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Sdelci Lab

@sdelcilab.bsky.social
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The Epigenetic Face of Cancer Metabolism Lab We study NUCLEAR METABOLISM at CRG, Barcelona sdelcilab.crg.eu

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Sdelci Lab @sdelcilab.bsky.social · 21/04/2026
This changes how we think about metabolism-epigenetics coupling. Congrats to first author Toni Gañez 🍾 @crg.eu @erc.europa.eu @cienciagob.bsky.social
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Sdelci Lab @sdelcilab.bsky.social · 21/04/2026
🧬 Phosphatidylinositol signaling (PIP2) dynamically rewires in the nucleus 🧪 This directly controls histone methylation (H4K20me1) 🔁 Linking metabolism → chromatin → cell cycle progression 👉 A new layer of regulation: nuclear lipid metabolism as a driver of chromatin state
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Sdelci Lab @sdelcilab.bsky.social · 21/04/2026
🚨 New paper out! We show that nuclear metabolism is NOT static, it oscillates with the cell cycle. 🔗 advanced.onlinelibrary.wiley.com/doi/10.1002/... #epigenetics #metabolism #cellcycle #chromatin
advanced.onlinelibrary.wiley.com
Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase-specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol me...
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Sdelci Lab @sdelcilab.bsky.social · 06/03/2026
Thanks a lot! We would be happy to explore it together 🤩
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Sdelci Lab @sdelcilab.bsky.social · 06/03/2026
Huge work led by Savvas Kourtis, supported by the @erc.europa.eu and @crg.eu
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Sdelci Lab @sdelcilab.bsky.social · 06/03/2026
Why are they there? Do they locally generate metabolites to regulate chromatin? Could they become new drug targets or disease biomarkers? These findings highlight how subcellular localization and moonlighting functions can reshape how we think about metabolism.
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Sdelci Lab @sdelcilab.bsky.social · 06/03/2026
New paper out in Nature Communications: www.nature.com/articles/s41... We found >250 metabolic enzymes on chromatin. Only ~20 had been reported before. This means hundreds of metabolic enzymes may have unexplored nuclear roles.
nature.com
Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues - Nature Communications
Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non...
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Sdelci Lab @sdelcilab.bsky.social · 27/02/2026
Thanks a lot for the invitation! It was great fun to be there 😊🤩
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Sdelci Lab @sdelcilab.bsky.social · 24/12/2025
And then our first PhD student wins the award for Best Thesis of the Year… a wonderful Christmas present 🎄✨ It really makes us feel we’re doing things the right way. Congratulations, Dr. Natalia Pardo Lorente, so well deserved 👏🎓 @crg.eu @upf.edu @prbb.org
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Centre de Regulació Genòmica (CRG) @crg.eu · 03/12/2025
Big congrats to Sara Sdelci @sdelcilab.bsky.social for being as one of the 2025 @embo.org Young Investigators (YIPs), joining 28 outstanding early-career scientists recognised for excellence and originality in the life sciences. She is the eighth CRG scientist to join the prestigious programme!
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Sdelci Lab @sdelcilab.bsky.social · 02/12/2025
I am (Sara Sdelci, @crg.eu) very happy to have been selected as an @embo.org YIP! Thank you for selecting our project on how nuclear metabolism shapes cellular proliferation and aging; we are truly excited for the beautiful science ahead!
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Sdelci Lab @sdelcilab.bsky.social · 10/10/2025
We did it in cancer cell lines and validated the phenotype in cancer tissues
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Sdelci Lab @sdelcilab.bsky.social · 10/10/2025
Not IN, they are compressing the nucleus from the outside ;)
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Sdelci Lab @sdelcilab.bsky.social · 10/10/2025
Earlier this summer we have published this. Looks like a similar localization of mitochondria in the centre of the nucleus: www.nature.com/articles/s41...
nature.com
Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects - Nature Communications
The authors uncover a mechano-metabolic adaptation where confinement induces rapid mitochondrial relocalization to the nuclear periphery, generating localized nuclear ATP surges that support chromatin remodeling, DNA repair, and cell cycle progression.
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Sdelci Lab @sdelcilab.bsky.social · 01/10/2025
Dr. Jane Goodall has passed away. Her groundbreaking work with chimpanzees and her lifelong dedication to conservation changed how we see and care for our planet.
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Arnau Sebé-Pedrós @arnausebe.bsky.social · 24/09/2025
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...
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Wolfgang Huber @wkhuber.bsky.social · 16/09/2025
Science: only when you write up the manuscript, you realize what you should have done.
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Sdelci Lab @sdelcilab.bsky.social · 07/09/2025
Being open to new ideas: Metabolic Enzymes in the Nucleus as Chromatin Instructors? Merging #chromatin #epigenetics #metabolism To understand new cellular rules.
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Sdelci Lab @sdelcilab.bsky.social · 30/07/2025
Uncovering how mechanical forces can influence nuclear ATP levels, with downstream effects on DNA damage response and cell cycle progression. #Mechanobiology #NuclearMetabolism #CellFate #DNArepair #CellCycle
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Sdelci Lab @sdelcilab.bsky.social · 30/07/2025
🚀 We’re excited to share our latest publication in collaboration with Verena Ruprecht's group at @crg.eu Mechanobiology meets Nuclear Metabolism www.nature.com/articles/s41...
nature.com
Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects - Nature Communications
The authors uncover a mechano-metabolic adaptation where confinement induces rapid mitochondrial relocalization to the nuclear periphery, generating localized nuclear ATP surges that support chromatin...
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Sdelci Lab @sdelcilab.bsky.social · 30/05/2025
Fantastic to see this wonderful piece out! Happy to have contributed to this effort 💪
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Sandra Castillo @sandradcastillo.bsky.social · 18/12/2024
🔬 ¡Buscamos Técnico/a de laboratorio! 📋 Mantenimiento de colonia, procesamiento de muestras y más. 📍 Barcelona 📩+info: hospitalsantjoandedeu.talentclue.com/es/node/1129... Please RT!
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
BIG THANKS to everyone involved, especially Toni for his amazing work! Thanks to our sponsors: @ageinves.bsky.social @ERC_Research #ERCStG EPICAMENTE @crg.eu
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
Open questions: Is nuclear metabolism linked to #aging? Can we reverse the aging process by restoring nuclear metabolism? What else besides PIP2? If you are interested in answering these questions, please contact us!
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
Our study links nuclear PIP2 metabolism to nucleoli structure, histone modification, and cell cycle progression. This provides evidence that nuclear metabolism oscillations can control cell cycle progression, which, when altered, can induce cell cycle arrest and cell senescence.
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
4) The aberrant localization of PIP2 in the nucleus/nucleoli and the alteration of the nucleoli structure lead to changes in the accumulation of histone marks. For example, H4K20me1 decreases, which subsequently affects proper cell cycle progression.
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
3) What happens to cells when we interfere with PIP2 metabolism in the nucleus? In addition to preventing cell cycle progression, the structure of the nucleolus is affected and the localization of PIP2 to the Fibrillarin-labeled nucleoli region is altered.
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
2) We used our lab's gold standard chromatome protocol to study the oscillation of metabolic enzymes on chromatin during the cell cycle. We identified a correlation between cell cycle progression and PIP2 metabolism on chromatin.
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
1) By integrating FUCCI reporters and classical proliferation/senescent markers, we identified a population of cells, which we termed G0-senescent, that had never before been identified using FUCCI.
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
Our initial question was: does the cell cycle control the association of metabolic enzymes with chromatin? The short answer is YES! We adapted the FUCCI system and extensively characterized U2OS FUCCI using HT-microscopy and FACS.
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
As promised, here is our NEW preprint on CELL CYCLE ASSOCIATED PIP2 NUCLEAR METABOLISM by our SUPER postdoc Toni Gañez, who knows all the secrets of FUCCI reporters 👇 www.biorxiv.org/content/10.1...
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
Open questions: Is nuclear metabolism linked to aging? Can we reverse the aging process by restoring nuclear metabolism? What else besides PIP2? If you are interested in answering these questions, please contact us!
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
Our study links nuclear PIP2 metabolism to nucleoli structure, histone modification, and cell cycle progression. This provides evidence that nuclear metabolism oscillations can control cell cycle progression, which, when altered, can induce cell cycle arrest and cell senescence.
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
4) The aberrant localization of PIP2 in the nucleus/nucleoli and the alteration of the nucleoli structure lead to changes in the accumulation of histone marks. For example, H4K20me1 decreases, which subsequently affects proper cell cycle progression.
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
3) What happens to cells when we interfere with PIP2 metabolism in the nucleus? In addition to preventing cell cycle progression, the structure of the nucleolus is affected and the localization of PIP2 to the Fibrillarin-labeled nucleoli region is altered.
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
2) We used our lab's gold standard chromatome protocol to study the oscillation of metabolic enzymes on chromatin during the cell cycle. We identified a correlation between cell cycle progression and PIP2 metabolism on chromatin.
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
We adapted the FUCCI system and extensively characterized U2OS FUCCI using microscopy and FACS. 1) By integrating FUCCI reporters and classical proliferation/senescent markers, we identified a population of cells, which we termed G0-senescent, that had never before been identified using FUCCI.
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Sdelci Lab @sdelcilab.bsky.social · 03/01/2025
Our initial question was: does the cell cycle control the association of metabolic enzymes with chromatin? The short answer is YES!
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Sdelci Lab @sdelcilab.bsky.social · 24/12/2024
Merry Christmas from the Sdelci Lab! Stay tuned for our last preprint before the end of the year... lots of FUCCI colors 🎄-style and metabolic enzymes on chromatin during cell cycle progression COMING SOON 💥
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NUCLEAR-DN @nucleardn.bsky.social · 19/12/2024
🚀 The NUCLEAR Project website is live! 🌟 Explore how metabolism regulates genome function & cell identity. 💡 Cutting-edge research, interdisciplinary training, & international collaboration. 🌍 Learn more: nuclear-dn.eu #MarieCurieActions #PhD
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NUCLEAR-DN @nucleardn.bsky.social · 19/12/2024
🚨 16 PhD positions open in early 2025! 🚀 Join NUCLEAR for cutting-edge research on nuclear metabolism, cell identity, and genome function. 🌍 Details on projects, eligibility & applications coming soon.Stay tuned! #PhDOpportunities#MarieCurieActions 👉http://nuclear-dn.eu
NUCLEAR
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Sdelci Lab @sdelcilab.bsky.social · 20/12/2024
Looking for a PhD position? We have 16 available in our NUCLEAR Horizon MCSA Doctoral Network. Don't miss the opportunity! nuclear-dn.eu/2024/12/18/1...
nuclear-dn.eu
16 Doctoral Candidate Positions Opening Soon | Nuclear DN
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Sdelci Lab @sdelcilab.bsky.social · 17/12/2024
We made it among the BEST PICTURES OF THE YEAR by @natureportfolio.bsky.social www.nature.com/immersive/d4... Beautiful image representing in red the nuclear localization of MTHFD2 in pluripotent colon organoids by @NataliaPardoL Find the manuscript here: www.nature.com/articles/s41...
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Sdelci Lab @sdelcilab.bsky.social · 11/12/2024
Thanks to @bpodaily.bsky.social for choosing our beautiful colon organoid as a picture of the day. MTHFD2 in the nucleus in red: bpod.org.uk
bpod.org.uk
BPoD | Metabolic Side Hustle
BPoD (Biomedical Picture of the Day) is a free educational resource showcasing biomedical imagery. Managed by the MRC Laboratory of Medical Sciences the website aims to engage the general public. Imag...
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Centre de Regulació Genòmica (CRG) @crg.eu · 28/11/2024
Our amazing CRG PhD community are celebrating their annual symposium today and tomorrow. Follow our first year students on Bluesky for snippets about all the amazing talks featured this year: @lassemiddendorf.bsky.social @mattezambon.bsky.social @iseultleahy.bsky.social
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Sdelci Lab @sdelcilab.bsky.social · 28/11/2024
Wooow thank you, such a nice job!
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georgia 🏴󠁧󠁢󠁷󠁬󠁳󠁿 @blahttodea.bsky.social · 11/11/2024
hey everyone! i made a list of some useful starter packs (primarily biology/earth sciences with a few bonus things thrown in) to share with friends who have joined bsky in the last week and thought it may be useful for some people here too! 🌍🧪 #SciSky #BioSky docs.google.com/document/d/1...
docs.google.com
Starter packs
BIOLOGY Ecology Macroecology https://go.bsky.app/GBn9pNZ Global ecology https://go.bsky.app/V6tN4cv Trait based ecology and evolution https://go.bsky.app/PThMXeX Invasion biology https://go.b...
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Christian Frezza @frezzalab.bsky.social · 27/11/2024
I have curated a second "metabolism" starter pack, as the first quickly got full. Please have a look, and I am happy to add others (sorry for those who may appear in both): go.bsky.app/CH1MctZ
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Sdelci Lab @sdelcilab.bsky.social · 26/11/2024
Thank you.
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Sdelci Lab @sdelcilab.bsky.social · 25/11/2024
Amazing opportunity to join a great group.
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