iiinova — where your digital self keeps evolving

Reposted by Gogl lab

Ylva Ivarsson @ivarssonlab.bsky.social · 11/09/2026

Do you want to be my colleague? We are recruiting a tenured #Associate #Professor in #Biochemistry to the Department of Chemistry for Life Sciences at #Uppsala University. Deadline for application November 20. www.uu.se/en/about-uu/...

uu.se

Associate Professor in Biochemistry - Uppsala University

Associate Professor in Biochemistry, Department of Chemistry for life sciences, Uppsala University

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Gogl lab @teamgogl.bsky.social · 21/08/2026

SEP is the 3-letter code for phospho-Ser. I think Nature is hinting to us that it is modified at that position!

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Reposted by Gogl lab

Bogi @zbobo2.bsky.social · 28/07/2026

I am incredibly happy to share that my ANR JCJC project has been selected for funding! 🎉 I am deeply grateful to everyone who contributed to this proposal and supported me throughout the process. I can't wait to get started! #ANR #JCJC #Research #CNRS #Interactomics #TranscriptionFactors

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Gogl lab @teamgogl.bsky.social · 28/07/2026

Warm congratulations to Boglarka Zambo on her ACT-SYS project being selected for ANR funding! 🎉 #AAPG ACT-SYS will develop new systems biochemistry approaches for characterizing transcription factors. Looking forward to the exciting discoveries ahead!

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Reposted by Gogl lab

Ylva Ivarsson @ivarssonlab.bsky.social · 06/07/2026

Excited to share our preprint introducing ASHI: the Atlas of SLiM-mediated Human protein-protein Interactions. By screening 800+ domains against the human intrinsically disordered regions, we map 20,000 SLiM-mediated interactions. Many thanks to everyone involved! www.biorxiv.org/content/10.6...

biorxiv.org

An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions

Short linear motifs (SLiMs) within intrinsically disordered protein regions mediate transient interactions crucial for cell physiology. However, the global interaction landscape of human SLiMs remains...

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Gogl lab @teamgogl.bsky.social · 29/05/2026

Impressive! Are there/will there be some video tutorials somewhere?

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Gogl lab @teamgogl.bsky.social · 26/03/2026

Thank you for this nice summary! We also think that a major source of the inactive fraction is coming from nucleic acid content in the extract, however this is quite tricky to prove. Anyhow, this is not affecting the affinity so it is not causing a huge headache for most cases.

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Reposted by Gogl lab

Marcin J. Suskiewicz @msuskiewicz.eurosky.social · 25/03/2026

Just finished reading this lovely paper by @zbobo2.bsky.social , @teamgogl.bsky.social , Gilles Travé, and collaborators, describing a new technique for quantifying transcription factor:DNA binding without protein purification. A short reader's summary follows.

febs.onlinelibrary.wiley.com

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Gogl lab @teamgogl.bsky.social · 24/02/2026

I think they are pretty much invisible for standard proteomics because of their small size, but the most common should be HPV E6/E7 oncoproteins in HeLa cell lines.

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Gogl lab @teamgogl.bsky.social · 19/02/2026

These are also class 3 PDZ binding motifs.

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Reposted by Gogl lab

Varjosalo_Lab @varjosal.bsky.social · 15/12/2025

🧬 New paper in Nature Communications! We found that POLE2,part of DNA polymerase ε,moonlights as a receptor for NPF motifs, binding 70+ proteins across replication, transcription & repair. The interactome is more interconnected than thought. @teamgogl.bsky.social 🇫🇮🇫🇷🇭🇺🇬🇧 www.nature.com/articles/s41...

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Gogl lab @teamgogl.bsky.social · 15/12/2025

Fantastic collaboration led by co-first authors Salla Keskitalo and Boglárka Zámbó, with colleagues in Helsinki, Nice, Strasbourg, Budapest & London. First paper from our independent team supported by ATIP-Avenir, ANR & Fondation ARC

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Gogl lab @teamgogl.bsky.social · 15/12/2025

NPF motifs were thought to mainly bind EH domains. Instead, we uncover a highly degenerate and interconnected NPF-mediated network — suggesting similar hidden complexity may exist for other short linear motifs.

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Gogl lab @teamgogl.bsky.social · 15/12/2025

We show that the non-catalytic subunit of DNA polymerase ε binds NPF tripeptide motifs in many proteins. Beyond leading-strand DNA synthesis, this reveals unexpected interaction networks linked to replication and genome maintenance.

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Reposted by Gogl lab

CNRS Côte d'Azur @cnrscotedazur.bsky.social · 08/12/2025

👏 Félicitations à Gergő Gógl, chercheur @insermpacacorse.bsky.social à l'institut de Biologie Valrose, lauréat du programme Impulscience® de la Fondation Bettencourt Schueller. 👉 Découvrez les 7 scientifiques @cnrs.fr récompensés : www.cote-azur.cnrs.fr/fr/cnrsinfo/... @teamgogl.bsky.social

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Reposted by Gogl lab

Sophien Kamoun @kamounlab.bsky.social · 03/12/2025

I just published: ERC-Plus: jackpot science or missed chance to fix academia? My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building. medium.com/p/erc-plus-j...

medium.com

ERC-Plus: jackpot science or missed chance to fix academia?

My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re…

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Gogl lab @teamgogl.bsky.social · 04/12/2025

6000 expectedly unsupported application is wrong resource management. Counting with a 20 page application that is 120,000 pages of refined scientific text. I may be slow, but it takes me a day to refine a page. 120k page would take me 330 years of work. Every year. Plus the work of the reviewers...

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Gogl lab @teamgogl.bsky.social · 13/11/2025

According to ChatGPT, this is a three-stranded coiled coil.

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Gogl lab @teamgogl.bsky.social · 28/10/2025

profaff.fr The new ProfAff database is up and running. Although there are still many things to improve, it is a major upgrade.

profaff.fr

ProfAffv2 - Protein Affinity Database

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Gogl lab @teamgogl.bsky.social · 25/10/2025

This is great, so we are not the only one who saw this! But if this is a common observation, I am super puzzled why we find so many completely homogenous gfp localizations in the literature.

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Gogl lab @teamgogl.bsky.social · 24/10/2025

We are seeing this in multiple cell lines in confocal or TIRF microscopy. In the attached TIRF image you can see a non transfected cell with no GFP signal.

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Gogl lab @teamgogl.bsky.social · 24/10/2025

Bluesky, we need your help! Why does plain eGFP partially colocalize with actin filaments in cells? (No bleed-through, observed in multiple cell lines. Whole plasmid sequenced.) #FluorescenceFriday #Microscopy

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Gogl lab @teamgogl.bsky.social · 17/10/2025

Applicants should have a recent PhD completion (<6 months before recruitment) and proven skills in protein production and purification. 📍 Start: January | ⏳ 6-month contract (extendable)

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Gogl lab @teamgogl.bsky.social · 17/10/2025

The project focuses on mapping motif-mediated protein–protein interactions involved in key cellular processes like signaling and cancer, using cutting-edge biophysical interactomics approaches such as the native holdup assay.

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Gogl lab @teamgogl.bsky.social · 17/10/2025

The Quantitative Interactomics and Disease-Related Networks team at iBV (Nice, France) is recruiting a Postdoctoral Researcher with expertise in recombinant protein technologies and biochemistry.

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Gogl lab @teamgogl.bsky.social · 15/10/2025

The old ProfAff server served us well, but it’s time for an upgrade! Can’t wait to launch the new version from our new institute!

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Gogl lab @teamgogl.bsky.social · 05/09/2025

I am incredibly grateful to the ERC reviewers for their time and support. This recognition is a true honor and means a great deal to me. Excited to keep pushing forward the characterization of so-far unexplored motif-mediated protein–protein interactions!

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Gogl lab @teamgogl.bsky.social · 08/08/2025

GPT-5 seems like a pretty significant step towards PhD level. But a PhD-level researcher knows the literature, i.e., names of researchers and contents of key papers, much better. Or maybe it's only because we are working in a very niche field?

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Gogl lab @teamgogl.bsky.social · 26/06/2025

Today we got immediate desk rejection .... almost 8 weeks after submission! I think respectful journals could do better than this.

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Reposted by Gogl lab

Bogi @zbobo2.bsky.social · 12/06/2025

I’m thrilled to share that I have secured a permanent position within Section 20 of the CNRS. I will do my utmost to advance our understanding of the intricate interactome of transcription factors, an area of research I am deeply passionate about. 🎆

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Gogl lab @teamgogl.bsky.social · 12/06/2025

This is outstanding news for our lab, but maybe it's even more important in our personal lives! As an academic couple, we had to face the infamous #TwoBodyProblem. Not anymore, thanks to the French scientific system! Thank you @cnrs.fr and @inserm.fr for supporting us!#academiclife

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Gogl lab @teamgogl.bsky.social · 12/06/2025

Congratulations to Boglarka for obtaining a CNRS permanent position! 🎉🥂 She will start a new line of research in the Gogl lab focusing on the quantitative interactomics and biophysics of protein-DNA interactions and their consequences on transcription regulation and chromatin organization.

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Gogl lab @teamgogl.bsky.social · 10/06/2025

We like our proteins pure. This is the first #mCherry purification in the new lab. The next ones will be less colorful, I am afraid...

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Reposted by Gogl lab

Misha Kudryashev @mishakudryashev.bsky.social · 08/06/2025

We have a preprint for you EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...

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Gogl lab @teamgogl.bsky.social · 06/06/2025

Snapped the first real Gogl team photo just before our pétanque championship. Spoiler: Bogi won! 🏆 #TeamGogl #newPI

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Gogl lab @teamgogl.bsky.social · 05/06/2025

If it is only the ghosting, that can also happen in real life due to gel casting artifacts.

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Gogl lab @teamgogl.bsky.social · 29/05/2025

Every time our team needs to order something important, the university’s response is basically...

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Gogl lab @teamgogl.bsky.social · 27/05/2025

(And no, Bogi is not just sitting in the same spot doing experiments for 3 months. Sometimes she takes a short break...)

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Gogl lab @teamgogl.bsky.social · 27/05/2025

Also, if you scroll back to my past post from a few months ago, you can notice an incredible transformation in the lab. It is no longer a storage room, but a real lab!

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Gogl lab @teamgogl.bsky.social · 27/05/2025

Our brand new iD5 multi mode plate reader arrived from Molecular Devices! I cannot wait to see some data measured on it!

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Pedro Beltrao @pedrobeltrao.bsky.social · 02/05/2025

Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights: www.nature.com/articles/s41...

nature.com

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology

Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.

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Gogl lab @teamgogl.bsky.social · 28/03/2025

I would like to specially thank all our collaborators and friends who supported her in this path!

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