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Reposted by Stanley E. Strawbridge

Development, Regeneration and Neurophysiology @drn-sheffield.bsky.social · 17/06/2026

Today we welcome Professor Jenny Nichols (University of Edinburgh), who will talk about her work on early mammalian development. Host: Stan Strawbridge @stanleystrawbridge.bsky.social All welcome!

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 05/05/2026

Very happy to have been part of such a fun and interesting project with an excellent team!

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 24/04/2026

We view cell-state transition as analogous to system failure and argue that kinetics are a phenotype. The model separates four features: onset delay, timescale, shape, and competent fraction. We apply it to pluripotency exit, directed differentiation, and reprogramming. 🧵 2/3

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 24/04/2026

🚨 New Preprint 🚨 "Quantification and statistical comparison of cell-state transition kinetics using a parametric failure-based model" doi.org/10.64898/202... Cells do not usually change state at a single fixed time. How can we compare these distributions across conditions? 🧵 1/3

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 14/01/2026

Very similar gig at 123 Pleasant Street in Morgantown, WV, by Mustard Plug back in 2008/9ish. Much Skanking.

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 06/01/2026

⏰ Deadline Approaching! ⏰ 📅 15 January 2026 Under two weeks to apply for our fully funded PhD project “Engineering an in vitro human embryo implantation platform to study pathologies arising in early pregnancy” at @sheffielduni.bsky.social. #development #endometrium #materialsscience

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 17/11/2025

⏰ Deadline in two weeks! ⏰ Work at the interface of biology + computation to build a virtual human embryo to predict developmental success and failure. Happy to answer questions!

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Reposted by Stanley E. Strawbridge

Rory Cooper @rorylcooper.bsky.social · 03/11/2025

🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬 This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share! www.findaphd.com/phds/project... 🧪

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 01/07/2025

Do you make shipments?! I’d love this for the lab!

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 24/06/2025

Finally, a career highlight, we made it into @cellysally.bsky.social 's #PaperThemeTune s: bsky.app/profile/cell... [8/8]

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 24/06/2025

Also, check out the behind-the-scenes interview on my path in science, a eureka moment, and what I do when I choose to leave the lab: 🎙️ doi.org/10.1242/dev.... [7/8]

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 24/06/2025

To test this, we built a quantitative model of fate specification in the embryo. It predicts a two-step mechanism: 1️⃣ Physical exclusion 2️⃣ FGF4-driven fate bias And it even works at the level of individual embryos! [4/8]

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 24/06/2025

Even ESCs lacking FGF4 can push host cells into the trophectoderm, just by outcompeting them for space. But with FGF4, they also bias host cells away from contributing to the embryo. ➡️ Crowding first, then signalling. [3/8]

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 24/06/2025

When injected into 8-cell embryos, ESCs displace host cells from the future embryo into extra-embryonic tissues. This happens via physical crowding and, if the donor cells produce FGF4, also via molecular signalling. [2/8]

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 24/06/2025

🚨 New paper out in Development! 🚨 We show that donor embryonic stem cells (ESCs) reshape the developing mouse embryo, not just by what they signal, but where they push. 📄 doi.org/10.1242/dev.... [1/8]

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 12/06/2025

I’ve been using my CoB insulated lunch bag for work ever since Biologist @ 100 in Liverpool! 🤓

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 04/06/2025

7/10 Somatic versatility Capacitated cultures then generate neuroectoderm, paraxial mesoderm & definitive endoderm with textbook marker profiles—ready for downstream lineage studies.

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 04/06/2025

6/10 Forward Progression 10-day XAV capacitation guides naïve domes → primed flats—an in-vitro window on the pre- to post-implantation transition.

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 04/06/2025

5/10 Extra-embryonic power PD03 + A83 + Y → GATA3⁺ trophoblast cysts. LIF + ACTIVIN + CHIR → hypoblast/ExEn. Use them for blastoids or placenta work.

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 04/06/2025

4/10 Hallmark naïve identity Lines keep the classic naïve signature, form domes in t2iLGöXYaa, and map to E5/6 epiblast by bulk RNA-seq.

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 04/06/2025

3/10 Mosaicism in a dish Two triplet sets showcase natural variation: • 161.2A/C share a Chr2q deletion, 161.2B does not. • 255.1B/C carry Chr5 trisomy, 255.1A does not. Study how karyotype skews lineage choice—no embryos needed.

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 04/06/2025

2/10 Multiple clones per embryo Instead of one line per blastocyst, we expanded every dome-shaped colony. Result: single embryos now come with paired, triplet or quadruplet lines—perfect for side-by-side comparisons.

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 04/06/2025

1/10🧵 New preprint! 🚀 We built a resource of 20 clonal human naïve pluripotent stem cell lines from 10 blastocysts. Explore embryo-to-embryo and clone-to-clone variation in one place. 👉doi.org/10.1101/2025.06.02.657331

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Reposted by Stanley E. Strawbridge

Development, Regeneration and Neurophysiology @drn-sheffield.bsky.social · 28/05/2025

Today’s speaker in our DRN external seminar series is Dr Thorsten Boroviak (PDN, University of Cambridge) @pdncambridge.bsky.social , who will talk on early embryonic development in primates. Host: Anestis Tsakiridis @tsakiridis.bsky.social All welcome!

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 19/05/2025

Thanks to Anne Wiblin and the team at abcam for the invitation to share and discuss my research today! #stemcells #development

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 19/05/2025

It was fantastic to have @lbates.bsky.social visit last week! Thank you for sharing your exciting work!

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Reposted by Stanley E. Strawbridge

Rory Cooper @rorylcooper.bsky.social · 21/03/2025

Check out these feather buds on the chicken embryo's wing! Our latest study @plosbiology.org reveals that temporary inhibition of sonic hedgehog signalling transforms feathers into simple, protofeather-like structures—similar to those of their dinosaur ancestors🔬🦖🧪 journals.plos.org/plosbiology/...

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 15/03/2025

A fantastic meeting of early career researchers in Vienna this week. It was great to see old friends and to meet new people. Thank you so much for the opportunity to present my work at SY-Stem 2025! @impvienna.bsky.social @imbavienna.bsky.social @maxperutzlabs.bsky.social

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 10/03/2025

Thank you!!! @drn-sheffield.bsky.social and @sheffielduni.bsky.social has been and continues to be a welcoming and stimulating research environment!

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Reposted by Stanley E. Strawbridge

Development, Regeneration and Neurophysiology @drn-sheffield.bsky.social · 10/03/2025

A warm welcome to Stanley Strawbridge @stanleystrawbridge.bsky.social, who joins us as a #PhysicsOfLife & #QuantitativeBiology Fellow from @scicambridge.bsky.social. His work explores early human embryo form and function. #AdvancedImaging #AppliedMathematics #Bioengineering #stemcells #development

Mid-blastocyst stained for the three lineages [Epiblast (green, NANOG), Hypoblast (red, GATA4), and Trophoblast (blue, GATA3)

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 09/03/2025

It was great to be back @cambridgeuni.bsky.social to give a talk @gurdoninstitute.bsky.social Developmental Biology Seminar Series, and to talk science with people from @scicambridge.bsky.social, @loke-ctr.bsky.social, and @mrclmb.bsky.social! Spring has sprung @christscollegecam.bsky.social!

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Reposted by Stanley E. Strawbridge

Surfin' NuRD @surfinnurd.bsky.social · 07/11/2024

Fully funded #PhD Studentship with myself and JJ Phillips at the Living Systems Institute, @uniofexeter.bsky.social "Control of chromatin remodeller activity to direct cell fate decisions" #Chromatin #Transcription #StemCells #StructuralBiology Please re-skeet! www.exeter.ac.uk/research/ins...

exeter.ac.uk

LSI PhD programme | Living Systems Institute | University of Exeter

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Reposted by Stanley E. Strawbridge

LSI-Exeter @lsiexeter.bsky.social · 02/12/2024

PhD positions available in the LSI www.exeter.ac.uk/research/ins... via the Wellcome Trust funded GW4 CAT PhD Programme for Health Professionals. Applications open now until 17.January 2025. @uniofexeter.bsky.social

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Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 28/11/2024

🚨 A PhD project to develop an in vitro human implantation platform is available with me and an interdisciplinary supervisory team at the University of Sheffield. #blastoids #endometrialAssembloids #stemCellBiology #embryology #biomaterials #advancedImaging #dataScience tinyurl.com/ycykmwv4

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