iiinova — where your digital self keeps evolving

Spelling is important. A "vicious circle" is very different from a "viscous circle".

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David W (aka Flex NP) @rnflex.bsky.social · 5h

Full Retatrutide phase 3 obesity data published today. It's gonna take a minute to fill dissect this. The appendix alone has 70 pages of data. Long story short we created a drug that's almost too good. Huge chunks of people stopped or reduced doses from excess weight reductions.

nejm.org

Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity | NEJM

Retatrutide is a triple-receptor agonist of glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, and glucagon receptors. In this phase 3, randomized, double-blind trial, we assign...

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Derek Lowe @dereklowe.bsky.social · 10h

The craziest compound-impurity story I’ve ever heard:

science.org

Now That's An Impurity Story

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T. Greg Doucette @gregdoucette.bsky.social · 29/09/2026

"A county jury found Powell guilty on nine counts of election fraud last week, including lying about her residence, unlawfully registering to vote and fraudulently voting." www.sfgate.com/politics/art...

sfgate.com

MAGA candidate in small Calif. town convicted on 9 counts of election fraud

It turns out this conservative candidate wasn't following election laws herself.

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T-Kay @ttothekay.bsky.social · 20/09/2026

After being told a previous sketch with the words "Fuck ICE" was "needlessly hateful". So I felt I should make an apology. Sorry the message wasn't loud enough, clear enough, and didn't include Fuck the Pedo-in-Chief and all his fascist followers. It's not needless hate. It's positive intolerance.

A drawing of Cinn wearing an Elbows Up tanktop, giving double middle fingers, with the words "F*ck ICE, F*ck Trump, & F*ck the losers who support 'em" framing her.

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Todd Knarr @tknarr.bsky.social · 26/09/2026

So, in the Missouri election map dispute, the Supreme Court overturned the 8th Circuit ruling and required that the state use the 2022 map instead of the GOP's preferred 2025 map. There were no dissents, so not even Alito and Kavanaugh could find a way around the logic. apnews.com/article/supr...

apnews.com

Supreme Court rejects a Trump-backed Missouri congressional map for the third time

The Supreme Court has turned away an attempt to use a new Missouri congressional map backed by President Donald Trump.

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FINAL FANTASY XIV @en.finalfantasyxiv.com · 25/09/2026

Trail to the Heavens: FFXIV Original Soundtrack is available for digital download! 📲 sqex.lnk.to/HATWq0 The Blue-ray disc is also available for pre-order featuring songs across Patch 7.1 to 7.5, PLUS an adorable Musical 'Paca in-game minion code! 🦙 sqex.to/0sZCG

The album cover for the Trail to the Heavens: Final Fantasy 14 Original Soundtrack. It features a black and orange illustration of the Warrior of Light as a viper, looking up towards the viewer as he raises his swords in a battle-ready stance.

A render of the Musical 'Paca minion from Final Fantasy 14. A brown fluffy alpaca stands on a white background.

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Brian Smith @briansmith-photos.eurosky.social · 24/09/2026

One for the alt theme for #BirdoftheDay, and #BirdStare, and the Least Bittern from the Las Gallinas trip the other day - giving me a look, but hanging around and carrying on fishing. #Birds #eck 🪶

A frontal view of a Least Bittern (Botaurus exilis) (Ixobrychus exilis) perched on vertical green reeds at the water's edge. The small heron is looking directly at the camera, its brown and white streaked plumage providing camouflage against the dense vegetation. Its long legs and large feet are visible gripping the stalks above the green, reflective water. The setting is a marshy wetland in Marin County, California.

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Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 24/09/2026

Incredible. First Secretary Mullin claimed that DHS had identified 15,903 noncitizens on Nevada’s voter roll. Then DHS officials told a skeptical Nevada, no no no, that’s just people we flagged. Here are the names of 185 people we KNOW aren’t citizens. All 185 were citizens. DHS got 100% wrong.

When the Department of Homeland Security sent Nevada a list of 185 names last month that it claimed identified noncitizens who had been improperly allowed to register to vote, state election officials got to work.
On Tuesday, the state sent a strongly worded rebuke to the federal government: Every single person on the list was a lawful citizen.
"As for the 185 individuals, our records indicate that they were citizens," Greg D. Ott, a deputy attorney general in Nevada, wrote, according to a copy of a letter sent to Department of Homeland Security officials obtained through open records requests.
"You have provided nothing of substance to suggest otherwise."

Following the meeting, Ms. Vogt sent a clarifying email to Nevada officials. "I also wanted to be sure I clarified that we did not reduce the 15,903 to 185," she wrote. "We've manually reviewed some of the 15,903 and confirmed 185 are not U.S. Citizens."
Now, Nevada officials are saying even that 185 number is wrong. They also took issue with a letter D.H.S. sent them in early September, in which the agency reiterated its initial claims about nearly 16,000 noncitizens on the rolls and pressured state officials to review each case in a letter to Nevada officials in early September.

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Mark Hamill @markhamillofficial.bsky.social · 23/09/2026

This show is easily among the happiest (& zaniest) experiences I've ever had doing voiceover. Great scripts. Great cast. Great FUN! Now: Let's... Get... DANGEROUS!!! #DarkwingDuck #DisneyPlus

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Courtney Milan @courtneymilan.com · 22/09/2026

Anyway Judge McMahon's answer is "well if there's a problem, you fucking call me and give your shitty frivolous opinion to my face right then and there."

ORDER CONCERNING FREEMAN'S DEPOSITION
McMahon, J.:
My order requires no clarification. It is perfectly clear. Counsel for Ms. Freeman do not
get to set the rules.
Ms. Freeman will answer EVERY question that is put to her - whether or not the question
was asked previously.
If Ms. Freeman asserts attorney client privilege with respect to a question that was not
previously asked, you are to call my chambers immediately to obtain a ruling. If I have to rule on more than one frivolous attorney client privilege objection, there will be consequences, in the form of sanctions, adverse inferences, referrals to the court's Grievance
Committee with the possible revocation of pro hac vice admission to practice or admission to the Bar of this Court, and the possibility of a civil contempt holding. Please understand — this is not an idle threat. I am tired of this. I do not believe that Ms. Freeman's counsel is acting in good faith and I will not stand for being jerked around - and I am indeed being jerked around — in this
manner by any lawyer who practices before me.

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DiscussingFilm @discussingfilm.net · 21/09/2026

Callina Liang as Chun-Li on set of the ‘STREET FIGHTER’ movie.

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Todd Knarr @tknarr.bsky.social · 22/09/2026

So now we have dengue fever in Florida. Between diseases and an ego-maniac dictator wanna-be running things, real third-world vibes these days.

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Yamino @yamino.bsky.social · 20/09/2026

Look at them!!!

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Todd Knarr @tknarr.bsky.social · 18/09/2026

All licensed professions. They should be like law firms: the owners should have to be licensed to practice in the field the firm offers services in.

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Todd Knarr @tknarr.bsky.social · 14/09/2026

This is why the first thing I do with digital content is strip DRM from it and store a copy where the publisher can't access it. Digital content should work like physical: you may need to subscribe to get new issues, but once you get them they're yours.

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Todd Knarr @tknarr.bsky.social · 14/09/2026

My question would be how did this develop so quickly? It's not like this could've gone unnoticed for years...

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T. Greg Doucette @gregdoucette.bsky.social · 13/09/2026

Living adjacent to some of those communities, it's less the pay and more the lack of stuff (restaurants, entertainment, etc) Former client offers nearly 2x market rate as a baseline and still struggles to find people even willing to consider interviewing for openings. Last role was open for a year

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Todd Knarr @tknarr.bsky.social · 11/09/2026

Bonus points if you can identify the speed by the sounds of the connection handshake.

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Todd Knarr @tknarr.bsky.social · 10/09/2026

All phones are foldable. Once.

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Phil Foglio @thephilfoglio.bsky.social · 09/09/2026

#webcomics #girlgenius Girl Genius for 9/9 (www.girlgeniusonline.com/comic.php) Kaja says that she will be streaming tonight (www.twitch.tv/professoress...) at 6 PM PST, and she's bought new cookies and everything. Release the Hounds of Jollity!

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Todd Knarr @tknarr.bsky.social · 09/09/2026

We seem to be on the border between "days since last food-product recall due to contamination/disease/etc." and "food-product recalls so far today".

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Lar deSouza @lartist.bsky.social · 09/09/2026

New Pin Up for Star Trek Day! Lt M'ress from the Mirror Universe. Enjoy :)

cartoon: M'ress from ST TAS but dressed in a Mirror Universe uniform

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Todd Knarr @tknarr.bsky.social · 08/09/2026

After reading this entry from @dereklowe.bsky.social I wonder: given the sheer number of positive off-target effects of GLP-1s, are we looking at something that addresses a systemic deficiency in our diet or something similar? Because it's sure looking like it. www.science.org/content/blog...

science.org

GLP-1 Drugs for Aging?

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Kingfisher & Wombat @tkingfisher.com · 06/09/2026

Weird Sticks are hung! You’re getting an angled shot because I’ll probably spend the next week making small position adjustments since at least one is crooked but I’m not fixing it tonight. The only problem is that making these is kinda fun, so now I need another space that needs something.

A wall of six foot black and turquoise boards, accented in various colors with things glued to them at random.

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Kingfisher & Wombat @tkingfisher.com · 03/09/2026

Ecological destruction now recognized as sins against creation and the Creator? Fuck yeah, hook that shit to my badly lapsed veins!

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Matt Novak @paleofuture.bsky.social · 01/09/2026

This is pretty fucking wild. I had assumed in a worst case scenario he would target blue zip codes and toss ballots based on technicalities but this is even worse than I imagined.

Not only is this system astonishingly untested, USPS has simultaneously implemented an
impracticable zero percent failure rate.
13 When ballots are submitted to USPS in large-volume
batches, if any one ballot in the batch cannot be verified against the Portal, all ballots in that
batch will be rejected. For example, if a state election official brings a batch of 10,000 ballots to
USPS and USPS is unable to match just one of those ballots against the Portal – because, for
example, someone has recently changed their name after marriage or they’ve moved – then
USPS would refuse to mail the remaining 9,999 ballots as well. As the whistleblower notes,

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Todd Knarr @tknarr.bsky.social · 26/08/2026

Why the hell can't the people who design uniforms come up with something like this instead? They're supposed to be professionals and they're getting shown up by hobbyists.

Smart-looking uniform in dark blue and white.

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CK DexterHaven 🍂🍁🍂 @ckshowalter.bsky.social · 23/08/2026

So I freely confess I’m a dress uniform junkie. I’ve loved the Osprey books with the color panels that show off all the various fancy world uniforms. This uniform is a godawful nightmare and makes the Secret Service dress uniforms designed by Nixon look like runway level work

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Jjinandtonic @jjinandtonic.bsky.social · 22/08/2026

Discovering a new type of guy

asideoftrashplease
I was once talking to my 75 year old Chinese dad in passing about a trans friend of mine not getting along with her family and he asked why and I said err, because she's trans, dad.
He asked: "Oh, was she the only son or something before *waves hand*?" and I was like, warily, no she has two brothers. And he responded with a great deal of confusion: "Then what's their problem?!?!"
Later on: "Anyway, even if she WAS the only son, that's not her problem, that's THEIR problem.
They should have had more sons if they were going to be bothered about it."

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Micah @rincewind.run · 21/08/2026

Discworld QOTD, from Pyramids “Broadly, therefore, the three even now lurching across the deserted planks of the Brass Bridge were dead drunk assassins and the men behind them were bent on inserting the significant comma.”

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Micah @rincewind.run · 20/08/2026

I never thought we'd get to the point where I would be like "wow Trump having an affair with a 35 year old would be better than whatever the fuck this is" but here we are

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Kingfisher & Wombat @tkingfisher.com · 13/08/2026

I was literally JUST doing a talk about this with @mcmanlypants.bsky.social an hour ago! The thing is that the Rockies are so much bigger than you that they don’t notice if you exist. But the Appalachians are so much older than you that if they notice you, bad shit’s about to go down.

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Democrats @democrats.org · 12/08/2026

HUGE: Ilhan Omar has won the Democratic primary for Minnesota’s 5th Congressional District in her bid to serve a fifth term in the House. Congrats, Congresswoman!

A graphic featuring an image of Ilhan Omar standing in front of a waving American flag. Text on screen reads, "Ilhan for Congress." Below, a donkey and the outline of the state of Minnesota appear.

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Pre // Wari @wariwariway.bsky.social · 11/08/2026

Are we tired of Nophica yet? Naaaaah... I'm too proud lol. Glad to keep getting pictures from the FFXIV shoot at Otakon ~ #ffxiv #finalfantasyxiv #ff14 #nophica

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Dr Lindsey Fitzharris @drlindseyfitz.bsky.social · 09/11/2024

With science falling under increasing attack, this medical historian is here to remind people of the power of vaccines. THREAD👇 Hard-hitting polio advert from 1958. In the first half of the 20th century, polio was the leading cause of death in children and young adults. 1/7 #history #skystorians

An advertisement for the polio vaccine which reads: "they all got vaccine except dad...don't take a chance...take your polio shots!" It depicts a photo of a family gathered around a father who is in an iron lung.

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The Tennessee Holler @thetnholler.bsky.social · 10/08/2026

🔥 TEXAS: “Registered voters in Tarrant County has increased 30% — to be closing polling stations is blatant voter suppression… when I joined the Navy, I swore an oath to defend the Constitution from enemies foreign and domestic…Talking to you, Comrades."

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Inbal Breda @greyannis.bsky.social · 09/08/2026

Might as well post it here! A magical girl animation I've been slowly chipping at over the weekends for ages.

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aya 🐰 @itouyas.bsky.social · 08/08/2026

RELIC FINISHED WAHHHH SO CUTE I dyed it blue and white for snow!!!! Back to work hahaha

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Roarin' Falco @falco.works · 06/08/2026

The Day We Met: Chapter 5, Page 1

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