Genomewide association studies (GWAS) of brain scans are complicated by the large number and high collinearity of the available image-derived phenotypes (IDPs). Here, we present DIMPLE-GWAS (Dimension...

Genomewide association studies (GWAS) of brain scans are complicated by the large number and high collinearity of the available image-derived phenotypes (IDPs). Here, we present DIMPLE-GWAS (Dimension...

Evidence from both GWAS and clinical observation has suggested that certain psychiatric, metabolic, and autoimmune diseases are heterogeneous, comprising multiple subtypes with distinct genomic etiolo...

Advances in genetic testing and artificial intelligence are changing what’s possible for those undergoing I.V.F. Are we ready for the future of fertility?

This mendelian randomization study identifies circulating proteins associated with risk for schizophrenia, bipolar disorder, major depressive disorder, and cognitive task performance.

ALT: a man in a sweater is standing in front of a door with christmas wreaths on it .

Private enterprises offer preimplantation genetic testing with polygenic scores to select embryos with ‘desirable’ potential. In silico simulations using biobank resources show that the selected embry...

This study aims to characterize the individual-level agreement of polygenic risk scores for coronary heart disease that perform similarly at the population level.

In 2023, the US Food and Drug Administration approved the first genetic test for predicting risk of developing a susbstance use disorder.1 The test, which is based on a set of 15 genetic variants, was...