Discover how St. Jude researchers uncovered how regional differences in the developing brain shape diffuse midline glioma formation.

Here authors report that histone H3.3 K27M mutations drive diffuse midline glioma by ablating intrinsic regional differences in oligodendrocyte development, selectively expanding immature oligodendroc...

Discover how St. Jude researchers uncovered how regional differences in the developing brain shape diffuse midline glioma formation.

Explore how St. Jude researchers helped usher in the era of sequencing into diagnostics for pediatric cancers, overcoming previous challenges and limitations.

The Pediatric Oncology Education (POE) program is a summer internship in laboratory or clinical research at St. Jude.

Learn how St. Jude scientists use epigenetics research to uncover vulnerabilities that can be used to treat neurologic disease, cancer, and blood disorders.

See how St. Jude researchers are using epigenetics to better understand how to diagnose and treat pediatric brain tumors.

Nature Reviews Cancer, Published online: 10 April 2026; doi:10.1038/s41568-026-00930-2In a recent study, Gudenas et al. map pineoblastoma subgroups to pinealocyte progenitors and identify a shared photoreceptor-like transcriptional network across pineoblastoma, retinoblastoma and group 3 medulloblastoma, revealing a developmental vulnerability with therapeutic potential.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10270-8 Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of such tumours despite ‘quiet’ genomes.

Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of...

In this issue of Cancer Cell, Gudenas et al. reveal that Group 3 medulloblastoma, pineoblastoma, and retinoblastoma converge on a shared tumor-associated photoreceptor signature rooted in transient developmental progenitors. This work reframes these malignancies as diseases of common developmental vulnerability and identifies shared transcriptional dependencies with potential therapeutic relevance.

Pineoblastoma is an aggressive childhood brain cancer. Using single-cell transcriptomics of patient tumors, developing pineal gland, and engineered models, Gudenas et al. identify pinealocyte progenit...

Smith et al. present M-PACT, a deep neural network leveraging low-input cell-free DNA methylation profiles to achieve robust classification of pediatric brain tumors and enable cellular deconvolution ...

See how M-PACT, an AI-powered algorithm can sift through ctDNA in cerebrospinal fluid and molecularly classify tumors based on their DNA methylation pattern

Find how St. Jude researchers discovered a new way to group patients with medulloblastoma, which could lead to major reduction in treatment-related toxicity.

In single cell biology, the complexity of tissues may hinder lineage cell mapping or tumor microenvironment decomposition, requiring digital dissociation of bulk tissues. Many deconvolution methods focus on transcriptomic assay, not easily applicable to other omics due to ambiguous cell markers and reference-to-target difference. Here, we present MOADE, a multimodal autoencoder pipeline linking multi-dimensional features to jointly predict personalized multi-omic profiles and cellular compositions, using pseudo-bulk data constructed by internal non-transcriptomic reference and external scRNA-seq data. MOADE is evaluated through rigorous simulation experiments and real multi-omic data from multiple tissue types, outperforming nine deconvolution pipelines with superior generalizability and fidelity.

Arabzade, Shirnekhi, Varadharajan, Ippagunta and colleagues show that the zinc finger translocation-associated (ZFTA) fusion oncoproteins gain intrinsically disordered regions, inducing nuclear conden...

Discover research showing that small disordered regions of a fusion protein creates droplets called condensates that are essential to ependymoma development.