iiinova — where your digital self keeps evolving

Reposted by @special-k.bsky.social

Waggoner Lab @labwaggoner.bsky.social · 03/04/2026

Before immune system maturation, enteroendocrine cells regulate early-life gut function by controlling the microbiota through IL-22 @science.org www.science.org/doi/10.1126/...

175

Reposted by @special-k.bsky.social

Guillaume Thibault @gthibault.bsky.social · 17/01/2026

We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing. It’s not a toxin. It’s metabolism. The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place. doi.org/10.1126/sciadv.aeb5297

doi.org

Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing

E. faecalis EET generates ROS, which induces the UPR in keratinocytes, inhibiting in vitro migration.

35220

Reposted by @special-k.bsky.social

Kimberly Kline 🏔 @kimingeneva.bsky.social · 17/01/2026

Enterococcus fans: Check out our latest on E. faecalis EET, advancing our understanding of both the fundamental physiology of this bug and new mechanisms of its virulence. This is the product of a thrilling collaboration with friends in Singapore @gthibault.bsky.social led by @aarontan.bsky.social.

15124

Reposted by @special-k.bsky.social

Saori Abe @oriabe114.bsky.social · 10/03/2025

www.science.org/doi/10.1126/... Research highlight📖 “…colonizing the gut of autoimmune-prone mice with E. gallinarum led to dissemination of living E. gallinarum to the lymph nodes, liver, and spleen, accompanied by ⬆️TH17 cells at these sites and production of anti-RNA #autoantibodies. “

science.org

Trouble at the border: An invading gut bacterium can break tolerance to self-RNA

Mouse anti-RNA antibodies triggered by gut E. gallinarum correlate with self-RNA autoantibodies and lupus severity in humans.

0134

special-k.bsky.social @special-k.bsky.social · 08/02/2025

Have you ever wondered how pathobionts contribute to autoimmunity? In this week's issue of Science Translational Medicine @science.org we elucidate the mechanism how E.gallinarum influences systemic immune responses and aggravates autoimmunity.. #ImmunoSky #Microbiome www.science.org/doi/10.1126/...

science.org

Translocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA–directed autoimmunity in mouse and human

Translocating pathobiont Enterococcus gallinarum promotes human TH17 and anti-RNA IgG3 autoantibody responses in patients with autoimmune disease.

3219