Reposted by peterslab (BIOCEV,CZ)
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in
@NatureComms
, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
rdcu.be
Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex
Nature Communications - This study shows how the NgBR subunit controls the activity of human cis-prenyltransferase, a key enzyme for protein glycosylation. Combined experimental and computational...
