AMPA receptors mediate the majority of excitatory neurotransmission. Here, the authors report structural and functional regulation of GluA2 AMPA receptor by inhibitory auxiliary subunits GSG1L and TARP γ5 and by epilepsy-associated disease mutations.

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Combining rational drug design, functional studies, and cryo-EM, researchers characterize a selective TRPV1 agonist that promotes desensitization and prolonged pain relief.

Ion-channel conductance levels are controlled by the bending patterns of pore-forming transmembrane helices in the heterotetrameric neuronal channel GluN1a-2B N-methyl-D-aspartate receptor.

Native AMPA receptors are heteromeric complexes of GluA1-4 and auxiliary subunits. Here, authors report structures of the most abundant GluA1/A2 core in the closed, open, and desensitized states, allo...

The claudin subfamily family member Cldn24 is identified as an AMPAR auxiliary subunit.

TRPM3 is an ion channel that helps the body sense heat and contributes to pain. The authors show that both heat and small chemical molecules switch it on through similar changes inside the protein.

Pentameric ligand-gated ion channels (pLGICs) are vital neurotransmitter receptors that are key therapeutic targets for neurological disorders. Alt...

Opening of the NMDA receptor involves bending of the helices lining the ion channel gate.

Vega-Gutiérrez et al. present cryo-electron microscopy structures of GluA4-containing AMPA receptors, which are key for brain signaling. They show GluA4-specific conformations and explain how subunit ...