Reposted by Akatsuki Saito
New preprint led by our MSc student Wenye Li!! 🎉
@systemsvirology.bsky.social
What we find is a historic genetic interplay between sarbecoviruses and their horseshoe bat hosts' ACE2 receptor! 🦇 🧵...
www.biorxiv.org/content/10.1...
biorxiv.org
Genetic diversity in horseshoe bat ACE2 and sarbecovirus spike proteins mutually shape one another
Angiotensin-converting enzyme 2 (ACE2) serves as the entry receptor for a wide diversity of sarbecoviruses naturally harboured by horseshoe bats (genus Rhinolophus ). Despite the extensive circulation...