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Shihui Chen

@shihuichen.bsky.social
68 followers 122 following 7 posts

Postdoc in @zernickagoetz.bsky.social’s Lab at Caltech | PhD in @cphil.bsky.social's lab at USC | Mammalian early embryo development, cell fate specification, ZGA

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Shihui Chen @shihuichen.bsky.social · 14/08/2026
Very excited to share that I’ve been awarded a Damon Runyon Postdoctoral Research Fellowship 🎉 This fellowship will provide four years of support for my postdoc research on mammalian cell fate specification. www.damonrunyon.org/discovery/da...
damonrunyon.org
Damon Runyon Cancer Research Foundation awards $4.2 million to exceptional early-career scientists | New Discoveries
The Damon Runyon Cancer Research Foundation has named 14 new Damon Runyon Fellows, brilliant postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading s...
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Nature Biotechnology @natbiotech.nature.com · 01/06/2026
Decoding the origins of cellular self-organization for engineered biology - @qichen-lab.bsky.social @zernickagoetz.bsky.social go.nature.com/4e1m3Br
go.nature.com
Decoding the origins of cellular self-organization for engineered biology - Nature Biotechnology
This Perspective positions cellular self-organization as a foundational principle for the origin of multicellular life and discusses how decoding this concept with stem cell-based models will advance ...
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RNA Society Journal @rnajournal.bsky.social · 08/01/2026
AGO–small RNA loading specificity arises from the integration of structural and biochemical features together with the spatiotemporal co-localization of small RNAs and their Argonaute partners bit.ly/48TOrnW
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Shihui Chen @shihuichen.bsky.social · 17/12/2025
New review out! 🧬🪱 How do Argonautes bind the right small RNAs? We synthesize how small RNA features, Argonaute properties, chaperones, and subcellular organization shape small RNA binding specificity. rnajournal.cshlp.org/content/earl...
rnajournal.cshlp.org
Decoding Argonaute Specificity: Insights from C. elegans and Beyond
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
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Abby Buchwalter @abbybuch.bsky.social · 22/07/2025
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
nature.com
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
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Raquel Fueyo @fueyoraquel.bsky.social · 12/05/2025
I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...
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Jessica Bloom @jessicarbloom.bsky.social · 03/07/2025
Our recent study exploring the mechanisms behind hybrid incompatibility in Caenorhabditis Elegans nematodes is now available at @currentbiology.bsky.social! Many thanks to my collaborators at UCSD - @odlab.bsky.social @greenbeegreen.bsky.social and the Rifkin Lab! www.cell.com/current-biol...
cell.com
Hybrid incompatibility emerges at the one-cell stage in interspecies Caenorhabditis embryos
Bloom et al. show that hybrid incompatibility between Caenorhabditis elegans group nematode species pairs arises immediately after fertilization, before zygotic gene expression. Primary defects in spe...
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Juliane Glaser @julianeg.bsky.social · 09/07/2025
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
nature.com
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
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Tugce Aktas @aktast.bsky.social · 30/06/2025
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. www.nature.com/articles/s41...
nature.com
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
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Henri Niskanen @henriniskanen.bsky.social · 04/06/2025
What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com ‬ with @yaotianzhang.bsky.social Denes Hnisz & team.
nature.com
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