can only assume at this point that the USA has voted for the worst possible people to ever be in charge of the USA.
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Tony McChrystal @tonymac5.bsky.social · 02/02/2025
Humanity keeps inventing many wonderful, brilliant things. And then, straight away, humanity keeps kicking those things in the bollocks and making things worse for other bits of humanity.
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Alt National Park Service @altnps.bsky.social · 02/02/2025
Please share: We’ve received word that Elon Musk’s staffers are using space characters to identify information leakers. Before sharing any information, please use a checker to detect and remove these.
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Tony McChrystal @tonymac5.bsky.social · 02/02/2025
Installed DeepSeek on a whim, then asked it about Tianemen Square, then uninstalled it fairly quickly. May give OpenAI mini a shot.
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