iiinova — where your digital self keeps evolving

Sanjay Srivatsan @sanjaysrivatsan.bsky.social · 11/08/2026

A new blog post thinking through the parallels between protein structure prediction and virtual cell efforts. Many of our current approaches to collect data to build a virtual cell model lack the abstraction that links measurement and function. t.co/4sPSMaLWLL

Acknowledgement: Illustration by David S. Goodsell, RCSB Protein Data Bank and the Scripps Research Institute. doi: 10.2210/rcsb_pdb/goodsell-gallery-050

Kinetochores separate chromosomes when eukaryotic cells divide. This illustration shows a yeast kinetochore (green) attached to a disassembling microtubule (blue). Chromatin is shown at upper right with DNA in yellow and histones in orange.

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Reposted by Sanjay Srivatsan

Sriram Pendyala @treependyala.bsky.social · 07/07/2025

🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇 1/9

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Reposted by Sanjay Srivatsan

Chiraag Kapadia @chiraagkapadia.bsky.social · 06/03/2025

Delighted to share my PhD thesis work is now published in @nature.com! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynmics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis www.nature.com/articles/s41...

nature.com

Clonal dynamics and somatic evolution of haematopoiesis in mouse - Nature

Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using labo...

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Reposted by Sanjay Srivatsan

Sri Kosuri @srikosuri.bsky.social · 08/02/2025

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

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Sanjay Srivatsan @sanjaysrivatsan.bsky.social · 19/12/2024

We need more programs like this one to bring fresh perspectives into the biological sciences. As highlighted in the fellowship link, our lab is excited to co-advise fellows eager to tackle the world’s biggest challenges using cutting-edge tools. Feel free to DM me if you’d like to talk!

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