The evolution of the yeast, Saccharomyces cerevisiae, from a genetically tractable model organism to a chassis for genome-scale engineering represents one of the most influential trajectories in euka....

The Synthetic Yeast Genome Project (Sc2.0) set out to redesign and chemically synthesize an entire eukaryotic genome. This Comment summarizes the design- and construction-related defects revealed duri...

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.

Abstract. Pulcherriminic acid is an iron chelator produced by some Kluyveromyces and Metschnikowia yeasts. Its biosynthesis is encoded by the four–gene PUL

Scientists are developing technology to create the first synthetic human chromosome. The ability to write large genomes could transform our understanding of health.

The violin is smaller than a human hair and has "laid the groundwork" for future research.

Nuclei define eukaryotes, enabling macromolecular compartmentalization and cellular regulation. Each nucleus is believed to contain one or more haploid sets of chromosomes (1N). However, we discovered...

This inter-disciplinary project will apply advanced synthetic biology approaches and genomics to elucidate the genetic basis of protein secretion in yeast.