Serge Parel @spparel.bsky.social · 06/09/20261/ Fine-tuned a small local model (Qwen2.5-7B, QLoRA) to curate hERG assay data from ChEMBL. The accuracy gain isn't the interesting part. The failure is. 110
Reposted by Serge ParelDerek Lowe @dereklowe.bsky.social · 31/08/2026The (alleged) dimethylmercury incident at MIT: thoughts based on whywe know so far:science.orgThe Alleged Dimethylmercury Incident 811332
Serge Parel @spparel.bsky.social · 31/08/2026Eastern cauliflower mushroom Chicken of the woods Giant polypore Tuberous polypore #MushroomMonday 030
Serge Parel @spparel.bsky.social · 19/07/20261/ Three real machines from the past 90 days: a $1,740 garage rig on a decade-old server board serving a 30B coder at full speed, a MacBook running a 397B model streamed from SSD, and eight H200s running MIT-licensed weights that beat Claude Opus 4.8 on Terminal-Bench. 100
Serge Parel @spparel.bsky.social · 12/07/20261/ Your GPU is mostly waiting. A 70B model at 4 bits is ~35 GB of weights, all read per token. At 128 GB/s of bandwidth that caps you at 3.5 tok/s. The teraflops never enter the equation. This is the memory wall, and every 2026 inference speedup is a way around it. 100
Serge Parel @spparel.bsky.social · 30/06/20261/ Everyone's chasing bigger models. DeepSeek shipped something quieter that might matter more: DSpark. No new flagship, no reasoning breakthrough. Just their existing V4 stack running 60–85% faster, with zero quality loss. How it works 🧵 100
Reposted by Serge ParelMrs. Betty Bowers @mrsbettybowers.bsky.social · 30/06/2026First, the White House doesn't date back to July 4, 1776, idiot. It opened on November 1, 1800. Second, the tackiest man in the United States and its president should *not* be the same person. Third, nice inspiration, fascist. 28154441466
Serge Parel @spparel.bsky.social · 27/06/20261/8 Earlier this year you could buy a Mac Studio with 512GB of unified memory. Today the top config maxes out at 96GB. The high-memory machines didn't just get pricier. They quietly disappeared. Here's what's happening with the 2026 memory crisis 🧵 101
Serge Parel @spparel.bsky.social · 14/06/20261/ 5:21 PM Eastern, Friday June 12. The US government picked up a phone and shut down the most capable AI model anyone had ever used. Globally. For everyone. Including the foreign-national researchers who built it. I spent the weekend digging in. 🧵 111
Reposted by Serge ParelNPR @npr.org · 01/06/2026A study finds that an mRNA vaccine is highly effective at preventing recurrence of this dangerous skin cancer, when used in combination with Keytruda, an immunotherapy drug. n.pr/4u3FHCZn.prA cancer vaccine made just for you. mRNA is back and it's fighting melanomaA study finds that an mRNA vaccine is highly effective at preventing recurrence of this dangerous skin cancer, when used in combination with Keytruda, an immunotherapy drug. 141235379
Serge Parel @spparel.bsky.social · 01/06/2026Reaction prediction models are only as good as the reaction data they learn from. This paper is worth a look: CompleteRXN: Toward Completing Open Chemical Reaction Databases 1/5 arxiv.org/html/2605.00...arxiv.orgCompleteRXN: Toward Completing Open Chemical Reaction Databases 121
Serge Parel @spparel.bsky.social · 26/05/20261/ Uber burned its entire 2026 AI budget by April. ServiceNow did the same. KPMG says U.S. orgs project $207M average AI spend over the next 12 months — nearly 2x last year. The all-you-can-eat era of AI coding tools is over. The deadline matters. 111
Serge Parel @spparel.bsky.social · 26/05/2026Agent “skills” may be the next serious optimization layer. SkillOpt treats a reusable best_skill.md not as static documentation, but as something you can train. Frozen agent runs tasks → optimizer reviews traces → proposes bounded skill edits → held-out eval accepts only improvements. 100
Serge Parel @spparel.bsky.social · 16/05/2026Festus, Missouri just removed every council member who approved a $6B AI data center. All four. Gone. 70% of Americans now oppose data centers in their local area. That's already past the peak opposition to nuclear power plants. Ever. The tech industry calls it NIMBYism. They're misreading it. 120
Serge Parel @spparel.bsky.social · 12/05/2026When a metric becomes the target… www.tomshardware.com/tech-industr...tomshardware.comAmazon employees admit to using AI unnecessarily to pump up internal usage scores — workers complain of intense pressure to use AI toolsEmployees at Amazon, Meta, and Microsoft have been gaming AI usage metrics. 000
Serge Parel @spparel.bsky.social · 10/05/2026102 organic chemists shown real vs AI-generated molecules. Couldn't tell them apart — 62% accuracy ≈ random. That's CoCoGraph: graph diffusion with 100% chemical validity, 534K params vs 4.6M for comparable models. Constraints in the math, not the model. www.nature.com/articles/s42...nature.comA collaborative constrained graph diffusion model for the generation of realistic synthetic molecules - Nature Machine IntelligenceThe collaborative constrained graph diffusion model CoCoGraph generates novel molecules that are guaranteed to be valid and more realistic than state-of-the-art outputs, while achieving faster perform... 041
Serge Parel @spparel.bsky.social · 03/04/2026K-Dense released 134 scientific skills for AI coding agents, incl. #rdkit, molecular property prediction, VS, ADMET analysis, molecular docking. Open source, works with Claude Code/Cursor/Codex… github.com/K-Dense-AI/claude-scientific-skills #cheminformatics #RDKit #AIagents #drugdiscoverygithub.comGitHub - K-Dense-AI/claude-scientific-skills: A set of ready to use Agent Skills for research, science, engineering, analysis, finance and writing.A set of ready to use Agent Skills for research, science, engineering, analysis, finance and writing. - K-Dense-AI/claude-scientific-skills 240
Serge Parel @spparel.bsky.social · 31/03/2026Anthropic leaked Claude Code source to npm. KAIROS (unreleased autonomous agent), "Undercover mode" (AI hides it's AI), and irony that their own AI-written toolchain caused it. "A significant portion was probably written by the AI you're shipping." 220
Serge Parel @spparel.bsky.social · 16/03/2026Billionaire Howard Marks questioned if AI was a bubble. Then he watched it build itself. Level 3 arrived: AI gets goals, not instructions. Your survival: Pivot to novelty, cultivate judgment, become the orchestrator. #AI #AutonomousAgents #TechInnovation medium.com/activated-th...medium.comThe Trillion-Dollar AI Illusion: A Billionaire Investor’s Warning on the Autonomous Agent EraLegendary investor Howard Marks questioned if AI was a financial bubble. Then he watched it build itself. Here is why the tech market and… 000
Serge Parel @spparel.bsky.social · 23/02/2026"...if you’re typing natural language prompts into Claude Code 🧑💻 and hoping for the best, you’re rolling dice too. Except the dungeon master is an AI with zero context and infinite confidence." #AI #PromptEngineering #Coding #VibeCoding #ClaudeCode #Opencode medium.com/p/i-stopped-...medium.comI Stopped Vibe Coding and Started “Prompt Contracts” — Claude Code Went From Gambling to ShippingLast Tuesday at 2 AM, I deleted 2,400 lines of code that Claude Code had just generated for me. 010
Serge Parel @spparel.bsky.social · 01/02/2026Me: "I'll just try @OpenClaw for a quick task" *48 hours later:* My AI has extracted 46 plant care guides from OneNote, filed a bug report on Moltbook, and is tracking my bloodwork trends. I have created a monster. A very organized monster. ???? 000
Reposted by Serge ParelMarkus Barth @markusbarth.bsky.social · 05/01/2026Wenn du Dinge, die Donald Trump macht, „sehr komplex“ findest, dann möchte ich dir nicht beim Schuhebinden zuschauen müssen. 19973218
Serge Parel @spparel.bsky.social · 29/12/2025Scarlet cup Juda’s ear Brick cap Red-belted conk #mushroommonday 030
Serge Parel @spparel.bsky.social · 22/12/2025Oyster mushroom Yellowing curtain crust Turkey tail #MushroomMonday 040
Serge Parel @spparel.bsky.social · 15/12/2025Varnished conk Tinder fungus Lumpy bracket #MushroomMonday 010
Serge Parel @spparel.bsky.social · 12/11/2025On a scale of 1 to “invading Russia in winter”, how stupid was this idea ? #neom #TheLine www.heise.de/en/news/Mega...heise.deMegaproject The Line has likely failedConstruction on the 170-kilometer-long city of The Line has stopped. However, the megaproject is still being pursued by officials. 020
Serge Parel @spparel.bsky.social · 01/11/2025bbc.com/future/artic...bbc.comLouvre robbery: Could a 50-year-old maths problem have kept the museum safe?An audacious heist at the Louvre saw thieves make off with priceless crown jewels in broad daylight – here is how a decades-old geometry problem can help museums boost their security. 020
Serge Parel @spparel.bsky.social · 20/10/2025Common ink cap Horn of plenty False chanterelle White saddle #MushroomMonday 030
Reposted by Serge ParelPrune60 @prune602.bsky.social · 20/10/2025Meanwhile in Russia… “The naked arsonist who set fire to the canopy of a tuberculosis dispensary turned out to be a patient with a criminal past.” What a headline www.fontanka.ru/2025/10/19/7... 1017718
Serge Parel @spparel.bsky.social · 20/10/2025Maybe hosting half the internet in one single place in Virginia might not be a good idea… 😂 #awsdown www.bluewin.ch/en/news/thou...bluewin.chThousands of websites report massive disruptionNumerous online services were temporarily offline on Monday morning. This was due to a serious outage at Amazon Web Services (AWS), which paralyzed several global platforms - from Snapchat to Fortnite... 010
Serge Parel @spparel.bsky.social · 13/10/2025Rosy russula Dark fieldcap False saffron milkcap Porcelaine mushroom #MushroomMonday 021
Serge Parel @spparel.bsky.social · 10/10/2025Twig parachute Psathyrella pennata (a species of brittlestems) Gray coral Pleated inkcap #FungiFriday 000
Serge Parel @spparel.bsky.social · 06/10/2025Fluted bird’s nest Amethyst deceiver Violet webcap Collared earthstar #MushroomMonday 061
Serge Parel @spparel.bsky.social · 29/09/2025Fringed earthstar False turkey-tail Slimy spike Fairy inkcap #mushroommonday 041
Serge Parel @spparel.bsky.social · 26/09/2025Shaggy mane Parasol Freckled dapperling King Alfred’s cake #fungifriday 0171
Serge Parel @spparel.bsky.social · 29/08/2025Freckled dapperling Devil’s fingers Cauliflower mushroom #FungiFriday 0131
Reposted by Serge ParelHenry Morris @mrhenrymorris.substack.com · 29/08/2025Full recent PNG article. (New subs remain welcome) 18123
Reposted by Serge ParelThe Tennessee Holler @thetnholler.bsky.social · 16/08/2025FOX REPORTER: “The way it felt in the room was not good. It did not seem like things went well. It seemed like Putin came in and steamrolled, got right into what he wanted to say, got his photo next to the president, then left.” 879147614117
Reposted by Serge ParelParody Nigel Farage @parodypm.bsky.social · 16/08/2025Quick summary of the Alaska Summit: -Putin played Trump like a fat orange fiddle - - er... that's it 1138641
Reposted by Serge ParelParody Nigel Farage @parodypm.bsky.social · 16/08/2025So it sounds like Trump is going to give Putin another two weeks, on top of the ten days he gave him instead of the original 50 days he gave him, after the two weeks he gave him following the first two weeks he gave him. TACO Trump strikes again. 1645786
Serge Parel @spparel.bsky.social · 15/08/2025Beyond the hype: is #ModelContextProtocol enterprise-ready? #AIInfrastructure #MCP #DistributedSystems #EnterpriseAI #RPCProtocols #AIIntegration #SoftwareEngineering #AITools #EnterpriseArchitecture #TechStandards #ProtocolDesign #AIEngineering julsimon.medium.com/why-mcps-dis...julsimon.medium.comWhy MCP’s Disregard for 40 Years of RPC Best Practices Will Burn EnterprisesFool me once, shame on you; fool me twice, shame on me. 010
Serge Parel @spparel.bsky.social · 15/08/2025Umbrella polypore Common stinkhorn Old man of the woods Sulphur tuft #FungiFriday 0141
Serge Parel @spparel.bsky.social · 04/08/2025Cinnabar-red polypore Red cracking bolete King bolete Yellow stagshorn #MushroomMonday 010
