Nature Microbiology, Published online: 30 June 2026; doi:10.1038/s41564-026-02412-5Screening 1,572 compounds for mycomembrane permeation plus cheminformatic and machine learning analyses reveals features associated with improved permeation in the pathogen Mycobacterium tuberculosis and model organism M. smegmatis.

A common rifampicin-resistance mutation in Mycobacterium tuberculosis alters transcription and creates new metabolic vulnerabilities through transcription attenuation, revealing potential targets to c...

An estimated 10.8 million people worldwide were infected with tuberculosis (TB) in 2023, and among those cases, 1.25 million people succumbed to disease (1); 90% of people who become infected with Myc...

A collection of antigen-stabilizable fluorescent nanobodies becomes fluorescent upon binding to their intracellular targets and enables background-free multicolor imaging and biosensing in living syst...

Here, the authors report metabolic activation as a potential antimicrobial strategy against Mycobacterium tuberculosis. They show that supra-physiological activation of L-histidine biosynthesis r...

Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...