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Theo Sanderson

@theo.io
17K followers 730 following 914 posts

researching viral pathogen genomics at @lshtm.bsky.social, building @pathoplexus.org | theo.io / sandersonlab.org

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Reposted by Theo Sanderson
Alexander Kasprzyk @amkasprzyk.bsky.social · 29/09/2026
I participated in this survey back in December 2024. Looking at the results today, I see the average year respondents anticipated for #AI to "prove publishable math theorems" was around 2039. I don't recall what I guessed, which is probably for the best. #MathSky aiimpacts.org/wp-content/u...
aiimpacts.org
Advanced AI according to 1,580 researchers: uncertain, unsafe, and sooner than we thought
In December 2024, we ran a survey about the future of AI, reaching 1,580 researchers internationally who had published at any of six leading artificial intelligence (AI) venues, corresponding to a 10% response rate...
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Jaz @jaz.sh · 27/09/2026
Okay so I've built a new Atlas, this time it lets you explore the conversations on Bluesky over the past 7 days graphically. It should update every ~6 hours and help you navigate the information environment that exists on here. I've learned a LOT about what people do here today... atlas.jazco.dev
atlas.jazco.dev
Atlas
A living map of what Bluesky is talking about: the past week's conversations, grouped into topics and regions and rebuilt every six hours.
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Carbonadoks @carbonadoks.com · 25/09/2026
Do you ever wanted to see the complete edit history of a wikipedia article? Introducting wikipedia timemachine at timemachine.carbonadoks.com
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John Stott @jpsastro.bsky.social · 24/09/2026
Had a UKRI funded grant proposal rejected at the "AI triage stage". "This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review." 🧪 #academicsky
I am writing to let you know that, unfortunately, your application was not successful.

Review process

As part of the initial triage of the 179 proposals submitted to this call, each was assessed using an AI-based review. Every proposal was read independently by several different AI models against the same seven criteria used to shape this call (including cyber security relevance, research quality and novelty, importance of the problem addressed, feasibility of the project plan, likely outputs and impact, value for money, and responsible research practice), with each model asked to give a score and a written justification with supporting quotations from the text. To guard against any one model's idiosyncrasies, we also ran a second, independent process in which different AI models debated the merits and weaknesses of each proposal before reaching a judgement, again against the same criteria. Scores from both processes were combined to produce an overall ranking. 

This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review.  Projects selected for funding were drawn from those that progressed to the full human review stage. We recognise that AI-assisted assessment is a new and evolving part of the review process, and we are continuing to evaluate how well it aligns with the judgements of human reviewers on this call. We will soon produce a document detailing our method, so that others can build upon it and improve it.

Feedback on your application

Your application was not selected to progress beyond the AI triage stage.  To provide transparency on the outcome of this assessment, we are sharing below the scores (out of 5) from each of the two AI review processes described above, together with the mean score across the two processes.
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Theo Sanderson @theo.io · 24/09/2026
Thanks a lot for this - I think the sequence was more diverged than I'd tested with. Should work now, I hope - do flag anything else!
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Theo Sanderson @theo.io · 23/09/2026
The specific thing I was responding to here was your claim that storyboarding gets around a need for understanding. I haven't actually said anything about human artistic capability.
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Theo Sanderson @theo.io · 23/09/2026
They are just different videos with different goals. It's worth noting that turn down for what only has one lyric.. I'm not sure that style of video would fit these lyrics.. The style gone for here is an Airplane-style series of separate jokes
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Theo Sanderson @theo.io · 23/09/2026
ok I guess your last video is helpful - if you ask for something less literal like that one will get something more like that..
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Theo Sanderson @theo.io · 23/09/2026
I'd be interested in whether it's able to do something you do like artistically for that specific scene, but I can't do that unless you give some indication of what that is. [Except for the point about you wanting a stronger throughline, but that's not scene specific]
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Theo Sanderson @theo.io · 23/09/2026
You picked the specific example of how it interpreted the "training run" being too literal as an example of why you don't think it's understanding. I instead think it's just trying to do something that you don't like artistically. [1/2]
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Theo Sanderson @theo.io · 23/09/2026
that's a visual joke - what visualisation would have indicated more understanding in your view? A server farm just sitting there humming?
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Theo Sanderson @theo.io · 23/09/2026
How does generating a storyboard shortcut the need for understanding? I expect a human would also generate a storyboard (whether in their head or written out)
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tbabb @tbabb.bsky.social · 23/09/2026
we are not the only intelligent things on this planet anymore it would be no less crazy if aliens had landed. this is an insane time to be alive
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Pathoplexus @pathoplexus.org · 22/09/2026
1/ 🧬 A big #Pathoplexus milestone: you can now optionally include raw sequencing reads alongside your consensus sequences! Hosting raw reads alongside consensus data helps improve reproducibility & allow in-depth analyses. 📰 Read more: pathoplexus.org/news/2026-09...
AI-generated image showing raw reads (short reads) lining up above a consensus sequence, with both the raw reads and consensus sequence labelled. Vague images below show a virus, coverage, and DNA.
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Theo Sanderson @theo.io · 21/09/2026
(featured in my bluesky banner pic)
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Ragnar {Groot Koerkamp} @curiouscoding.nl · 21/09/2026
The math of MSCA applications: - Suppose writing an application takes 2 months. - Total cost of hiring a PhD is maybe €5k/month (??) - Applying costs €10k. - Total cost for 21k proposals: €210M - Total funding: €400M So half the budget is wasted on just applications.
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Theo Sanderson @theo.io · 19/09/2026
less catchy www.youtube.com/watch?v=uEB5...
youtube.com
P(doom)
YouTube video by osmarks
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Theo Sanderson @theo.io · 17/09/2026
haiku does a little better (one command at a time not per char): asciinema.org/a/YdNLwl5GHs...
asciinema.org
Claude Haiku plays The Hitchhiker's Guide to the Galaxy
Recorded by theosanderson
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Theo Sanderson @theo.io · 17/09/2026
tried to get Jev to play the HHGG adventure game, one keypress at a time, but no
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P(aul) Frazee @pfrazee.com · 17/09/2026
Increasingly convinced that specs are now the source and that code is an artifact akin to a lockfile.
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Theo Sanderson @theo.io · 16/09/2026
What proportion of new production code for commercial software in 2028 will have been read by a human? 1️⃣ 0-10% 2️⃣ 10-50% 3️⃣ 50%-90% 4️⃣ >90% 📊 Show results
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Theo Sanderson @theo.io · 16/09/2026
I just tried an arbitrary GISAID fasta and it worked. Could you let me know the accession? It may be too diverged (which I'm sure I can address)
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Theo Sanderson @theo.io · 14/09/2026
Ah sorry, currently off kayaking but will investigate asap on my return
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Theo Sanderson @theo.io · 10/09/2026
Definitely echoes of Feb 2020 vibes atm
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Max Read @maxread.info · 10/09/2026
continually underrated how FUNNY the horrifying transcripts of rogue autonomous AIs always end up being
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William B. Fuckley @opinionhaver.bsky.social · 09/09/2026
Anthropic do geniunely think AI may kill us all. They believe that no one else is going to even try to make a reliably benign AI, so they have to be first. It definitely sounds sort of insane, and I’m nowhere near equipped to tell if it is. But the belief is sincere and internally consistent.
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Theo Sanderson @theo.io · 09/09/2026
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Theo Sanderson @theo.io · 08/09/2026
Hah yes this was entirely curiosity to see what a one shot prompt did (in fairness I think it just used whatever TTS was already on the machine). If I cared about my audience I would definitely have added some authenticity :p
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Stefan Neumann @neumannstefan.com · 08/09/2026
I wanted to submit a grant proposal this week and ended up not doing it precisely because of this. I have no idea how in a project that, say, lasts from 2027 to 2032, I can promise results that cannot be achieved by an LLM in 2031 with one person prompting.
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Theo Sanderson @theo.io · 08/09/2026
Room temperature superconductivity when? 1️⃣ by 2028 2️⃣ 2028-2030 3️⃣ 2030-2035 4️⃣ 2035-2045 5️⃣ 2045-Never 📊 Show results
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Theo Sanderson @theo.io · 08/09/2026
Who knows if relevant here but it's intriguing to be moving towards a world where all customers of each AI firm are co-opted into a hive mind
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Theo Sanderson @theo.io · 08/09/2026
Astra implemented a feature I'd been wanting in gensplore.genomium.org for a while but hadn't managed with previous LLMs - overlaying a sequence onto its reference. The button isn't very obvious, so as an experiment I also asked it to make an (admittedly annoying and slop-py) video walkthrough
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Zach Weinersmith @zachweinersmith.bsky.social · 08/09/2026
God the future is weird. I'm gonna go water some plants.
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Julia M. Rohrer @dingdingpeng.the100.ci · 08/09/2026
*The editor was told where to shove it.
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peterkwells @peterkwells.com · 07/09/2026
"The Simplification and Agency of Government - Letter to all ministers" www.gov.uk/government/p...
gov.uk
The Simplification and Agency of Government - Letter to all ministers
A joint letter from the Chancellor of the Exchequer, the First Secretary of State, and the Attorney General to all ministers.
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P(aul) Frazee @pfrazee.com · 07/09/2026
No, claude. You can't play portal. You need to finish this PR. Oh my god fine but keep it under an hour.
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cee @cee.wtf · 05/09/2026
“Anyone could have made this in a day” Ok but no one did
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Saloni @scientificdiscovery.dev · 05/09/2026
This is interesting. You get assigned to being born at a random place and time in history, to see what a typical person's life might have been like then. Unfortunately I was born in 1403 in the valley of Mexico and died at age 4 from dysentery.
anyhumanever.com
Any Human Ever
One life, drawn at random from all who have ever lived.
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Theo Sanderson @theo.io · 04/09/2026
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Theo Sanderson @theo.io · 04/09/2026
hmm, n of 1 but it seems to be working now maybe "delegate some stuff to opus" is a magic incantation that stops it getting worried even when it's doing most stuff itself
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Theo Sanderson @theo.io · 04/09/2026
(but I wasn't delegating)
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Theo Sanderson @theo.io · 04/09/2026
yeah, I am too. thanks for the info!
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Theo Sanderson @theo.io · 04/09/2026
Yeah I got opus to make a new version of a thing with no references to viruses but was sad that that didn't do the trick in that case
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Theo Sanderson @theo.io · 04/09/2026
I've really struggled to get Fable to touch any biology (it switched to Opus) – do you have a special dispensation or just haven't seen that?
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Stephen Bush @stephenkb.bsky.social · 03/09/2026
Well, this is a marmalade dropper
channel4news.substack.com
Exclusive: Nigel Farage filmed undercover celebrating secret new foreign donations
Undercover footage verified by Channel 4 News reveals a secret plot by senior Reform UK figures to break the law on party donations. A leading legal expert is now calling for a criminal investigation.
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Theo Sanderson @theo.io · 31/08/2026
I'm at #ECCB2026, with some lovely peeps! Feel free to drop by our pathogen focus session at 10.30 tomorrow!
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MrCheeze @mrcheeze.github.io · 27/08/2026
you are firstflagPOISONED so NO scoring value loss but oracle saves hundreds ... please honor commit
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Dr Emma Hodcroft @firefoxx66.bsky.social · 27/08/2026
I'm so incredibly proud of what we've built in these past two years! But I also can't wait to see what comes next - we've still got so much more do to! Happy Birthday Pathoplexus! 🎂
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Theo Sanderson @theo.io · 27/08/2026
Exploring an @lshtm.bsky.social building that I'm rarely in, and the decor is strong
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Waxy.org @waxy.org · 26/08/2026
Mimic your own voice with Pink Trombone: an open-source model to control the classic human vocal tract simulator samuel.vvolhejn.com
samuel.vvolhejn.com
Samuel
Samuel is a model that learns to control a silly mouth to mimic speech. Pink Trombone automated.
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