Tony McChrystal @tonymac5.bsky.social · 24/02/2025phys.org/news/2025-02...phys.orgInnovative microscope reveals full 3D molecular orientation in cellsTwo heads are better than one, as the saying goes, and sometimes two instruments, ingeniously recombined, can accomplish feats that neither could have done on its own. 020
Tony McChrystal @tonymac5.bsky.social · 13/02/2025www.nature.com/articles/s41...nature.comIntratumoral administration of mRNA COVID-19 vaccine delays melanoma growth in mice - Scientific ReportsScientific Reports - Intratumoral administration of mRNA COVID-19 vaccine delays melanoma growth in mice 010
Tony McChrystal @tonymac5.bsky.social · 10/02/2025medicalxpress.com/news/2025-02... Some of the advances in autoimmune conditions such as this may bring real benefits soon, hopefully. There's also the continuing work on 'inverse vaccines' against autoimmune diseases. www.cas.org/resources/ca...medicalxpress.comResearchers discover a major driver of inflammatory pathology in autoimmune and chronic inflammatory diseasesOur immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system—a group of proteins that pat... 010
Tony McChrystal @tonymac5.bsky.social · 10/02/2025advanced.onlinelibrary.wiley.com/doi/10.1002/... More scary* mRNA delivery advances. *exciting.advanced.onlinelibrary.wiley.comA Serum Resistant Polymer with Exceptional Endosomal Escape and mRNA Delivery Efficacy for CRISPR Gene TherapyA fluoropolymer, FD17, identified in a polymer library, exhibits exceptional serum stability and endosomal escape, enabling efficient mRNA delivery. FD17 facilitates the intracellular delivery of mRN... 000
Reposted by Tony McChrystalTom Gauld @tomgauld.bsky.social · 10/02/2025My latest cartoon for @newscientist.com 4159281960
Reposted by Tony McChrystalJohn Topham @johntopham.bsky.social · 10/02/2025This could help a lot of people if it works out medicalxpress.com/news/2025-02...medicalxpress.comResearchers discover a major driver of inflammatory pathology in autoimmune and chronic inflammatory diseasesOur immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system—a group of proteins that pat... 042
Reposted by Tony McChrystalLuciano A. Masullo @lumasullo.bsky.social · 10/02/2025ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1... 15315101
Reposted by Tony McChrystalAngie Rasmussen @angierasmussen.bsky.social · 09/02/2025Editing scientific content for political purity is turning MMWR into a compromised propaganda organ. And why are the propaganda squads at CDC replacing specifically H5N1 bird flu studies? I’ve got some pretty serious fascism- and flu-related concerns about this. 8351151
Reposted by Tony McChrystalAndrea Luck @andrealuck.bsky.social · 09/02/2025Cool image of clouds over the Northern Hemisphere of Mars taken by CNSA's Tianwen 1 Full size & more info: flic.kr/p/2qKEu4g Image Processing: Andrea Luck Raw Image: CNSA/CLEP/PEC/MoRIC 2024-01-27 at 3230 km From the left: Milankovic Crater, Alba Mons and Tempe Terra North is up 525339
Reposted by Tony McChrystalPearl Freier @pearlf.bsky.social · 08/02/2025If you have encountered pediatric interdigitating dendritic cell sarcoma (IDCS), indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases—please see short thread below & reach out to Sri Kosuri: #sarcoma #medsky #biosky 063
Tony McChrystal @tonymac5.bsky.social · 08/02/2025Honestly, if this keeps going, it will be the single biggest, stupidest, most damaging self-inflicted wound any country has ever inflicted on itself. 010
Reposted by Tony McChrystalEast Anglia Bylines @eastangliabylines.co.uk · 08/02/2025Homelessness. 160,000 children in temporary accommodation. Lack of permanent home contributing factor in death of 74 (if not many more) kids since 2019. 39,000 families & pensioners placed out of borough. All @privateeyenews.bsky.social figures. The St Albans exhibition is a timely reminder...eastangliabylines.co.ukOutsiders exposed: powerful photos reveal the ruthless reality of homelessnessA striking exhibition in St Albans reveals the harsh realities of homelessness through powerful black-and-white photography 37930
Reposted by Tony McChrystalDavenant 📸 @marcdavenant.bsky.social · 08/02/2025Loise from the Outsiders project. She spent fours years sleeping rough in London with her baby, afraid of trying to get support due to the hostile environment. They lived on scraps of discarded food from bins, or which had been dropped on the ground. 26925
Tony McChrystal @tonymac5.bsky.social · 08/02/2025Went to see Companion earlier this week. Good thriller, some heavy sci-fi themes handled adeptly, with black humour and excellent action. Sophie Thatcher was amazing. 110
Reposted by Tony McChrystalThe Dread Duck Pirate Mark Brooks @markbrooksart.bsky.social · 08/02/2025Well shit. 11746231
Reposted by Tony McChrystalSTITCHES Medicine - the Best of Medical Research @medicine.stitches.today · 08/02/2025A novel CAR T-cell therapy achieved an 82% response rate in lymphoma patients, demonstrating efficacy even at low doses. by Park JH, Palomba ML (...) Sadelain M et 31 al. in J Clin Oncol #MedSky 📖 read the article: ascopubs.org/doi/10.1200/JCO-24-024… 0195
Reposted by Tony McChrystalLouise Matsakis @lmatsakis.bsky.social · 07/02/2025SCOOP: FBI director nominee Kash Patel disclosed he received up to $5M in shares of a mysterious entity in the Cayman Islands called Elite Depot. Elite Depot is a parent organization of fast-fashion giant Shein, according to corporate records I reviewed www.wired.com/story/kash-p...wired.comTrump's FBI Pick Kash Patel Took Up to $5M in Stock from Chinese Ecommerce Giant SheinDonald Trump’s pick for FBI director told senators he has no plans to divest his shares, which his financial disclosure form says were received in exchange for consulting services. 16229331361
Reposted by Tony McChrystalLeo Lam, Ph.D.💉⚕️🌎 @drleolam.bsky.social · 08/02/2025The N.I.H. will cut about $4 Billion from federal research grants that support cancer, virus and heart disease research. This is a direct attack on science, and America's leadership in medical innovation. This is the kind of "winning" they want? Seriously? 4268
Reposted by Tony McChrystalWIRED @wired.com · 07/02/2025SCOOP: A US Treasury threat intelligence analysis has designated DOGE staff an ‘insider threat'. An internal email reviewed by WIRED calls DOGE staff's access to federal payments systems “the single biggest insider threat risk the Bureau of the Fiscal Service has ever faced.”wrd.cmA US Treasury Threat Intelligence Analysis Designates DOGE Staff as ‘Insider Threat’An internal email reviewed by WIRED calls DOGE staff's access to federal payments systems “the single biggest insider threat risk the Bureau of the Fiscal Service has ever faced.” 6932685911460
Reposted by Tony McChrystal𝚜𝚝𝚎𝚙𝚑𝚊𝚗𝚒𝚎✩ @allmylovesteph.bsky.social · 08/02/2025BREAKING: A federal judge has blocked Elon Musk’s DOGE from accessing sensitive US Treasury Department material. He set a hearing for February 14th.apnews.comFederal judge blocks Elon Musk's DOGE from accessing sensitive US Treasury Department materialThose records contain personal data such as Social Security and bank account numbers for millions of Americans. 1228
Tony McChrystal @tonymac5.bsky.social · 08/02/2025advanced.onlinelibrary.wiley.com/doi/10.1002/... This is fascinating research. Probably a long time till any treatment is possible, but reverting cancerous cells to healthy cells would be amazing.advanced.onlinelibrary.wiley.comAttractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal TumorigenesisREVERT (REVERse Transition) is presented, a systems framework developed to identify a reversion switch in the transition process of tumorigenesis through comprehensive attractor landscape analysis of... 010
Reposted by Tony McChrystalCorey S. Powell @coreyspowell.bsky.social · 28/01/2025You've probably heard that "we are stardust," but this graphic breaks it down and tells you what kind of stars your dust came from--and which elements didn't come from stars at all. 🧪 svs.gsfc.nasa.gov/13873/ 18444160
Reposted by Tony McChrystalCharlie Warzel @cwarzel.bsky.social · 07/02/2025New: We spoke to government IT employees/contractors about DOGE. Their warnings were dire. The people who maintain the systems that keep the country working are terrified. "This is the largest data breach and the largest IT security breach in our country’s history—at least that’s publicly known."theatlantic.comThe Government’s Computing Experts Say They Are TerrifiedFour IT professionals lay out just how destructive Elon Musk’s incursion into the U.S. government could be. 14465713215
Tony McChrystal @tonymac5.bsky.social · 07/02/2025Actions are going to meet consequences. Unfortunately, with infectious diseases and anti-vaxxers, it's usually the most vulnerable who face those consequences. 000
Reposted by Tony McChrystalNeuroJoe @neurojoe.bsky.social · 06/02/2025My wife is an NIH funded scientist primary investigator on the CRISPR For Cure HIV program. The goal is to use gene editing to inactivate HIV and produce a functional AIDS cure. She was ordered by an NIH program officer to take down the website last week. Their future funding is in dire straits. 34722
Tony McChrystal @tonymac5.bsky.social · 06/02/2025I know it can a teensy bit annoying for power mad autocrats and democratic governments alike, but the rule of law is there for a reason. Hopefully, America will find out sooner rather than later. 010
Tony McChrystal @tonymac5.bsky.social · 05/02/2025It's okay, they'll just stop funding the testing and proclaim that the outbreak is over. DOGE for the win! 🤪media.tenor.coma cartoon character sitting on a couch with the words im totally not crazy you can trust meALT: a cartoon character sitting on a couch with the words im totally not crazy you can trust me 010
Reposted by Tony McChrystalEmily Mullin @emilymullin.bsky.social · 05/02/2025Hi all, I'm a WIRED journalist on the science desk. If you're a government scientist or federally funded researcher with info to share about the Trump transition, please feel free to contact me securely on Signal: emullin.06 4035071592
Tony McChrystal @tonymac5.bsky.social · 05/02/2025www.science.org/doi/10.1126/...science.orgStem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expressionID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer. 010
Reposted by Tony McChrystalKristian G. Andersen @kgandersen.bsky.social · 05/02/2025Genotype D1.1 of H5N1 confirmed in Nevada cattle, which is the one circulating in birds and not B3.13, causing the wider cattle epizootic in the U.S. In other words, this is a second observed jump from birds into cows. Keep rolling the dice, shall we? www.feedstuffs.com/agribusiness...feedstuffs.comNew HPAI genotype found in Nevada dairy cowsAPHIS confirms first detection of D1.1 genotype in dairy cattle through NMTS testing. 421499
Tony McChrystal @tonymac5.bsky.social · 05/02/2025medicalxpress.com/news/2025-02... Potentially great news, positive results from a phase 1 trial of personalised cancer vaccines post-surgery.medicalxpress.comCancer vaccine shows promise for patients with stage III and IV kidney cancerDana-Farber Cancer Institute researchers report that all nine patients in a clinical trial being treated for stage III or IV clear cell renal cell carcinoma (a form of kidney cancer), generated a succ... 041
Tony McChrystal @tonymac5.bsky.social · 05/02/2025phys.org/news/2025-02...phys.orgActive agent against cancer metastasis discovered: Adhibin prevents migration and attachment to other cellsEvery cell in the body normally has its fixed place as part of a tissue structure. Except for a few cell types, such as blood or immune cells. But cancer cells also cross established boundaries, grow ... 000
Tony McChrystal @tonymac5.bsky.social · 05/02/2025Not sure of the choice for the big enemy in the new Fantastic Four film. 010
Reposted by Tony McChrystalspaminthelab.bsky.social @spaminthelab.bsky.social · 04/02/2025Due to the freeze on credit card use, my laboratory (in the FDA) risks losing the contents of our liquid nitrogen tanks which store INVALUABLE samples-they cannot be replaced, so they are literally priceless, and reflect about 50 years worth of research. 9931991704
Reposted by Tony McChrystal🗽LOLGOP🗽 @lolgop.bsky.social · 04/02/2025"I just want to be clear about what's going on here." - @warren.senate.gov www.youtube.com/watch?v=RIHN... 20878583415
Reposted by Tony McChrystalJessica Elgot @jessicaelgot.bsky.social · 04/02/2025Kyrke-Smith says perinatal mental health care in England is ‘postcode lottery’, with disadvantaged women more likely to miss out www.theguardian.com/society/2025...theguardian.comLabour MP to push for better maternal mental health care after friend’s suicideLaura Kyrke-Smith says perinatal mental health care in England is ‘postcode lottery’, with disadvantaged women more likely to miss out 1257
Tony McChrystal @tonymac5.bsky.social · 04/02/2025medicalxpress.com/news/2025-02...medicalxpress.comResearch discovery halts childhood brain tumor before it formsScientists at The Hospital for Sick Children (SickKids) have discovered a way to stop tumor growth before it starts for a subtype of medulloblastoma, the most common childhood malignant brain cancer. 010
Tony McChrystal @tonymac5.bsky.social · 04/02/2025I wish Labour would pull their finger out. Still falling in to the old traps of timidity because they're too scared of Reform and Brexit. Get a closer relationship with the EU, get the economic benefits and shut Farage and Co up. They've got four years till they have to worry about elections. 040
Tony McChrystal @tonymac5.bsky.social · 04/02/2025medicalxpress.com/news/2025-02...medicalxpress.comPotential new therapy for childhood brain cancer could heal treatment-resistant tumorsBrain cancer is the second-leading cause of death in children in the developed world. For the children who survive, standard treatments have long-term impacts on their development and quality of life,... 000
Tony McChrystal @tonymac5.bsky.social · 04/02/2025The consequences of this insane appointment are on the quislings who voted to advance this grifting, demented huckster. 000
Reposted by Tony McChrystalMarvin Tanenbaum @marvintanenbaum.bsky.social · 03/02/2025Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation www.cell.com/cell/fulltex...cell.comLong-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translationRibosomes cooperate through transient collisions to ensure efficient translation. 411648
Tony McChrystal @tonymac5.bsky.social · 03/02/2025I feel that the 'This is fine' meme is getting a good workout today, thanks to events over the Atlantic. 010
Tony McChrystal @tonymac5.bsky.social · 02/02/2025One can only assume at this point that the USA has voted for the worst possible people to ever be in charge of the USA. 031
Tony McChrystal @tonymac5.bsky.social · 02/02/2025Humanity keeps inventing many wonderful, brilliant things. And then, straight away, humanity keeps kicking those things in the bollocks and making things worse for other bits of humanity. 010
Reposted by Tony McChrystalAlt National Park Service @altnps.bsky.social · 02/02/2025Please share: We’ve received word that Elon Musk’s staffers are using space characters to identify information leakers. Before sharing any information, please use a checker to detect and remove these. 196126504371
Tony McChrystal @tonymac5.bsky.social · 02/02/2025Installed DeepSeek on a whim, then asked it about Tianemen Square, then uninstalled it fairly quickly. May give OpenAI mini a shot. 000