Indole-producing Escherichia coli worsens ischemic stroke through the activation of aryl hydrocarbon receptor signaling in dendritic cells. Limiting AHR signaling in DCs promotes gut-derived DC migrat...

When considering what shapes animal development, factors such as genetics come to mind. For a queen bee, however, her special wax home also has a role.

Combining a computational framework and optogenetic and chemogenetic manipulations within and downstream of the cortico-basal ganglia circuit identifies the specific cortico-basal ganglia synapse...

Nature Microbiology - A multi-omics approach reveals host–microbiome interactions in aging in mice.

Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognit...

Neuroscientists demonstrate how specific neurons in the brainstem control these behavioural strategies in mice.

Wu et al. provide new insights into how aspartame consumption exacerbates atherosclerosis through an insulin-dependent mechanism. Aspartame-triggered high insulin levels upregulate the endothelial mem...

Nature - A review of studies on communication between the nervous and immune systems redefines the neuroimmune connectome with a focus on health and disease, and discusses how the latest techniques...

Intermittent fasting (IF) is generally associated with improved metabolism, but whether there are age-dependent limitations of IF needs to be explored. Matta et al. now demonstrate that while IF impro...

Zhu et al. employed multi-omics analysis to reveal critical links among the gut microbiome, the gut metabolome, and anti-PD-1/PD-L1 therapy response. Five distinct enterotypes with unique metabolic pr...

Nature Communications - Here, the authors perform a global analysis of over 3000 infant gut samples revealing a universal pattern of microbial changes over the first 1.5 years, with declines in...

clusterProfiler is a tool for characterizing and visualizing omics data. The example procedures show integration of metabolomics and metagenomics analyses, characterization of transcription factors an...

Using 21,561 individuals, the authors present a cross-sectional study of how gut microbiome signatures are associated with dietary intake patterns and with host health outcomes.

Background The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass on microbial colonization to its offspring. However, the l...

Xin et al. find that in the dorsomedial prefrontal cortex (dmPFC), layer 2/3 neurons projecting to the anterior basolateral amygdala promote losing, whereas layer 5 neurons projecting to the dorsal raphe nucleus and periaqueductal gray promote winning. Moreover, the lose-related pathway inhibits the win-related pathways through local GABAergic interneurons.

This study models early life stress (ELS) to observe sex-specific effects on fear memory formation using innovative unsupervised classification together with cellular metabolism alterations in key str...

Madhavan et al. identify and characterize the selective regulation of protein solubility by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure rescues cell-based and C. ele...

Large language models (LLMs) can synthesize vast amounts of information. Luo et al. show that LLMs—especially BrainGPT, an LLM the authors tuned on the neuroscience literature—outperform experts in pr...

Lüthi and colleagues show that activity of the locus coeruleus (LC) is crucial for the cyclic alternation between non-rapid-eye-movement and rapid-eye-movement sleep. Stressful experiences during waki...

Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...

Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome.

After recent changes to Elon Musk’s X, a gradual migration turns into a stampede