iiinova — where your digital self keeps evolving

Reposted by Henri Niskanen

Aydan Bulut-Karslioglu @bulutkarslioglu.bsky.social · 03/05/2026

Very excited to share our newest findings! A very long team effort pursued by multiple team members -to frantically reproduce everything over and over-, we show mTOR-Polycomb synergy at promoters of developmental master regulator TFs in ESCs prior to their expression. www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by Henri Niskanen

Daniel MK Lee @dannimklee.bsky.social · 24/04/2026

New Preprint alert!🚨 Super excited to share my postdoc work now on BioRxiv. How does PRC2 loss lead to developmental failures? We combined rapid protein degradation with TLS embryoid models to uncover temporal and lineage-specific dependencies 🧬. Preprint: doi.org/10.64898/2026.04.18.719361

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Reposted by Henri Niskanen

Tugce Aktas @aktast.bsky.social · 25/02/2026

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.

doi.org

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Reposted by Henri Niskanen

Michał Małszycki @malszycki.bsky.social · 25/02/2026

I’m thrilled to share that my PhD work has been just published in Cell. After a long and bumpy ride, we uncovered the core function of nuclear speckles -splicing of GC-levelled exons- and traced the evolution of this gene architecture and condensates themselves to amniotes.

Graphical abstract: Speckle-proximal and speckle-dependent RNA has short introns, and simultaneous emergence of multiple exons requires heightened concentration of spliceosome components.
Speckle-independent RNA has long introns and can be spliced well with or without speckles
Speckle dependent introns evolved in amniotes. The reduction in intron length was accompanied by the increase of the intronic GC content, giving rise to GC-levelled intronic architecture. This exon-intron architecture is not present outside of amniotes (Fish, Invertebrates), and these organisms lack nuclear speckles.

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Reposted by Henri Niskanen

Aydan Bulut-Karslioglu @bulutkarslioglu.bsky.social · 23/06/2025

⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.

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Reposted by Henri Niskanen

Akis (Argyris) Papantonis @akispapantonis.bsky.social · 19/06/2025

This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u A short thread follows 1/n

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Reposted by Henri Niskanen

Max Planck Institute for Molecular Genetics @molgen.mpg.de · 06/06/2025

Work is a collaboration with @matthewkraushar.bsky.social, @aktast.bsky.social and the MPIMG Service Groups FACS, microscopy, sequencing and mass spec, as well as researchers from Austria, the US and Switzerland. Link to the publication: www.nature.com/articles/s41...

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Reposted by Henri Niskanen

Max Planck Institute for Molecular Genetics @molgen.mpg.de · 06/06/2025

In @nature.com Yaotian Zhang and @henriniskanen.bsky.social from the Hnisz Lab discovered a micropeptide, the "Killswitch," which alters the physical state of biomolecules in condensates. This tool solidifies dynamic, liquid-like droplets, affecting their function. --> www.molgen.mpg.de/4884827

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Reposted by Henri Niskanen

Sadaf Shadan @sshadan.bsky.social · 05/06/2025

A bottleneck for studying the biological function of biomolecular condensates is unavailability of tools to selectively probe them within living cells. @nature, researchers report one such tool, showcasing its use in various contexts including disease. www.nature.com/articles/s41...

nature.com

Probing condensate microenvironments with a micropeptide killswitch - Nature

Targeting a non-natural micropeptide ‘killswitch’ to several biomolecular condensates altered condensate compositions and revealed condensate functions in human cells

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Henri Niskanen @henriniskanen.bsky.social · 04/06/2025

What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com ‬ with @yaotianzhang.bsky.social Denes Hnisz & team.

nature.com

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