FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosyst...

A connectome of the brain and ventral nerve cord of an adult female fruit fly is reconstructed and annotated, providing an open resource that reveals neural control of behaviour to be distri...

Open-source resource poised to propel research on how nervous systems work

Open-source resource poised to propel research on how nervous systems work

The 4D Nucleome (4DN) program, funded by the National Institutes of Health Common Fund, was established in 2015 to map the three-dimensional organization of ...

Our genomes are highly structured, which facilitates gene regulation. An ambitious project has catalogued the organization of DNA in the nuclei of human cells.

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

Our genomes are highly structured, which facilitates gene regulation. An ambitious project has catalogued the organization of DNA in the nuclei of human cells.

A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...

Li and Kumar et al. created strains expressing Chrimson in specific TRN subtypes and conducted high-throughput behavioral analysis after optogenetically activating them singly or in combination. They found that although the entire touch circuit integrates opposing stimuli linearly, this balance is lost if only part of the circuit is activated.

Artificial intelligence and human expertise meet to generate a map of all the connections in the fly brain. The resource is already being used by experimentalists and theoreticians to further our unde...

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