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Patrick Zanon

@pzanon.bsky.social
69 followers 173 following 7 posts

Exploring and expanding non-conventional druggable space NEOsphere Biotech. Previously Hacker & Disney labs

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Patrick Zanon @pzanon.bsky.social · 23/06/2026
Excited to share my first major internal research project at NEOsphere! Generating global proteomic profiles for entire cereblon glue libraries, we identified a degrader of the master cell cycle regulator CDK4.
doi.org
Integrated proteomic screening reveals design principles of CRBN molecular glue degraders
Cereblon (CRBN)-based molecular glue degraders (MGDs) induce the degradation of diverse disease-relevant proteins, underscoring their broad therapeutic potential. Here we systematically expand the CRB...
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Reposted by Patrick Zanon
Rob van Montfort @robvanmontfort.bsky.social · 06/02/2026
Excited to share this preprint about the identification of TBK1 molecular glue degraders in a collaboration between NEOsphere Biotechnologies, @pmeier.bsky.social, and the Centre for Protein degradation @icr.ac.uk www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Patrick Zanon
Fengchao @fcyucn.bsky.social · 30/10/2025
This project started 5 years ago. It led us to add isotope-labeling support to #FragPipe/#IonQuant. Since then, the tools have grown so much and are now widely used in #Chemoproteomics. Huge thanks to everyone, and special thanks to @stephanhacker2.bsky.social and @pzanon.bsky.social
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Patrick Zanon @pzanon.bsky.social · 31/10/2025
I am thrilled to see the paper out now and grateful to all coauthors for their contributions to this work! Among a number of changes, we included additional probes as well as experiments in live bacterial cells. So be sure to check it out even if you are already familiar with the preprint!
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Reposted by Patrick Zanon
Jeremy Berg @jeremymberg.bsky.social · 04/06/2025
New powerful article up in the New York Times on cancelled and delayed grants www.nytimes.com/interactive/...
nytimes.com
Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump (Gift Article)
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
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Reposted by Patrick Zanon
David Konrad @dbkonrad.bsky.social · 14/05/2025
We are looking for a PhD candidate in medicinal / organic chemistry with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: jobs.univie.ac.at/job/Universi.... Reposts are very much appreciated!
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