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The discovery of the resistosome was a milestone in plant immunity. Here, Zhong et al. identify a kinase that phosphorylates the NLR, and reveal how this kinase regulates resistosome assembly to fine-...

Characterization of four SALICYLIC ACID-DEFICIENT GENEs in rice identifies an ancestral pathway for biosynthesis of salicylic acid from phenylalanine and provides genetic targets for engineering disea...

Diverse plant species synthesize salicylic acid from phenylalanine through a pathway that includes a conserved triple-enzyme module that converts benzoyl-CoA to salicylic acid.

The salicylic acid (SA) biosynthesis pathway—involving ligation of benzoyl coenzyme A and benzyl alcohol to give benzyl benzoate; hydroxylation of benzyl benzoate to give benzyl salicylate; and cleava...

Eukaryotes detect biomolecules through surface-localized receptors, key signaling components. A subset of receptors survey for pathogens, induce immunity, and restrict pathogen growth. Comparative gen...

This study shows that RWT4, a wheat tandem kinase, confers resistance to the fungal pathogen Magnaporthe oryzae by directly binding to the pathogen effector AvrPWT4 and activating host defense.

Tandem kinase proteins underlie the innate immune systems of cereal plants, but how they initiate plant immune responses remains unclear. This report identifies wheat protein wheat tandem NBD 1 (WTN1)...

The role of nucleotide-binding leucine-rich repeat (NLR) receptors in plant immunity is well studied, but the function of a class of tandem kinases (TKs) that confer disease resistance in wheat and ba...

Since President Donald Trump took office on January 20,4a series of executive actions have shaken the research community. Several executive orders were released that targeted diversity, equity, and in...

In plant immunity, sensor NLR resistosomes can generate heterotrimer complexes comprising the helper NLR NRG1, and investigation of cryo-EM structures shows the mechanisms of these heterotrimers in im...

In Arabidopsis, mechanisms for NRG1A activation by recognition of a modified host EDS1–SAG101 complex, and NRG1A inhibition by NRG1C through sequestration of activated EDS1–SAG101, show activation and...

Cell Death & Differentiation - Mechanisms of regulated cell death during plant infection by the rice blast fungus Magnaporthe oryzae

Climate warming influences disease development by targeting critical components of the plant immune system, including pattern-triggered immunity (PTI), effector-triggered immunity (ETI) and production...

Abstract. Coumarins are a family of plant-derived secondary metabolites that are produced via the phenylpropanoid pathway. In the past decade, coumarins ha

Genus Phytophthora threat various plant species including fruit, vegetable, and flower crops. The authors report that some NLRs recognize conserved effector families of multiple Phytophthora species a...