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Simon Bayly

@simonbayly.bsky.social
1.5K followers 864 following 2.1K posts

Reformed chemist 👨‍🔬 IP licensing and spinouts at the Francis Crick Institute. Also post about cycling 🚲 Opinion my own etc.

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Simon Bayly @simonbayly.bsky.social · 1h
Surprise winners and actual chemists too!
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Matthew Cobb @matthewcobb.bsky.social · 06/10/2026
A lot of excitement on here about the article in Science summarising the discoveries of @alistairsponsel.bsky.social and Brian Sutton, just published in the Journal of the History of Biology. Some people have asked, so here is what I think they show, and what are the implications:
link.springer.com
Photograph 49 is the Key to Understanding the History of Rosalind Franklin’s DNA Photograph 51 - Journal of the History of Biology
This essay, co-authored by a historian of science and an X-ray crystallographer, sheds new light on Rosalind Franklin’s Photograph 51. We refute the infamous claim that, unlike James Watson, Franklin ...
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Geoff Brumfiel @gbrumfiel.bsky.social · 06/10/2026
The IceCube neutrino detector has won the 2026 Nobel Prize in physics. The Trump administration has proposed slashing its budget in half in 2027.
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Simon Bayly @simonbayly.bsky.social · 06/10/2026
I remember that paper!
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Simon Bayly @simonbayly.bsky.social · 06/10/2026
Looks like an interesting technique though.
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Simon Bayly @simonbayly.bsky.social · 06/10/2026
Todays tortuous scientific acronym award goes to: www.biorxiv.org/content/10.6...
biorxiv.org
SHERLOCK: Structured representation learning and causal inference of downstream perturbation effects
Understanding the effects of genetic, molecular, and experimental perturbations is essential for decoding cellular mechanisms and guiding biomedical interventions. Existing computational approaches ar...
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Simon Bayly @simonbayly.bsky.social · 06/10/2026
And then blaming it on social media!
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Kindra Crick 🧩 @kindracrick.com · 05/10/2026
One of today’s Nobel Prize winners, Karl Deisseroth, said he was inspired by Francis Crick’s original call for precision targeting of neurons in a Scientific American called "Thinking about the Brain" and kept a copy of the original 1979 issue on his desk. 🧪 stanfordmag.org/contents/new...
stanfordmag.org
New Light on the Brain
By combining genetics with fiber optics, Karl Deisseroth has given researchers a powerful tool with which to probe our most enigmatic organ.
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Simon Bayly @simonbayly.bsky.social · 05/10/2026
Medicine Nobel goes to two biophysicists and a neuroscientist
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Simon Bayly @simonbayly.bsky.social · 03/10/2026
Apparently UK companies can access the EU’s Scaleup Europe Fund, but nobody realised www.researchprofessionalnews.com/rr-news-uk-i...
researchprofessionalnews.com
Multibillion EU Scaleup Fund can support UK companies - Research Professional News
Pre-Christmas summit could also see British access to European fund for growing technology startups expand
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Nicolas @nicolasn.bsky.social · 02/10/2026
This was gallium corrole, and the NMR was quite good. Rarely I see pyrrole peaks so resolved in 300 MHz. #realtimechem #fluorescencefriday #chemsky
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Simon Bayly @simonbayly.bsky.social · 02/10/2026
That it’s possible is intriguing, but ultimately it’s pointless
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Simon Bayly @simonbayly.bsky.social · 02/10/2026
Restore’s Holborn by-election ‘literature’ directly targets Reform voters.
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Simon Bayly @simonbayly.bsky.social · 02/10/2026
Borked bottom bracket?
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Michael E. Mann @michaelemann.bsky.social · 01/10/2026
First of two events I'll be doing in the U.K. during the week of Oct 12 | "Insight lecture" on #ScienceUnderSiege at the #CrickInstitute in London, 4pm Wed Oct 14: michaelmann.net/events/scien...
michaelmann.net
Science Under Siege (The Francis Crick Institute, London, UK) | Michael E. Mann
Science Under Siege   From pandemics to the climate crisis, humanity faces tougher challenges than ever. Whether it’s the health of our people or the health […]
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Simon Bayly @simonbayly.bsky.social · 30/09/2026
ALT text: “a blue globular protein remains oblivious as a strand of beige spaghetti nonchalantly caresses its left extremities“
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Simon Bayly @simonbayly.bsky.social · 01/10/2026
New posdoctoral fellowship programme at the @crick.ac.uk just dropped. Some very cool projects on the list: www.crick.ac.uk/careers-and-...
crick.ac.uk
PACE fellowships projects
Learn more about the PACE collaborative postdoc projects.
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Rowan Gardner @handle.invalid · 01/10/2026
The latest #biologymatters podcast is up. Thank you to those who said it is helpful. Steve and I discuss how the community helped us understand the challenges of #longCOVID and #MECFS and why @precisionlife.bsky.social is offering a Post COVID DNA Wellness Report. 🧬 www.youtube.com/watch?v=m9iY...
youtube.com
Long COVID and ME/CFS Are Not One-Size-Fits-All: What Genetics Is Revealing
YouTube video by PrecisionLife
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Simon Bayly @simonbayly.bsky.social · 30/09/2026
ALT text: “a blue globular protein remains oblivious as a strand of beige spaghetti nonchalantly caresses its left extremities“
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The Francis Crick Institute @crick.ac.uk · 29/09/2026
We're looking for undergraduate students at UK universities who are interested in scientific research to join one of our labs or facilities for 12 months as part of our sandwich student programme. Apply by 6 October: www.crick.ac.uk/careers-and-study/s…
crick.ac.uk
Sandwich students
Sandwich students join one of the Crick’s research groups or science technology platforms for 12 months to work on a research project.
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Simon Bayly @simonbayly.bsky.social · 29/09/2026
In plasma there are median 11 proteoforms per protein! 🤯https://www.biorxiv.org/content/10.64898/2026.09.26.754256v1
biorxiv.org
A draft atlas of the human plasma proteome at isoform resolution
Key plasma protein, including albumin, complement system proteins, and coagulation factors circulate in biochemically and functionally distinct isoforms, or proteoforms. Despite the importance of thes...
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Simon Bayly @simonbayly.bsky.social · 29/09/2026
Hmm, I have no clue how this patchy narrative is going to be turned into policy
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Katie Martin @katie0martin.ft.com · 29/09/2026
Either this is true, in which case *what are we doing here*? Shut it down. Or it's bullshit, in which case these are truly silly people unworthy of our money
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Simon Bayly @simonbayly.bsky.social · 28/09/2026
This was another wild race. Did MVDP go too early? Was Del Toro working for McNulty? Would Pog just have blown them all away? #cycling
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Simon Bayly @simonbayly.bsky.social · 28/09/2026
This was another wild race. Did MVDP go too early? Was Del Toro working for McNulty? Would Pog just have blown them all away? #cycling
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Carl Zimmer @carlzimmer.com · 27/09/2026
Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc
nyti.ms
Did Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)
An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.
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Simon Bayly @simonbayly.bsky.social · 26/09/2026
This was a phenomenal race
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Caroline Bartman @cbartman.bsky.social · 25/09/2026
Ok what is the most death metal biology term? Cytokine storm? Programmed death 1? Executioner caspase? Other?
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Simon Bayly @simonbayly.bsky.social · 25/09/2026
Most goth/emo would be The Golgi Complex
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Simon Bayly @simonbayly.bsky.social · 25/09/2026
Aberrant Splicing
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Simon Bayly @simonbayly.bsky.social · 24/09/2026
Biggest surprise I can remember was Tanaka and Fenn for electrospray MS. Most overlooked who still hasn’t won is Marvin Caruthers for phosphoamidite DNA synthesis
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Simon Bayly @simonbayly.bsky.social · 24/09/2026
New funds for UK life science venture firm www.british-business-bank.co.uk/news-and-eve... #biotech
british-business-bank.co.uk
Press release - 24 September, 2026 | British Business Bank
British Business Bank agrees to commit up to £135m to two new Advent Life Sciences funds
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The Francis Crick Institute @crick.ac.uk · 24/09/2026
Our next Medicine at the Crick event on 19 November explores 'not-so-acute' infections: viruses and bacteria that can persist in the body long after infection. Book online and in-person tickets ➡️ www.eventbrite.co.uk/e/medicine-a...
A person presents at a podium in front of an audience in an auditorium.
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Simon Bayly @simonbayly.bsky.social · 23/09/2026
Some of those that work forces are the same that wear black shortses
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Simon Bayly @simonbayly.bsky.social · 22/09/2026
174 km solo!
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Simon Bayly @simonbayly.bsky.social · 22/09/2026
Don’t you have a panier for your pain?
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Elodie Carmen Leroy @ecleroy.bsky.social · 21/09/2026
How can a single antibiotic halt translation across all domains of life? 🧬 Our new study in Nucleic Acids Research reveals how Sparsomycin traps active ribosomes through a conserved mechanism. academic.oup.com/nar/article/... #Ribosome #Translation #StructuralBiology #Antibiotics #RNA #iTPseq
Graphical representation of the T. thermophilus 70S ribosome showing the 30S and 50S subunits, mRNA, and P-site tRNA. Sparsomycin (yellow) binds in the peptidyl transferase center at the interface between the A and P sites. The enlarged view shows sparsomycin occupying the A-site cleft adjacent to the P-site fMet-tRNA, closely contacting its 3′ CCA end (C74, C75 and A76) and the attached fMet.
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Simon Bayly @simonbayly.bsky.social · 22/09/2026
"Share of revenue" = tax. And barely a squeak from the pharma companies. endpoints.news/pfizer-lilly...
endpoints.news
Pfizer, Lilly 'most favored nation' deals to give US share of revenue from raised foreign prices
Pfizer and Lilly's MFN contracts with HHS show the drugmakers agreed to share revenue from higher overseas prices with the government.
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
I works about 5 mins walk from here!
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
ALT text “pink protein slides towards and then aggressively hugs smaller teal protein”
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
Me too
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
RNA clumps together if you don't design it correctly www.pnas.org/doi/10.1073/...
pnas.org
Maintaining transcriptome solubility constrains mRNA sequence composition | PNAS
RNA is built from a four-nucleotide alphabet. Complementary sequences inevitably arise, creating pervasive opportunities for promiscuous RNA–RNA in...
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
🤣
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
The (Steric) Clash #chemsky #chemcaht
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
The Ramanes!
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
ALT text “pink protein slides towards and then aggressively hugs smaller teal protein”
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Simon Bayly @simonbayly.bsky.social · 19/09/2026
Very enjoyable (and very long) thread. Who knew there were so many restaurant related faux pas!
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Simon Bayly @simonbayly.bsky.social · 19/09/2026
I’m in two minds about this…
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Simon Bayly @simonbayly.bsky.social · 19/09/2026
Would this be at a Crab Museum by any chance?
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Simon Bayly @simonbayly.bsky.social · 19/09/2026
I’m in two minds about this…
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