Human TOM complex was revealed as a dynamic hub, with FKBP8 as a human-specific interactor shaping biogenesis.

In BriefHere, we used an integrative approach to study key interactions of a spider-like complement inhibitor from human serum, C4b-binding protein (C4BP). We characterized interactions with complemen...

C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalent...