Reposted by Sarah GoreyNEJM.org @nejm.org · 03/10/2025For a student with strep throat and an unconfirmed penicillin allergy, would you prescribe a nonpenicillin antibiotic or give penicillin under doctor supervision? Read the case vignette and essays on both treatment options and cast your vote: nej.md/48eHjm9 #MedSky #MedEd 042
Reposted by Sarah GoreyCORE IM @coreimpodcast.bsky.social · 01/10/20251/ 🚨 NEW #BeyondJournalClub w/ @NEJMGroup: The Bolland study Question: Does infrequent zoledronate therapy in patients without osteoporosis prevent fractures? Answer: ⤵️ www.coreimpodcast.com/2025/10/01/b... 163
Sarah Gorey @sarahgorey.bsky.social · 04/09/2025Well done @cpkotanidis.bsky.social ! Also check out our manuscript in @annalsofim.bsky.social url.us.m.mimecastprotect.com/s/kNYpCDkAO2...url.us.m.mimecastprotect.comACP Journals 021
Reposted by Sarah GoreyPeer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 04/09/20252.2.1 In an RCT comparing 'uselessly elongated' vs shorter #PeerReview of @neuripsconf.bsky.social 2022 submissions, the longer reviews received higher quality scores, suggesting a length bias among reviewers, w implications for #LLM-generated reviews journals.plos.org/pl... @scsatcmu.bsky.social 093
Reposted by Sarah GoreyPeer Review Congress #PRC11 Coming 2029! @peerreviewcongress.bsky.social · 04/09/2025In the med literature, statements like “to our knowledge [TOK], this is the FIRST...” often replace a proper systematic search. Among 4488 PMC articles in 6 leading medical journals published 2020-2024, TOK prevalence was 21.7%, w @PLOSMedicine highest (48.4%) and @NEJM lowest (1.3%) #CornellVet 173
Reposted by Sarah GoreyChris Kotanidis @cpkotanidis.bsky.social · 31/07/2025The win ratio method is gaining traction in #RCTs. Is it just a trend or a smarter way to look at composite hierarchical outcomes? We break it down in our latest Stats, STAT!📊 in NEJM Evidence. youtube.com/watch?v=jKtF... #stats @nejm.org @sarahgorey.bsky.social @chardin.bsky.social @ai.nejm.orgyoutube.comHow Win Ratios Work | NEJM EvidenceYouTube video by NEJM Group 4154
Reposted by Sarah GoreyBlue Planet Society @blueplanetsociety.bsky.social · 02/06/2025Irish whale watching business closes after 25 years. 🐳 “There are only a few whales left - the water is overfished.” The owner was previously a commercial fisher but gave up when fish stocks crashed. “It wasn’t something I wanted to be a part of.” 🎣❌ www.irishtimes.com/ireland/2025...irishtimes.com‘It’s an empty, lifeless sea’: Whales leave Cork waters, putting watchers out of businessStocks of sprat have crashed, forcing whales away, says businessman whose livelihood has been ruined 23819
Reposted by Sarah GoreyNEJM.org @nejm.org · 19/05/2025In the BATURA trial, as-needed albuterol–budesonide resulted in a lower risk of severe asthma exacerbation than as-needed albuterol among participants with disease that was uncontrolled despite treatment for mild asthma. Full trial results: nej.md/43uVpwK #ATS2025 @atscommunity.bsky.social 0102
Reposted by Sarah GoreyNEJM.org @nejm.org · 21/05/2025BRIDGE-TNK trial: Among 550 patients with stroke due to large-vessel occlusion who had presented within 4.5 hours after onset, 90-day functional outcomes were better with intravenous tenecteplase before thrombectomy than with thrombectomy alone. nej.md/3GTVKAk #ESOC2025 @esostroke.bsky.social 0112
Sarah Gorey @sarahgorey.bsky.social · 06/05/2025Really enjoying @cpkotanidis.bsky.social’s fascinating presentation on his interesting work at @brighamandwomens.bsky.social on identifying risk markers of CVD in patients with IMIDs 🤩👏👏👏 131
Reposted by Sarah GoreyNEJM.org @nejm.org · 02/05/2025For a woman with device-detected atrial fibrillation, would you initiate anticoagulant therapy or recommend continuation of antiplatelet therapy? Read the case vignette and essays on both treatment options and cast your vote: nej.md/4lQzxTA #MedSky #CardioSky #Afib 396
Reposted by Sarah GoreyNEJM.org @nejm.org · 27/04/2025Both clonal hematopoiesis of indeterminate potential (CHIP) and cancer are more common with age. When they coexist in the same patient, CHIP cells may migrate to the tumor and have an adverse effect on overall survival. Full study results: nej.md/3EnzMVu #MedSky #Hematology 1239
Reposted by Sarah GoreyNEJM.org @nejm.org · 22/04/2025Our partnership with @glaucomflecken.bsky.social continues as he summarizes new research into fracture prevention with infrequent zoledronate in women 50 to 60 years of age. Access the article for free: nej.md/DrG15 #MedSky 02711
Reposted by Sarah GoreyNEJM.org @nejm.org · 22/04/2025A 56-year-old man was transferred to a burn center for management of pavement burns on his feet that had occurred during a heat wave. Read the full case details: nej.md/3Rh2XfR @uwsph.bsky.social #MedSky #ClimateChange 1132
Reposted by Sarah GoreyChris Kotanidis @cpkotanidis.bsky.social · 22/04/2025New research alert: Our latest report highlights a significant reduction in coronary #inflammation and residual inflammatory risk as captured by #CCTA imaging using CaRi-Heart AI in women with #BreastCancer 2 years post-RT #AI #CardioOncology #CardioEd #EHJ @escardio.bsky.socialacademic.oup.comCoronary inflammation and cardiovascular risk in breast cancer after radiotherapyRadiotherapy (RT) is known to reduce the rate of disease recurrence following breast-conserving surgery in patients with breast cancer, but also entails ir 023
Reposted by Sarah GoreyCORE IM @coreimpodcast.bsky.social · 16/04/20251/ 🚨 NEW #BeyondJournalClub w/ @NEJMGroup: PURPOSE Trials Both PURPOSE 1 & 2 used a new long acting medication: Lenacapavir! Let’s learn what we can takeaway from these trials ⤵️ 🖥️: coreimpodcast.com/2025/04/16/a-r… 142
Reposted by Sarah GoreyShreya P. Trivedi MD, MHPE @shreyatrivedimd.bsky.social · 02/04/2025An outstanding episode - learned a ton 🥂 022
Reposted by Sarah GoreyNEJM.org @nejm.org · 29/03/2025Editorial: Cancer-Associated Venous Thromboembolism — Beyond 6 Months nej.md/4iB6wcA 041
Reposted by Sarah GoreyChris Kotanidis @cpkotanidis.bsky.social · 26/03/2025Ever wondered how interim analyses work in #RCTs? 📊 Check out our Stats, STAT! video at NEJM Evidence: @nejm.org @ai.nejm.org @sarahgorey.bsky.social evidence.nejm.org/doi/full/10.... #MedStats #ClinicalTrialsevidence.nejm.orgHow Interim Analyses WorkThis Stats, STAT! animated video explores interim analyses in clinical trials. During these evaluations of the data, researchers may assess safety, efficacy, and verify sample size assumptions, but... 133
Reposted by Sarah GoreyNEJM.org @nejm.org · 18/03/2025What is the impact of microplastics on human health? The latest episode of Beyond Journal Club, a collaboration between @coreimpodcast.bsky.social and NEJM Group, takes a deep dive into the APAChE study on microplastics and cardiovascular disease. 🎧 Listen here: nej.md/4igpJQy #MedSky 22512
Reposted by Sarah GoreyNEJM.org @nejm.org · 14/03/2025The SCALE Kids trial, summarized here by NEJM Editorial Fellow Harleen Marwah, MD, assessed the efficacy and safety of liraglutide, as compared with placebo, as an adjunct treatment to lifestyle interventions, for the treatment of obesity in children 6 to 12 years of age. Full trial: nej.md/3MBP1uc 264
Sarah Gorey @sarahgorey.bsky.social · 05/03/2025A great listen from the coreIM team on potential health effects of microplastics and a nuanced discussion on causality and limitations of observational studies ❤️👏🐥 042
Reposted by Sarah GoreyIrish Doctors for the Environment @irishdocsenv.bsky.social · 25/02/2025A truly beautiful piece by Dr Lisa McNamee (@lisadangermcnamee.bsky.social)! Everyone should read this!medicalindependent.ieTurning despair into action - Medical IndependentIn January, climate action advocate and Dundalk GP Dr Seán Owens was seriously injured while cycling home from work... 1289
Reposted by Sarah GoreyThe Lancet @thelancet.com · 25/02/2025"By staying true to its mission and embracing necessary reforms, PEPFAR can...continue to be a beacon of hope in the fight against HIV/AIDS." Comment—PEPFAR under review: what's at stake for PEPFAR's future tinyurl.com/28ahdmv8 #MedSkytinyurl.comPEPFAR under review: what's at stake for PEPFAR's futureThe US President's Emergency Plan for AIDS Relief (PEPFAR) faces a pivotal moment, confronting one of its most challenging periods since its launch in 2003. The new policy priorities of the administra... 076
Reposted by Sarah GoreyNEJM.org @nejm.org · 25/02/2025How much training do you need to do to run a 5K? 🏃 The NEJM Evidence team aims to find out in this Stats, STAT! animated video on linear regression. Watch the full video: youtu.be/qUfVrYKetfA #MedSky #ScienceSky #Statistics 0167
Reposted by Sarah GoreyJAMA @jama.com · 18/02/2025"Without research to point toward a healthier country, there will be poorer national health and less capacity to do what people do...on either end of the political spectrum." Read the Editorial by JAMA Health Forum EIC Sandro Galea and JAMA EIC @kbibbinsdomingo.bsky.social. ja.ma/4b6Z2LJ #MedSky 111261
Reposted by Sarah GoreyNEJM.org @nejm.org · 12/02/2025Perspective by Eleanor R. Menzin, MD: With U.S. politics threatening to erase the gains of science, reduce access to vaccines, and undermine their vast public health benefit, what is a conscientious pediatrician to do? Read the full Perspective: nej.md/4iZNHQW 04723
Reposted by Sarah GoreyNEJM.org @nejm.org · 12/02/2025A 29yo man with well-controlled HIV infection presented with a 1-week history of a painful, whitish discoloration on his tongue. Smooth, pink, guttate macules were present on the tongue within a white coating. Full case from @aidshealthcare.bsky.social : nej.md/4jNuAdw #MedSky #IDSky 284
Reposted by Sarah GoreyThe Lancet @thelancet.com · 07/02/2025“...to care is an act not of weakness, but of strength.” The Lancet response: bit.ly/4jRb5Av 14627359
Reposted by Sarah GoreyNEJM.org @nejm.org · 05/02/2025Editorial: Medium- and Distal-Vessel Occlusion — The Limit of Thrombectomy? nej.md/40Hu9bP 022
Reposted by Sarah GoreyNEJM.org @nejm.org · 05/02/2025In the DISTAL trial involving 543 patients with stroke due to occlusion of medium or distal vessels, endovascular treatment within 24 hours after the onset of symptoms was not effective in improving functional outcome at 90 days. nej.md/4jYWV0z #ISC25 | @ahascience.bsky.socialnej.mdEndovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels | NEJMEndovascular treatment (EVT) of stroke with large-vessel occlusion is known to be safe and effective. The effect of EVT for occlusion of medium or distal vessels is unclear. We randomly assigned pa... 162
Reposted by Sarah GoreyNEJM.org @nejm.org · 05/02/2025In the ESCAPE-MeVO trial involving patients with ischemic stroke due to medium-vessel occlusion, thrombectomy within 12 hours did not lead to a better functional outcome and lower mortality at 90 days than usual care. Full trial results: nej.md/40LTUaL #ISC25 | @ahascience.bsky.socialnej.mdEndovascular Treatment of Stroke Due to Medium-Vessel Occlusion | NEJMWhether the large effect size of endovascular thrombectomy (EVT) for stroke due to large-vessel occlusion applies to stroke due to medium-vessel occlusion is unclear. In a multicenter, prospective,... 1106
Reposted by Sarah GoreyThe Irish Times @irishtimes.com · 04/02/2025Epilepsy: ‘It’s like having the sword of Damocles above your head’irishtimes.comEpilepsy: ‘It’s like having the sword of Damocles above your head’Former international cricketer Emma Beamish on living with the anxiety of never knowing when it might strike again, and her decision not to have children 041
Reposted by Sarah GoreyNEJM.org @nejm.org · 02/01/2025An 84-year-old man with benign prostatic hyperplasia who had been admitted to the hospital with acute kidney injury due to obstructive uropathy was noted to have gray skin. The skin changes had been present for 5 years. 1/3 #MedSky 1142
Reposted by Sarah GoreyNEJM.org @nejm.org · 03/01/2025From March through October 2024, a total of 46 human cases of highly pathogenic avian influenza A(H5N1) virus infections were identified in the United States, with 20 linked to poultry exposure and 25 to dairy cow exposure. Read the full article: nej.md/3VU4R8I #MedSky #IDSkynej.mdHighly Pathogenic Avian Influenza A(H5N1) Virus Infections in Humans | NEJMHighly pathogenic avian influenza A(H5N1) viruses have caused widespread infections in dairy cows and poultry in the United States, with sporadic human cases. We describe characteristics of human A... 13717
Reposted by Sarah GoreyCORE IM @coreimpodcast.bsky.social · 11/12/20241/ 🚨 NEW #BeyondJournalClub with @NEJMGroup: REVISE Trial Do PPIs reduce the risk of clinically important upper GI bleeding? ⤵️ 🖥️: coreimpodcast.com/2024/12/11/str… Sponsor: Freed AI 132
Sarah Gorey @sarahgorey.bsky.social · 10/12/2024@nejm.org is seeking submissions for images highlighting the health impact of climate change to be featured during Earth Month 2025. Info at nejm.org/event-info #MedSky #ClimateChange #EnvironmentalHealth 020
Reposted by Sarah GoreyKen Milne MD @thesgem.bsky.social · 27/11/2024This is a reminder that spurious correlations can be observed in observational studies. We should be skeptical of this type of data. Hypothesis generating. Proper RCTs should be performed if possible to conclude causation. www.tylervigen.com/spurious-cor... #MedSkytylervigen.comSpurious CorrelationsCorrelation is not causation: thousands of charts of real data showing actual correlations between ridiculous variables. 0123
Reposted by Sarah GoreyIrish Doctors for the Environment @irishdocsenv.bsky.social · 27/11/2024Irish people will die in significant numbers due to rising temperatures. Irish people will die in significant numbers due to rising temperatures, HSE specialist claims, yet #ClimateChange remains a peripheral issue of the #GE24.irishtimes.comIrish people will die in significant numbers due to rising temperatures, HSE specialist claimsHealthcare is at climate frontline, notably in emergency departments and at primary care level, conference hears 053
Sarah Gorey @sarahgorey.bsky.social · 22/11/2024The New England Journal of Medicine is inviting submissions for Images in Clinical Medicine on the theme of health impacts of climate. Deadline is 1 Jan! See nejm.org for details #climate #healthimpactofclimatechange #climateandhealth #climatecrisis 000