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Josef M Klein @resurgequality.bsky.social · 09/10/2026

No matter what they decide about clinical significance, not correcting it is definitely not the way to go.

Reposted by Josef M Klein

Martin Plöderl @ploederl.bsky.social · 01/10/2026

29/ This shows that even a small zombie trial can severely “infect” the overall results of a NMA. Furthermore, this shows that unreliable/zombie trials can be undetected with classic risk of bias analysis.

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Martin Plöderl @ploederl.bsky.social · 01/10/2026

27/ Nonetheless, we were able to closely reproduce the findings of the three NMAs. !!! Main finding: excluding the zombie trial resolved inconsistencies between the Lancet and Cochrane NMAs and also inconsistencies between direct and indirect evidence in the Lancet NMAs

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Josef M Klein @resurgequality.bsky.social · 09/10/2026

Always great when bubbles collide and such a broad channel as sci-show features such a small bubble with big relevance.

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Josef M Klein @resurgequality.bsky.social · 06/10/2026

Acfffdf£dddfff_off FCC's CCTV vvvvvgttttttttttttfftttttttUIIU+IUUUJHJUHHHHHHHHHH

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Josef M Klein @resurgequality.bsky.social · 01/10/2026

OK now that I read the excerpt I can actually understand why he talks like this. It's his typical schtick: short answer, mention and diffuse many other attacks on him. Trying to point out great things while critisizing the press. Where is the wow I expected after reading those 4 comments?

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Nick DeVito @ndevito1.bsky.social · 28/09/2026

Oof…following in the footsteps of Cochrane UK.

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Josef M Klein @resurgequality.bsky.social · 30/09/2026

If a machine is deterministic& its insides &operations transparent, then I trust its outputs more than any humans. It's the nondeterministic execution of LLM's that stops us. The solution though is right at hand: deterministic validation for nondeterministic generation. Exactly what we do for humans

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Josef M Klein @resurgequality.bsky.social · 29/09/2026

Amazing story. I thought immediately of a stray H atom, the moment the mass difference was revealed. But not of isotopes. Although it makes absolute sense in retrospect. Using deuterium to change your molecules properties. Ultra advanced pharmacokinetics.

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Reposted by Josef M Klein

Max Kozlov @maxkozlov.bsky.social · 25/09/2026

SCOOP: Top researchers at Columbia, Stanford, and others thought they were elected to elite scientific societies alongside Nobel laureates. The catch? The organizations are a sham. I spent the last month diving deep into a massive academic scam spanning continents, for @nature.com

nature.com

Exclusive: Sham scientific societies are misleading star researchers

A Nature investigation reveals a network of organizations that have been building their ranks through deceptive practices.

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Josef M Klein @resurgequality.bsky.social · 24/09/2026

A win for databases. It is a mess out there.

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Stella Creasy MP @stellacreasy.bsky.social · 11/09/2026

It’s not too late to stop this madness - the government has said the uk mega donors are a problem. The lords can bring in a cap on UK donors to stop any attempt to buy the next election. Share this and ask your MP to join us protecting British democracy.

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Josef M Klein @resurgequality.bsky.social · 08/09/2026

Your law is kinda funny. Enforcing it also means enforcing pardons. Which means not enforcing it.

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Josef M Klein @resurgequality.bsky.social · 01/09/2026

I feel strongly about pubpeers ToS as well. No automation allowed for downloading..

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Josef M Klein @resurgequality.bsky.social · 31/08/2026

Where do those antibodies come from? Who is ehe big culprit behind it, or is it a distributed network? No way all vendors planned this individually

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Josef M Klein @resurgequality.bsky.social · 31/08/2026

His is such an enormous clusterfudge I can't reach the end if the thought here. -False claims act (sold to USGov) -Class action lawsuit (customers) -Papers that used these antibodies -Papers that built on them -All the failed experiments that need to be revisited -all the money lost..what else?

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Reese Richardson @reeserichardson.bsky.social · 25/08/2026

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

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Reposted by Josef M Klein

Fabian Wittmers @academic-integrity.bsky.social · 28/08/2026

Wiley's Research Integrity team tells me: "investigation has concluded that there are no serious concerns about the citation activity" Guo has been fired/left his University after I reported his citation extortion practices, so something isn't adding up here... pubpeer.com/publications...

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Reposted by Josef M Klein

Derek Lowe @dereklowe.bsky.social · 18/08/2026

Thoughts on the latest Alzheimer’s data scandal:

science.org

More Alzheimer's Research Trouble

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Reposted by Josef M Klein

Ian Hussey @ianhussey.mmmdata.io · 14/08/2026

I’ve been told for years that it’s legally and ethically impossible to share medical RCT data. In 2024, the BMJ made sharing anonymised data mandatory, and now lots* of folk do it. Interesting how the barriers evaporated like that, isn’t it? *not everyone, compliance problems exist.

medrxiv.org

Availability of clinical trial individual patient data in the BMJ before and after adoption of a stringent data-sharing policy, compared with recent rates at other major medical journals

Background In 2024, the BMJ updated its data-sharing policy for clinical trials, requiring open deposit of deidentified individual participant data (IPD) before publication. We considered whether data...

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Josef M Klein @resurgequality.bsky.social · 14/08/2026

If there is a profitable demand and a service one can privide that is not illegal, then nature has to provide the service, I mean everything else is gross negligence towards stockholders.

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Josef M Klein @resurgequality.bsky.social · 14/08/2026

This is just a profitable service for the ones who would like to pay for a chance at another paper in their cv, while testing the speed and consistency of the retraction system.

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Josef M Klein @resurgequality.bsky.social · 12/08/2026

ResearchBox according to some restractionwatch link I read today.

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Retraction Watch @retractionwatch.com · 11/08/2026

This company pitched us a guest post on "retracted trials that live on inside meta-analyses." Perfectly reasonable subject, but the text seemed fishy. Turns out it was *very* fishy, we now learn thanks to @emanuelmaiberg.bsky.social of @404media.co.

404media.co

Company Offering ‘100% Human-Written, Never AI’ Medical Research Is Entirely AI

Research Gold's team of human methodologists are either AI generated or using the identity of real people without their permission

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Josef M Klein @resurgequality.bsky.social · 09/08/2026

I fear 6 supreme court judges don't care about the constitution... and will permanently overthrow it.. By the authority of 6 people owning you... to allow unlimited donations from anyone... So the candidate does what the donor wants.... United Sold America.

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Lawrence Lessig @lessig.bsky.social · 08/08/2026

I spoke to Weekend Edition's Scott Simon about the Maine initiative to end Super PACs (now being considered by the First Circuit): www.npr.org/2026/08/08/nx-s1-592246…

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Josef M Klein @resurgequality.bsky.social · 08/08/2026

Isn't the trump chosen supreme court the worst to decide over that? Didn't they recently vote to allow unlimited political sponsorship in The Supreme Court’s recent 6–3 decision striking down political party spending limits (NRSC v. FEC?

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Josef M Klein @resurgequality.bsky.social · 08/08/2026

Some CSU associate bought a diploma on homeopathy real fast and made some serious money.

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Martin Plöderl @ploederl.bsky.social · 07/08/2026

How to waste 800,000 💶, Bavarian style..🙄

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Josef M Klein @resurgequality.bsky.social · 07/08/2026

I am glad you people have somehow found the funding or time for this. If I were free to do anything I would probably also do this. Well maybe one day I can actually work on this side of history... Science with 100% data provenance is the golden grail and the future infrastructure anyways..

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Josef M Klein @resurgequality.bsky.social · 07/08/2026

And does it shift the Systematic reviews outcomes? This is exactly the kind of stuff expected to occur to either unintentionally shift results (studies hiding behind assumed truths) or sway them on purpose (conflict of interests). Its even in cardio. That's the stuff James Heathers should work at.

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Reposted by Josef M Klein

Dead Neanderthals @deadneanderthals.bsky.social · 06/08/2026

We published a new paper in the #CanadianJournalOfCardiology doi.org/10.1016/j.cj... We show that 57 of 201 included articles (28.4%) contain image-related or data-related issues. All these papers investigated microvascular injury after acute myocardial infarction in mouse, rat and pig models.

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Josef M Klein @resurgequality.bsky.social · 31/07/2026

He slowly brings material to the moon. I bet that is the secret plot. There is so much distance between earth and the moon there is almost no Chance this is an accident. It would have to be a later stage booster for Mars or so maybe. But then still super unlikely. Not the first time though.

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Josef M Klein @resurgequality.bsky.social · 31/07/2026

1) Na toll, jetzt gibts nur noch Wildoktopus und die population schwindet. Kein Zucht-Bio Oktopus.

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Josef M Klein @resurgequality.bsky.social · 31/07/2026

Isn't the idea of a preregistration to not change the goalposts anymore after shooting? I mean sure in such a case you can do it all beforehand and make it seem like you did it afterwards to completely circumvent the purpose of prereg. But the naive mind might catch some real good will with this.

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Josef M Klein @resurgequality.bsky.social · 31/07/2026

Now this is interesting as I really wonder how so many legitimate analytical decisions can be made (I know it as Vibration of Effects (VoE) Analysis), without somehow opposing ones goal when testing a hypothesis.

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Josef M Klein @resurgequality.bsky.social · 30/07/2026

I was just surprised how it worked for INSPECT-SR rather well it looks like.

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Josef M Klein @resurgequality.bsky.social · 30/07/2026

Peter Doshi did sponsor individual patient level data reviews with RIAT to find deeper hidden problems in clinical trials, below the optimistic summary. FDA & EMA rarely do it. It takes a lot of time/ about a year to do it for 1 person. But problems can be found that change results.

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Josef M Klein @resurgequality.bsky.social · 30/07/2026

Probly needs to be rerun 4-5 times & the positives need to be reviewed & the false negative rate tested with existing IPLD-reviews bc of the high error rate in retrieval based tasks. But when one is there & knows how offen it has to be rerun 2 get low error we can automate this rare necessity.

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Josef M Klein @resurgequality.bsky.social · 30/07/2026

Well take Claude code assistant or open claw with some LLM you want, get the Individualität Patient level data of a trial and review it for consistency (like done by RIAT etc) to find deeper problems in clinical triala, not via Hand but automatically.

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Josef M Klein @resurgequality.bsky.social · 30/07/2026

Agentic individual Padient Data reviews... How much that would cost..?

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Josef M Klein @resurgequality.bsky.social · 24/07/2026

People should really be careful with those kind or jokes. They basically deny that any safety testing is needed before any harm is known. Rather point to data that shows safety than to deny the need for safety. Or go buy your muuuch cheaper Chinese car that had 0 safety testing.

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Reposted by Josef M Klein

Paul Bleicher @pbleic.bsky.social · 24/07/2026

Astonishing. RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist. In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.

nytimes.com

FDA Panel Supports Lifting Restrictions on Four Peptides (Gift Article)

In an all-day hearing, the agency’s scientists argued against allowing broad access to unproven drugs that the agency had banned three years ago.

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