iiinova — where your digital self keeps evolving

Ruth Franklin @ruthfranklinlab.bsky.social · 13/06/2026

🎉 New preprint from @aybv.bsky.social, grad student extraordinaire!! He found an unexpected function for IFN-I: priming the lung epithelium for repair! (With some help from our beloved macrophages). Congrats to Alan and the rest of the coauthors!

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Ruth Franklin @ruthfranklinlab.bsky.social · 22/03/2026

New preprint to share! Incredible collab w/ Fei Chen’s lab: developed in vivo CRISPR screening platform for 🫁 epithelium, allowing single cell perturbation in post-flu repair. Take a peek to see what we found! Huge congrats to the leaders of this work @daisyah.bsky.social & @sundakao.bsky.social 🎉

biorxiv.org

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Ruth Franklin @ruthfranklinlab.bsky.social · 14/03/2026

Another fabulous pre-print from the McKinley lab!

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Ruth Franklin @ruthfranklinlab.bsky.social · 08/01/2026

🎉🎉🎉 Can’t wait to see the amazing science that is sure to come from the Sullivan lab!!!

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Ruth Franklin @ruthfranklinlab.bsky.social · 20/12/2025

Congrats, Megan!! Fantastic news!!

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Ruth Franklin @ruthfranklinlab.bsky.social · 10/10/2025

So exciting to see this out!! More cool biology sure to come!! 🤩👀

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Ruth Franklin @ruthfranklinlab.bsky.social · 14/09/2025

Had a fantastic visit @roswellpark.bsky.social for the Post-Doctoral Symposium!! So many inspiring scientists doing cool work! Grateful for the invitation!

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Ruth Franklin @ruthfranklinlab.bsky.social · 21/08/2025

Can’t wait to read this!! Sure to be a fantastic resource! #InterferonPower

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Ruth Franklin @ruthfranklinlab.bsky.social · 11/07/2025

Thanks, Igor! We’re super excited!

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Ruth Franklin @ruthfranklinlab.bsky.social · 11/07/2025

This project first started during my postdoc w/ Ruslan Medzhitov and I’m extremely grateful for his support! And finally, thank you to the reviewers, @sarahhross.bsky.social & the team @science.org, we’re thrilled to see this story in print! 9/fin

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Ruth Franklin @ruthfranklinlab.bsky.social · 11/07/2025

A huge thank you to the incredible members of my lab who made it all happen, especially @daisyah.bsky.social & Patricia, and all the coauthors for their contributions along the way! 8/n

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Ruth Franklin @ruthfranklinlab.bsky.social · 11/07/2025

tldr: Macrophage-derived OSM enables lung repair during inflammation. This opens the door to therapies that stimulate repair without compromising antiviral responses. 7/n

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Ruth Franklin @ruthfranklinlab.bsky.social · 11/07/2025

We also found an intriguing role for OSM in maintaining the transcriptional states of ATIIs, an area with many open questions! 6/n

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Ruth Franklin @ruthfranklinlab.bsky.social · 11/07/2025

We first thought that OSM was directly suppressing IFN-I, but with more digging (& insightful reviewer comments!), we discovered that OSM promotes ATII epithelial cell proliferation in the context of IFN-I --> a new mechanism of disease tolerance during infection and tissue damage! 5/n

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Ruth Franklin @ruthfranklinlab.bsky.social · 11/07/2025

Cue the macrophages! We focused on a cytokine they produce: OSM. Linked to inflammatory diseases, the role of OSM during steady state & acute infection was unclear. To our surprise, in response to flu or viral mimic, we found increased IFN-I and decreased host survival in the absence of OSM. 4/n

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Ruth Franklin @ruthfranklinlab.bsky.social · 11/07/2025

IFN-I is a key antiviral mediator, but also leads to immunopathology, including epithelial cell death and antiproliferative effects. Despite this, lungs undergo rapid repair after infection, suggesting a mechanism that drives proliferation in the context of IFN-I and tissue damage. 3/n

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Ruth Franklin @ruthfranklinlab.bsky.social · 11/07/2025

Tissue damage is an unavoidable consequence of infections. At mucosal surfaces like the lung, the body must balance fighting pathogens with rapidly repairing damage; both are essential for survival. 2/n

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Ruth Franklin @ruthfranklinlab.bsky.social · 30/06/2025

Was so much fun to catch up with some of my IMP family!!

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Reposted by Ruth Franklin

Jennifer Waters @jencwaters.bsky.social · 23/06/2025

"The money the government sends to Harvard is, in effect, not a subsidy to advance the university’s mission. It’s a payment for the role Harvard plays in advancing the research mission of the United States." www.nytimes.com/interactive/...

nytimes.com

Here Is All the Science at Risk in Trump’s Clash With Harvard (Gift Article)

More than 900 research grants worth $2.6 billion are in jeopardy. So is the 80-year-old model of American science.

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Ruth Franklin @ruthfranklinlab.bsky.social · 30/05/2025

Today was a happy day!! Very proud of Dr. Rodríguez-Morales and very proud to be a professor at Harvard!!

PhD student and doctoral advisor standing outside of Harvard Medical School on graduation day

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Reposted by Ruth Franklin

Dr. David Miller 🏳️‍🌈 @davidimiller.bsky.social · 21/05/2025

🚨 Action alert: Two days left!! Help protect NSF/NIH from political interference. 👎 A new rule (Sched. F) would allow for replacing career program officers with political appointees. ➡️ Action: Object here by THIS FRIDAY. Comments can be brief and/or anonymous. Helps future litigation.

federalregister.gov

Improving Performance, Accountability and Responsiveness in the Civil Service

The Office of Personnel Management (OPM) is proposing a rule to increase career employee accountability. Agency supervisors report great difficulty removing employees for poor performance or misconduc...

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Reposted by Ruth Franklin

Jon Levy @jonlevybu.bsky.social · 15/05/2025

On a day when all research grants at Harvard were terminated, and in a context where Congress seems to broadly accept the notion that destroying science and health research in the US is fine, it’s worth noting that this is not what the public wants.

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Ruth Franklin @ruthfranklinlab.bsky.social · 15/05/2025

I’m so so sorry. It’s absolutely horrific 😔

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Ruth Franklin @ruthfranklinlab.bsky.social · 15/05/2025

Just said goodbye to my NIH MIRA award. Really hurts to see the word “terminated” in writing. Even worse to see it next to the F31 awarded to a fantastic PhD student in my lab @aybv.bsky.social. I REFUSE to let this stop us!!!

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