In this Perspective, George Davey Smith and colleagues outline how and why gene-environment equivalence, the fundamental principle of Mendelian Randomization (MR), must be properly applied and critica...

Nature Reviews Genetics, Published online: 24 February 2026; doi:10.1038/s41576-026-00948-0Chikashi Terao recalls a paper by Loh et al., which introduced a highly sensitive algorithm to detect low-fraction chromosomal mosaicism from SNP array data, enabling large-scale mapping of clonal haematopoiesis.