iiinova — where your digital self keeps evolving

Reposted by Elizabeth Elder

Duncan Sproul @sproullab.bsky.social · 10/04/2026

Very pleased to say that the paper version of our study examining the role of de novo DNMTs in cancer-associated hypomethylation is now out in @plos.org Genetics 🎉: doi.org/10.1371/jour... You can read more on the previous thread but here is a summary of the main updates! #epigenetics 🧵 1/9

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Reposted by Elizabeth Elder

Duncan Sproul @sproullab.bsky.social · 09/02/2026

Now had a chance to read through this pre-print. Interesting and unexpected findings! Increasing DNMT1 expression leads to remodelling of the methylome in mouse ES cells including gains and losses 😮 🧵 1/2 #epigenetics

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Reposted by Elizabeth Elder

Serge McGraw @sergemcgraw.bsky.social · 02/02/2026

🚨 New preprint alert! DNMT1 is often elevated in cancer, but its direct impact on DNA methylation regulation has been hard to isolate in tumours full of confounding processes. Using a clean genetic system in mESCs, we asked: What does excess DNMT1 by itself do to the methylome? Let’s dive in 🧵 1/9

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Reposted by Elizabeth Elder

Serge McGraw @sergemcgraw.bsky.social · 28/01/2026

New work from the lab by @eli-elder.bsky.social !! Tread to follow shortly...

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