iiinova — where your digital self keeps evolving

Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 10h

How long do you need to fast to increase autophagy? 24 hours? 48? 72? The human evidence cannot yet give us a reliable answer. Dr Sanjna Singh and I separate fact from fiction in our new open-access review: doi.org/10.1042/BST2... #fasting #autophagy

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 10h

Here is our new paper from Dr Sanjna Singh on dietary #protein and #autophagy measured in human blood. It was a negative result, but probably the hardest research I've been involved with. Proud of the study and wonderful collaborators! www.sciencedirect.com/science/arti... @sahmri.bsky.social

sciencedirect.com

Reduced dietary protein intake does not alter autophagy in human blood: A randomized crossover study in healthy adults

Autophagy activation is a promising strategy to counteract age-related cellular dysfunction. While preclinical studies suggest dietary protein restric…

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Reposted by Assoc. Professor Tim J Sargeant

The Journal of Physiology @jphysiol.bsky.social · 10/09/2025

Gabriela Geraldo Benzoni offers this #JournalClub article discussing time-restricted feeding and autophagic flux based on the recent work of Bensalem et al. (2025) ✍️ 🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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JCI insight @insight.jci.org · 07/09/2025

ICYMI: Autophagy is linked to health span and modified by nutrition. @timsargeant.bsky.social show a high-protein meal does not alter autophagic flux in human peripheral blood mononuclear cells within 1 hour—challenging the notion that fasting activates autophagy. buff.ly/aPrgr5F

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 25/08/2025

Check out our new paper! We tested whether a high protein milkshake would suppress #autophagy measured in human blood after 1 hour. Surprisingly we got a negative result, despite clear metabolic responses. @sahmri.bsky.social @jci-insight.bsky.social insight.jci.org/articles/vie...

insight.jci.org

JCI Insight - High protein does not change autophagy in human PBMCs after 1 hour

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 13/08/2025

Well worth a five minute read - Interventional study showing lifestyle interventions boost #cognition during #aging - the structured intervention group focused on #exercise, #diet advice, and cognitive exercises. Lifestyle is important for #brain aging! www.alzforum.org/news/confere...

alzforum.org

Lifestyle Makeover Boosts Cognition in Older Adults | ALZFORUM

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 12/06/2025

New research paper on human #autophagy from our group at @sahmri.bsky.social. Dr Linh Dang analysed autophagic flux with cell type specificity. We show data important for designing clinical trials for human autophagy - cell type matters: faseb.onlinelibrary.wiley.com/doi/10.1096/... #aging

faseb.onlinelibrary.wiley.com

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 04/06/2025

Sunrise from @sahmri.bsky.social with the Adelaide Oval and St Peter's Cathedral

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Reposted by Assoc. Professor Tim J Sargeant

SAHMRI @sahmri.bsky.social · 04/06/2025

A/Prof @timsargeant.bsky.social is the latest guest to feature on the Community Conversations podcast. 🎙️ A/Prof Sargeant discusses all things autophagy - the latest research, lifestyle interventions, tips for optimising cellular health and more! Listen 🎧 sahmri.au/CC-Tim-Sarge...

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Adlung Lab @adlunglab.com · 22/05/2025

🍽️ Can autophagy increase with age rather than decline? 🤔 What if the story we’ve been told about its decline is missing key details? ⤵️ #aging

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Thanh Nguyen @thanhrnguyen.bsky.social · 31/05/2025

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: www.isa11.org Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 30/05/2025

I'm looking forward to attending the 11th International Symposium on #Autophagy. The last one in Sapporo, Japan was a great meeting and that is set to continue in Lorne, Victoria, in November of this year. Early bird rego closes August 29 here: www.isa11.org #isa11

isa11.org

11th International Symposium on Autophagy

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Reposted by Assoc. Professor Tim J Sargeant

SAHMRI @sahmri.bsky.social · 09/05/2025

Over his career, Emeritus Professor John Hopwood AM set the bar for innovative research. Now, he and his wife Barbara provide philanthropic support, insisting their donations not be restricted to specific projects to create scientific freedom. Read 📖 sahmri.au/Cost-of-Rese...

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Reposted by Assoc. Professor Tim J Sargeant

The Journal of Physiology @jphysiol.bsky.social · 22/05/2025

Julien Bensalem et al. observed that intermittent time-restricted eating may increase #autophagic flux in humans 🍽️ 🔬 📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Reposted by Assoc. Professor Tim J Sargeant

Oregon 🕎🎲 @oregonthedm.bsky.social · 09/04/2025

Biggest commitment to a 3 second joke I've ever seen

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 08/04/2025

Check out our latest Comment in Nature Cell Biology on #autophagy (the mechanism that cells of your body use to recycle damaged material and slow ageing). While declining autophagy is often seen as a hallmark of #ageing, we explore emerging exceptions to this idea. www.nature.com/articles/s41...

nature.com

Autophagy does not always decline with ageing - Nature Cell Biology

Autophagy has long been presumed to decline with age, underpinning its designation as a hallmark of ageing. However, emerging evidence challenges this notion, showing tissue-specific variability and, ...

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Reposted by Assoc. Professor Tim J Sargeant

SAHMRI @sahmri.bsky.social · 03/04/2025

New research shows giving antibiotics to newborns can reduce their immune response to vaccines, likely due to changes in gut bacteria. 🦠 This research, led by Prof @davidjlynn.bsky.social, was featured in @nature.com, one of the world's most prestigious journals. 📰 sahmri.au/Newborn-Anti...

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 30/03/2025

Great commentary on 'lysohormesis', for all you longevity fans out there: "Just as physical exercise stresses the body to build stronger muscles, a controlled mild stress to lysosomes could boost resilience and improve health outcomes across the lifespan." www.nature.com/articles/s41...

nature.com

Harnessing lysohormesis for healthy ageing - Nature Cell Biology

Lysosomal dysfunction is emerging as a common pathogenic mechanism underlying normal ageing and many age-related diseases. Lysohormesis, the triggering of beneficial adaptations by mild lysosomal stre...

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 22/03/2025

Matt Kaeberlein giving his opinion on direct to consumer biological ageing tests and the ageing field in general. Definitely worth a watch. youtu.be/8mlRkXZFvi8?...

youtu.be

The Truth About Biological Age Tests

YouTube video by Dr Matt Kaeberlein

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 22/03/2025

Good news on the dementia front - incidence is dropping - "Scientists don’t know what may have had the biggest impact, but recent studies have emphasized the effects of modifiable factors such as exercise, smoking, hearing loss, and hypertension on dementia risk" www.alzforum.org/news/researc...

alzforum.org

Is Dementia Incidence Still Dropping? Birth Cohort Data Say Yes. | ALZFORUM

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Reposted by Assoc. Professor Tim J Sargeant

Korolchuk Lab @korolchuklab.bsky.social · 16/03/2025

#Autophagy and #mTOR papers from past two weeks, enjoy thanks to @biomednews.bsky.social search engine! biomed.news/bims-auttor/... biomed.news/bims-auttor/...

media.tenor.com

a man with a skeleton in the background is wearing a science shirt

ALT: a man with a skeleton in the background is wearing a science shirt

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SAHMRI @sahmri.bsky.social · 14/03/2025

Today, A/Prof @timsargeant.bsky.social accepted an incredibly generous donation following his gripping talk at the Sohn Hearts and Minds Conference last November. 👏 SAHMRI sends our most sincere thanks both to Sohn and the state government for the invaluable opportunity and support.

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SAHMRI @sahmri.bsky.social · 12/03/2025

The specialist team of radiochemists at SAHMRI, known as MITRU, have been featured by 7 NEWS Adelaide. 🎥 Each and every morning, they fire up SA's only cyclotron, producing radiopharmaceuticals that are essential to the state. More ➡️ sahmri.au/MITRU-Feature

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 04/03/2025

Cheers! I think the 16-24 h number came from mouse work. I, like you, suspect that this won't cut it in humans. We're trying to resolve the caveats at the moment, but we're also working on a protein that is behaving like an autophagy biomarker. That's where I see the future - autophagy biomarkers.

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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 27/02/2025

This is well worth a read - it covers different theories of why we #age and die, and uses interesting examples from the animal kingdom to support (or otherwise) different hypotheses #aging From pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov

PubMed

PubMed® comprises more than 37 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central a...

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