iiinova — where your digital self keeps evolving

Serge McGraw @sergemcgraw.bsky.social · 20/04/2026

Congrats @sproullab.bsky.social et al! Nice to see this one published in the final version!!! Love the 🧵!

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Duncan Sproul @sproullab.bsky.social · 10/04/2026

Very pleased to say that the paper version of our study examining the role of de novo DNMTs in cancer-associated hypomethylation is now out in @plos.org Genetics 🎉: doi.org/10.1371/jour... You can read more on the previous thread but here is a summary of the main updates! #epigenetics 🧵 1/9

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Serge McGraw @sergemcgraw.bsky.social · 02/02/2026

🚨 New preprint alert! DNMT1 is often elevated in cancer, but its direct impact on DNA methylation regulation has been hard to isolate in tumours full of confounding processes. Using a clean genetic system in mESCs, we asked: What does excess DNMT1 by itself do to the methylome? Let’s dive in 🧵 1/9

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Duncan Sproul @sproullab.bsky.social · 09/02/2026

Now had a chance to read through this pre-print. Interesting and unexpected findings! Increasing DNMT1 expression leads to remodelling of the methylome in mouse ES cells including gains and losses 😮 🧵 1/2 #epigenetics

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John Greally @greally.bsky.social · 05/02/2026

Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine. faculty-einstein.icims.com/jobs/17847/a...

faculty-einstein.icims.com

Albert Einstein College of Medicine | Medical Education | Biomedical Research

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Serge McGraw @sergemcgraw.bsky.social · 02/02/2026

If you're interested in DNA methylation dynamics, DNMT biology, disease modeling or epigenetic therapy, we hope this work sparks new ideas! 💡 Happy to discuss, critique, or collaborate! 9/9

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Serge McGraw @sergemcgraw.bsky.social · 02/02/2026

Together, our findings reveal that DNMT1 overexpression alone is sufficient to generate cancer-like DNA methylation patterns and highlight candidate underlying mechanisms that warrant deeper exploration. 8/9

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Serge McGraw @sergemcgraw.bsky.social · 02/02/2026

Conserved promoter hypermethylation between mESCs and human cancers showed signs of epigenetic priming and had sex-specific effects. 7/9

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Serge McGraw @sergemcgraw.bsky.social · 02/02/2026

The same promoter regions hypermethylated by DNMT1 overexpression in mESCs are also hypermethylated in various human cancers — demonstrating the biological relevance and translational potential of this model. 6/9

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Serge McGraw @sergemcgraw.bsky.social · 02/02/2026

DNMT1-targeted cancer therapies may have limits: some hypermethylation in mESCs resisted erasure following acute DNMT1 depletion. 5/9

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Serge McGraw @sergemcgraw.bsky.social · 02/02/2026

We also found increased CpG‑to‑CpG methylation variability, a feature associated with epigenetic instability in cancer. DNMT1 excess didn’t just shift DNA methylation levels — it disrupted DNA methylation precision. 4/9

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Serge McGraw @sergemcgraw.bsky.social · 02/02/2026

Despite global hypomethylation, we observed focal hypermethylation at promoters and CpG islands — another hallmark of cancer methylomes. These promoter DMRs were linked to pathways that align with the vast pathological potential of DNMT1 overexpression. 3/9

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Serge McGraw @sergemcgraw.bsky.social · 02/02/2026

Despite DNMT1 being a maintenance methyltransferase, overexpression led to global, widespread hypomethylation in mESCs, mirroring a paradox seen in cancer. 2/9

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Serge McGraw @sergemcgraw.bsky.social · 02/02/2026

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Serge McGraw @sergemcgraw.bsky.social · 28/01/2026

New work from the lab by @eli-elder.bsky.social !! Tread to follow shortly...

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Serge McGraw @sergemcgraw.bsky.social · 08/10/2025

The recruitment campaign is on! We’re seeking outstanding MSc, PhD, and Postdoctoral candidates to join @cra-chusj.bsky.social . If you’re passionate about epigenetics, development, and neurodevelopment, consider exploring the opportunities available in my lab. event.fourwaves.com/campagnerecr...

event.fourwaves.com

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Tom Hollenstein @tomhollenstein.bsky.social · 05/06/2025

My Canadian university, Queen's, is offering TWENTY 4-year funded PhDs (40k CAD/yr) for a student of ANY citizenship who has been accepted at a top 100 US university but have had offer rescinded OR are reconsidering offer due to US policy. Details found here👇 www.queensu.ca/grad-postdoc...

queensu.ca

Queen’s Special U.S. Doctoral Recruitment Initiative | School of Graduate Studies and Postdoctoral AffairsDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown...

Queen’s University is a globally engaged, research-intensive institution dedicated to attracting and supporting exceptional PhD students who will significantly advance our research mission.

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Serge McGraw @sergemcgraw.bsky.social · 14/05/2025

Congrats to all winners! ...but especially to own, Michelle Robb, for the Best Poster Award at #DOHaDCanada2025! Michelle presented our recent advances on Early Embryonic Alcohol Exposure ! 🏆

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Serge McGraw @sergemcgraw.bsky.social · 14/05/2025

Thank you, #DOHaDCanada2025, for organizing and for the invitation to present our work on Early Embryonic Prenatal Alcohol Exposure! #FASD #DOHaD #communautéFRQ

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DOHaD Canada @dohadcanada.bsky.social · 13/05/2025

Congratulations to our co-president, Dr. Kristin Connor (@kconnor.bsky.social), for being awarded the Nick Hales Award by the International DOHaD Society. #DOHaD2025

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ME Torres-Padilla @metorrespadilla.bsky.social · 21/04/2025

Paper Out👇🥳 thanks to ALL authors, Nakatani-san @tamas-schauer.bsky.social @palmrinmoy.bsky.social and bluesky-less RIF1 regulates Replication Timing in mouse embryos & (suprising) findings disentangling effects on transcription and LADs...lots to think about 🙄👍🤔 👉 www.cell.com/developmenta...

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Centre de recherche du CHUM @crchum.bsky.social · 10/04/2025

Sophie Petropoulos, chercheuse au CRCHUM, et son équipe révèlent pour la première fois que l’embryon préimplantatoire de cochon d’Inde est très similaire à l’embryon humain, ce qui ouvre la voie à une meilleure compréhension de l’infertilité et du développement humain précoce.

bit.ly

Le cochon d’Inde : un modèle animal prometteur pour l’étude de l’embryon humain

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Gareth Lim @glim2016.bsky.social · 13/04/2025

The Lim Lab at the @crchum.bsky.social is recruiting PhD students or Postdoctoral Fellows to study the roles of 14-3-3zeta in #adipocytes or pancreatic #betacells. Projects are supported by CIHR, NSERC, or Diabetes Canada. Please share with people who might be interested! Thanks!

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Esther Verheyen 🇨🇦 @estherverheyen.bsky.social · 12/04/2025

I urge folks to sign this letter and share it with their university colleagues to get critical mass.

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Pablo Nepomnaschy @pablonep.bsky.social · 08/04/2025

Dear USA colleagues, paradoxically the environment is warmer for doing science north of the border.♥️

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Drug Monkey @drugmonkey.bsky.social · 04/04/2025

This should save grant reviewers a lot of time on some of those proposals…..

Just because you are unique doesn’t mean you are useful over a picture of a wooden headed axe.

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Petr Svoboda @svobodalab.bsky.social · 04/04/2025

Argonautes 2025 will cover progress in: Structural insights Effector complexes: formation, composition & function Post-transcriptional silencing Transcriptional silencing & DNA cleavage Post-translational modifications and regulations Medical aspects 27-30/8/2025 argonautes.img.cas.cz Pls RT!

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Jim Woodgett @jwoodgett.bsky.social · 03/04/2025

For Canadian cancer researchers concerned about travelling to the US (🙋🏼‍♂️), please check out and plan to be at the Canadian Cancer Research Conference in Calgary this November. All welcome. www.ccra-acrc.ca/conference/

ccra-acrc.ca

Conference - CCRA

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Anja Groth @groth-anja.bsky.social · 28/03/2025

A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.

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Ben Martin @benjaminmartin.bsky.social · 27/03/2025

Come by my colleague!! Assistant professor position in molecular neurobiology at @mcgill.ca and the Lady Davis Institute! mcgill.wd3.myworkdayjobs.com/McGill_Caree... Montreal is an amazing city and the Lady Davis is a great institute to work at!

mcgill.wd3.myworkdayjobs.com

Assistant Professor (Research), Department of Anatomy and Cell Biology (C1-250306)

Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

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Epigenetics at Helmholtz Munich @epihmgu.bsky.social · 25/03/2025

🌟 SAVE THE DATE: Talent Forum 2025! 🗓️ November 18–19 📍 @www.helmholtz-munich.de‬, Germany Showcase your research and network with global talents in #Epigenetics & Nucleic Acids Research! Apply by July 31 for a speaker spot —travel & accommodation covered. 🔜 Website coming soon!

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The Allard lab @allard-lab-ucla.bsky.social · 24/03/2025

📣 Tenure track job alert! Assistant and associate tenure-track position at McGill University in toxicology and/or pharmacology. I know the department very well and could not speak more highly of the supportive environment it provides and of its leadership! www.nature.com/naturecareer...

nature.com

Assistant / Associate Professor (Tenure Track), Department of Pharmacology and Therapeutics - Montréal, Quebec (CA) job with McGill University | 12837963

Faculty of Medicine and Health Sciences – Department of Pharmacology and Therapeutics, Toxicology (L000054

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Esther Verheyen 🇨🇦 @estherverheyen.bsky.social · 22/03/2025

Now seems like a great time to share a starter pack I made when I joined BlueSky! Let me know if you'd like to be added: go.bsky.app/6aMSMpy

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Sarah Goetz @sarahgoetz.bsky.social · 15/03/2025

This. But also we are up against the fact that academic scientists in particular are often unprepared to think of ourselves as workers, build solidarity, and take collective action. This moment is going to require a really big pivot!

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Carol Chen @carolchen.bsky.social · 04/03/2025

My alma mater, the University of British Columbia, Dept of Medical Genetics, is hiring for a tenure track junior faculty position specializing in chromatin regulation / gene regulatory mechanisms. Beautiful city and vibrant epigenetics research. Please share! medgen.med.ubc.ca/assistant-pr...

medgen.med.ubc.ca

Assistant Professor (Tenure-Track) | Department of Medical Genetics | Life Sciences Institute (LSI) - Department of Medical Genetics

The Department of Medical Genetics, in collaboration with the Life Sciences Institute (LSI), invites applications for a full-time faculty position at the rank of Assistant Professor, tenure track with...

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Serge McGraw @sergemcgraw.bsky.social · 01/03/2025

Indeed! Most were transient or did not show major alterations in expression, but some became or remained upregulated. We are following some of those to better understand how they might lead to chimeric gene transcripts, and how these could be further impacted during differentiation.

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