iiinova — where your digital self keeps evolving

Jake Wintermute @synbio1.bsky.social · 01/10/2026

“AI can’t possibly know everything about biotech because some of it is tacit knowledge you can only experience first hand.” The tacit knowledge:

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Reposted by Jake Wintermute

Mon Mothra @flobbert.bsky.social · 14/09/2026

gonna turn this into a midi controller and make some of the worst music you've ever heard in your life

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Jake Wintermute @synbio1.bsky.social · 14/09/2026

I'd like to get a 90s-era medical device console like this and install some kind of AI soundboard in it so it can be my sassy lab companion

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Jake Wintermute @synbio1.bsky.social · 15/07/2026

So funny when preclinical biotechs sign these big biobucks deals. Oh you're going to get a 20% royalty on annual net sales exceeding $1 billion? Buddy the fog is gonna consume us in 2027. The fog is coming. The fog is coming. The fog is coming

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Jake Wintermute @synbio1.bsky.social · 14/07/2026

Nobody there cares but I do it anyway

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Jake Wintermute @synbio1.bsky.social · 14/07/2026

Bsky: Academics enjoying a sensible chuckle X: Tech entrepreneurs dming me their plan to cure all diseases

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Jake Wintermute @synbio1.bsky.social · 13/07/2026

Everyone wants to cure all diseases but nobody wants to do no hard ass biology experiments

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Jake Wintermute @synbio1.bsky.social · 11/07/2026

Can anyone who played CELLQuest on the original Becton Dickinson tell me if it was fun? Is it worth trying to vibe code an emulator for some retro gaming?

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Jake Wintermute @synbio1.bsky.social · 27/05/2026

I look forward to the day when every lab instrument runs linux and the entire UI is just an MCP for my agents

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Jake Wintermute @synbio1.bsky.social · 13/05/2026

If weeds can overgrow a fake lawn then it stands to reason that you could develop a strain of grass that would functionally replace the fake lawn except be real

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Jake Wintermute @synbio1.bsky.social · 10/05/2026

refactoring the meatware stack

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Jake Wintermute @synbio1.bsky.social · 30/04/2026

How it feels to do biotech in 2026

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Jake Wintermute @synbio1.bsky.social · 28/04/2026

Bioproduct idea gluten-free damp dusters for the market of people with celiac disease who want to eat their scrub daddies

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Jake Wintermute @synbio1.bsky.social · 24/04/2026

I am literally begging you to start a biotech company, literally any biotech company, and incorporate slop maximalism into your branding I am in love with biotech slop maximalism. I will do free work for you. I will shill whatever bioproduct or AI model thing you sell.

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Jake Wintermute @synbio1.bsky.social · 20/04/2026

1) Apparently snails can eat graffiti 2) Apparently snails actively seek out graffiti to eat 3) ??? 4) Start a biotech company that sells snails for graffiti removal

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Reposted by Jake Wintermute

David Bikard @dbikard.bsky.social · 17/04/2026

Very proud of this work and all the efforts from my team and collaborators on this! You can now use DGRs for in vivo targeted hypermutagenesis in E. coli. We also included some early proof of concept in Yeast thanks to @seth-shipman.bsky.social !

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Jake Wintermute @synbio1.bsky.social · 12/04/2026

Is there a “Plasmidsaurus for experimental data?” What is the fastest, cheapest way to start offering services that scientists want? To answer these questions, we have to build the CORE americanwetware.substack.com/p/build-the-...

americanwetware.substack.com

What if you could tap into a continuous stream of biological data?

Why we should build an automated biology CORE that never sleeps

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Jake Wintermute @synbio1.bsky.social · 12/04/2026

In today’s post, I describe an engineering challenge that could bring scalable, on-demand services to other biotech operations.

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Jake Wintermute @synbio1.bsky.social · 12/04/2026

Biology services that are less versatile, but still scalable and on-demand, have proven value. DNA synthesis, strain banking and plasmid sequencing providers have accelerated science and found many happy customers.

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Jake Wintermute @synbio1.bsky.social · 12/04/2026

“Cloud labs” focus on versatility. A cloud compute server can do anything a computer can do. An analogous biology service would need to execute all possible biology lab protocols - a profoundly ambitious vision.

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Jake Wintermute @synbio1.bsky.social · 12/04/2026

Cloud computing is a good product: versatile, scalable, on-demand. Biotech service providers have tried to reproduce this formula. But what if we’ve been focusing on the wrong features?

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Jake Wintermute @synbio1.bsky.social · 11/04/2026

I will personally award the Nobel Prize in Chemistry to the first person who engineers a peptide that can do the worm

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Jake Wintermute @synbio1.bsky.social · 11/04/2026

Hands-free lab automation solves this problem

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Jake Wintermute @synbio1.bsky.social · 09/04/2026

We know that AI increases the value of human biological data. But by how much? Super interesting to see a specific class of human biological data assigned a spot price in a real market event

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Jake Wintermute @synbio1.bsky.social · 08/04/2026

Lab coats should have elastic scrunchies on the sleeves

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Jake Wintermute @synbio1.bsky.social · 06/04/2026

16 years ago I blew off my thesis research for one day to make a YouTube video about plasmids www.youtube.com/watch?v=pNeC... Today I'm in the plasmid sequencing tutorials for Plasmidsaurus www.youtube.com/watch?v=pNeC... The trick to having a fun career in science is say yes to random fun things

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Jake Wintermute @synbio1.bsky.social · 24/03/2026

Me when I click on an in-line citation in an online article and it takes me to the references section of the same article instead of opening the new article in a new tab

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Jake Wintermute @synbio1.bsky.social · 25/02/2026

We’re so blessed that evolution made the shape of eggs be the literal only possible shape for eggs that isn’t deeply unsettling

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Jake Wintermute @synbio1.bsky.social · 24/02/2026

Biotech startups 0.0003 nanoseconds after the lab team ships a breakthrough drug to clinical trials

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Jake Wintermute @synbio1.bsky.social · 22/02/2026

The funniest version of the future is the one where we invent ASI only to watch it immediately start culturing brain cells to invent ASSI www.cell.com/cell-reports...

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Jake Wintermute @synbio1.bsky.social · 05/02/2026

Have fun in the small pumpkin underclass losers

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Jake Wintermute @synbio1.bsky.social · 02/02/2026

Me and everyone who keeps calling it Pichia pastoris holding out against the attempt to rename it Komagataella phaffii

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Jake Wintermute @synbio1.bsky.social · 01/02/2026

How it feels to start opening tabs on a new research project

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Jake Wintermute @synbio1.bsky.social · 30/01/2026

There are still some good gene splicer jobs

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Jake Wintermute @synbio1.bsky.social · 29/01/2026

You must assemble the 4 lost parafilms of type "L," "N," "O" and "P"

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Jake Wintermute @synbio1.bsky.social · 27/01/2026

The children yearn for bioproducts

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Jake Wintermute @synbio1.bsky.social · 27/01/2026

I'll give you the secret tech for good popcorn: nutritional yeast

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Jake Wintermute @synbio1.bsky.social · 27/01/2026

The good version of the future includes a decentralized bioeconomy supporting lots of good green-collar jobs in bioproducts and bioservices Sourdough microbakeries hint at what that future might look like www.nytimes.com/2026/01/26/d...

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Jake Wintermute @synbio1.bsky.social · 26/01/2026

If you had an LLM from the year 3000 and a writer's room of all the greatest communicators in history you could never invent a more worthless and confusing name for a statistical technique than "Design of Experiments"

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Jake Wintermute @synbio1.bsky.social · 26/01/2026

The fancy popcorn from the organic market is bad at popping compared to the cheap popcorn from the normal grocery store and I’m tired of pretending it’s not

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