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Russ Corbett-Detig

@russcd.bsky.social
318 followers 177 following 35 posts

I like my data small. corbett.ucsc.edu

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Reposted by Russ Corbett-Detig
Molly Przeworski @mollyprz.bsky.social · 11/09/2026
Job opportunity at Columbia U., in "any combination of field, experimental, computational, or theoretical approaches to study fundamental questions in evolutionary biology".
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Russ Corbett-Detig @russcd.bsky.social · 27/08/2026
Hard to beat days when I have time to walk/hike home.
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Kristian G. Andersen @kgandersen.bsky.social · 24/08/2026
We have a (dry lab) Postdoc Position in Viral Genomics & Pathogen Surveillance here in wonderful and sunny San Diego 🏄‍♂️☀️! We're looking to continue to build our AI and broader infectious disease surveillance efforts, with a focus on our outbreak.info platform. Read more: andersen-lab.com/about/
andersen-lab.com
About | Andersen Lab
Learn more about the Andersen Lab, as well as jobs and career opportunities.
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Matthew Hahn @3rdreviewer.bsky.social · 02/07/2026
My abiding memory of a wonderful #SMBE2026:
A photo of Danny DeVito
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Pratik Katte @pratikkatte.bsky.social · 09/06/2026
Excited to be presenting my poster on Lorax at #PEQG26! Lorax is a GPU-accelerated, web-native tool for real-time interactive visualization of Ancestral Recombination Graphs. If you're at Asilomar this week, come check it out. Would love to chat about scalable ARG exploration and get your feedback
lorax.ucsc.edu
Lorax
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Pratik Katte @pratikkatte.bsky.social · 07/04/2026
Pangenomes, but scalable. Panmap: phylogeny-guided framework for read alignment, genotyping, sample placement on pangenomes. 600x smaller indexes, faster builds, and placement from 20K to 8M genomes. @amkram.bsky.social @alanbyzhang.bsky.social @russcd.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
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Russ Corbett-Detig @russcd.bsky.social · 31/03/2026
eDNA is possibly the coolest application! Below: read-level placement across a pan-vertebrate mitochondrial pangenome (left) where a clear cluster of read assignments supports the presence of many mammoth reads (right). Processing ~9 billion reads took just 8 minutes!
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Russ Corbett-Detig @russcd.bsky.social · 31/03/2026
Even in complex mixtures, Panmap does a really good job of sorting out their identities and relative contributions to the sample.
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Russ Corbett-Detig @russcd.bsky.social · 31/03/2026
Panmap can also evaluate sample mixtures (e.g., what you get from wastewater or eDNA), by scoring the reads separately against every node and then estimating the abundances of lineages via EM.
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Russ Corbett-Detig @russcd.bsky.social · 31/03/2026
Because we score placements dynamically during a single tree traversal, it is very fast. Panmap takes less than one second to place a SARS-CoV-2 sample onto a 20,000 sample phylogeny, align the read, and call genotypes.
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Russ Corbett-Detig @russcd.bsky.social · 31/03/2026
Panmap gets really accurate placements, even at very low sequencing depths.
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Russ Corbett-Detig @russcd.bsky.social · 31/03/2026
There is a ton of cool stuff you can do using the index. In the first application, Panmap place a single sample onto the tree *without assembly* using the raw reads and then can align and genotype based on this closest known relative.
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Russ Corbett-Detig @russcd.bsky.social · 31/03/2026
The central innovation of Panmap is indexing PanMANs by producing a “syncmer annotated tree”, where seed edits are stored only where sequences on the phylogeny change (including inferred ancestors). The index therefore exploits a type of “phylogenetic compression” and is very compact.
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Russ Corbett-Detig @russcd.bsky.social · 31/03/2026
This is the result of our incredibly rewarding collaboration with Yatish Turakhia and members of his lab. In particular, and foundational to our work, we previously developed the underlying phylogenetic Pangenome data structure, PanMAN. www.nature.com/articles/s41...
nature.com
Compressive pangenomics using mutation-annotated networks - Nature Genetics
Pangenome Mutation-Annotated Network (PanMAN) is a pangenome data structure that encodes shared mutational and evolutionary histories across microbial genomes, providing both high compression and enha...
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Russ Corbett-Detig @russcd.bsky.social · 31/03/2026
Alex Kramer, Alan Zhang and friends posted our preprint today. In it, we introduce Panmap, a tool for phylogenetic placement, assembly, lineage abundance estimation, and eDNA assignment using phylogenetic pangenomes. www.biorxiv.org/content/10.6...
biorxiv.org
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Josh Levy @josh-levy.bsky.social · 10/03/2026
Open question for anyone that develops/maintains of bioinformatics tools, especially those used for public health - what do you think is the right way to fund this long term? Grants are great for new research directions, but aren't really appropriate for most tool dev/maintenance.
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Russ Corbett-Detig @russcd.bsky.social · 04/03/2026
Disclaimer: I am a terrible web developer and this extension should not be used by anyone.
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Russ Corbett-Detig @russcd.bsky.social · 04/03/2026
The chrome extension can do this for you! github.com/russcd/coreP...
github.com
GitHub - russcd/corePivotal
Contribute to russcd/corePivotal development by creating an account on GitHub.
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Russ Corbett-Detig @russcd.bsky.social · 03/03/2026
Thanks so much, Ian! This means a lot coming from a mighty core-pivotal 17.
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Russ Corbett-Detig @russcd.bsky.social · 03/03/2026
I’m already getting community feedback on the core-pivotal index. I truly appreciate it. But in the spirit of core-pivoteering, I will only implement suggestions from whoever has the highest core-pivotal index.
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Russ Corbett-Detig @russcd.bsky.social · 24/02/2026
Why this matters: As biobanks + population sequencing projects scale into the hundreds of thousands (and millions), the bottleneck isn’t just inference. It’s exploration. Feedback welcome 🌲
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Russ Corbett-Detig @russcd.bsky.social · 24/02/2026
Truly, we harvest the truffulas standing on very tall shoulders.
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Russ Corbett-Detig @russcd.bsky.social · 24/02/2026
On the visuals inspiration side: a huge thanks to @theo.io and Taxonium. Taxonium showed the community that we can interactively explore enormous phylogenetic trees in the browser at pandemic scale. Lorax brings a similar philosophy to ARGs.
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Russ Corbett-Detig @russcd.bsky.social · 24/02/2026
Under the hood, Lorax runs on the incredibly powerful data model + API from tskit, developed by Jerome Kelleher and collaborators. Tree sequences make it possible to store and traverse genome-wide genealogies efficiently, and Lorax uses that structure directly in the backend.
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Russ Corbett-Detig @russcd.bsky.social · 24/02/2026
What does Lorax do? It lets you dynamically explore tree sequences at massive scales - zooming through local trees, inspecting mutations, querying ancestry. Built for *huge* datasets with up to millions of samples.
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Russ Corbett-Detig @russcd.bsky.social · 24/02/2026
tl;dr: Read about Lorax: www.biorxiv.org/content/10.6... Try Lorax: lorax.ucsc.edu/view/1kg_chr... Install Lorax: pypi.org/project/lora...
biorxiv.org
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Russ Corbett-Detig @russcd.bsky.social · 24/02/2026
@pratikkatte.bsky.social and I just released Lorax 🌲, a tool for interactive exploration of biobank-scale ancestral recombination graphs (ARGs). If you’ve ever wanted to scroll across the ancestries of thousands of genomes… this is for you.
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Bloom lab @jbloomlab.bsky.social · 20/02/2026
We have posted data providing real-time measurement of human neutralizing antibody landscape to seasonal influenza. Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine.
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Zamin Iqbal @zaminiqbal.bsky.social · 09/02/2026
A long time ago in a galaxy far away, there was a SARS-CoV-2 pandemic. Our paper, led by @martibartfast.bsky.social a) correcting errors in 4.5 million genomes & their phylogeny b) improving representation of the Global South in public data www.nature.com/articles/s41... (thread 1/n)
nature.com
Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny - Nature Methods
This Resource paper presents a global SARS-CoV-2 phylogenetic tree of 4,471,579 high-quality genomes consistently constructed by Viridian, an efficient amplicon-aware assembler.
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Molecular Biology and Evolution @molbioevol.bsky.social · 15/12/2025
@cademirch.bsky.social @erikenbody.bsky.social TB Sackton & @russcd.bsky.social introduce Callable Loci And More (clam), a tool that leverages callable loci to accurately estimate population genetic statistics (π, dxy, and FST). 🔗 doi.org/10.1093/molbev/msaf282 #evobio #molbio #compbio
doi.org
Efficient Estimation of Nucleotide Diversity and Divergence Using Callable Loci (and More)
Abstract. The increasing scale of population genomic datasets presents computational challenges in estimating summary statistics such as nucleotide diversi
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Genome Biology and Evolution @genomebiolevol.bsky.social · 05/12/2025
Genetti & @russcd.bsky.social investigated Puerto Rico honeybees, suggesting that local pressures on bee behavior may have induced changes in alleles linked to different ancestries at loci involved in neuronal development, behavior, and mating. 🔗 doi.org/10.1093/gbe/evaf217 #genome #evolution
doi.org
Signals of Ancestry-Specific Selection in Gentle Africanized Honey Bees
Abstract. Understanding the genetic basis of adaptive responses to environmental and human mediated pressures is a central concern in evolutionary biology.
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Russ Corbett-Detig @russcd.bsky.social · 03/12/2025
I am 100% stoked to lead this effort again this year! Come on out to beautiful Santa Cruz and show off your awesome-est science.
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Bloom lab @jbloomlab.bsky.social · 20/08/2025
Our lab has an opening for a research technician to contribute to our efforts to understand RSV evolution & its impact on antibody countermeasures (see journals.asm.org/doi/full/10....). The tech will also help w lab management. If interested, apply here: careers-fhcrc.icims.com/jobs/29940/job
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Russ Corbett-Detig @russcd.bsky.social · 28/06/2025
Thank you! I might need to steal this wonderful artwork!
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Vincent CASTRIC @vincentcastric.bsky.social · 13/06/2025
Super glad to see this out ! Lovely collaboration with @russcd.bsky.social @crouxevo.bsky.social and the groups of @meauxjuliette.bsky.social @plantadaptation.bsky.social
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Russ Corbett-Detig @russcd.bsky.social · 01/05/2025
More generally, my approach is a part of a "functional surveillance" paradigm where we infer changes in the functional properties of pathogens using genome sequence data.
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Russ Corbett-Detig @russcd.bsky.social · 01/05/2025
Hey! That's me! Check out my latest where I develop a method for pinpointing where mutation spectra change along phylogenies. Striking, nodes with large changes are significantly enriched for protein changes in the RdRp (catalytic domain of the polymerase) suggesting a causal role.
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Russ Corbett-Detig @russcd.bsky.social · 25/04/2025
Would you consider applications from a slightly more senior postdoc? ... Asking for a friend, of course. :)
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Zamin Iqbal @zaminiqbal.bsky.social · 09/04/2025
So glad this is finally out. The method has been instrumental in allowing us to compress the AllTheBacteria data - ~2 million bacterial genomes shrink from 3Terabytes (gzipped) to 100Gb using phylogenetic compression. Great work by @brinda.eu
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Matthew Hahn @3rdreviewer.bsky.social · 10/04/2025
Not really my announcement to make--I am but a lesser co-author--but IQ-TREE 3 has just been released! (Most credit to Minh Bui and @roblanfear.bsky.social and their labs) ecoevorxiv.org/repository/v...
ecoevorxiv.org
IQ-TREE 3: Phylogenomic Inference Software using Complex Evolutionary Models
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Russ Corbett-Detig @russcd.bsky.social · 10/04/2025
This is absolutely fascinating! Impressive analysis (3.2M TEs in 1.9K samples) and super interesting examples of locally adaptive TE insertions. Congrats to @tobybarilbio.bsky.social and all the authors.
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Ryan Gutenkunst @ryangutenkunst.bsky.social · 24/01/2025
Our paper on fitting population genetic models to low-pass sequencing data is now out in Molecular Biology and Evolution! doi.org/10.1093/molb...
Comparison of allele frequency spectra for 3x coverage, with and without our bias model.
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Richard Neher @neher.io · 11/01/2025
Building on the UShER tree of millions of SARS-CoV-2 genomes maintained by Angie Hinrichs, Hugh Haddox and Georg Angehrn (and others in @matsen.bsky.social lab and @jbloomlab.bsky.social) have looked into how the neutral mutation rate varies along the genome: [1/N] www.biorxiv.org/content/10.1...
biorxiv.org
The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure
RNA viruses like SARS-CoV-2 have a high mutation rate, which contributes to their rapid evolution. The rate of mutations depends on the mutation type (e.g., A→C, A→G, etc.) and can vary between sites ...
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Bianca De Sanctis @bdesan.bsky.social · 02/01/2025
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Russ Corbett-Detig @russcd.bsky.social · 16/12/2024
Delighted to organize the Next-Wave Symposium again this year! If you are an awesome postdoc in genomics---very broadly defined---come tell us about your amazing science!
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Russ Corbett-Detig @russcd.bsky.social · 26/11/2024
I think we need a bit more information here to really help. Especially: how divergent are the genomes on average?
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Duncan MacCannell @drm.bsky.social · 14/11/2024
There's a lot of uncertainty about the future right now. I'd like to do something constructive: if you teach students in #publichealth, #microbiology, #genomics, #bioinformatics, I'd be happy to talk about CDC AMD, #fellowships, gov sci and career paths. #microsky #blackinmicro 🧬🖥️ www.cdc.gov/amd
cdc.gov
Advanced Molecular Detection (AMD)
CDC’s Advanced Molecular Detection program leads national efforts to develop and expand the use of
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Russ Corbett-Detig @russcd.bsky.social · 23/08/2024
It's on.
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Angie Hinrichs @angieshinrichs.bsky.social · 21/06/2024
Got milk virus genomes? (or any H5N1?) Throw them at usher.bio and see where they land in per-segment trees of tens of thousands of public Influenza A H5N1 sequences!
usher.bio
UCSC UShER: Upload
UCSC Genome Browser
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Toby Baril @tobybarilbio.bsky.social · 06/06/2024
Excited to dig into this - very cool work from @russcd.bsky.social‘s lab! 🙌 #TEworldwide #TEsky
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