Excited to share my first major internal research project at NEOsphere!
Generating global proteomic profiles for entire cereblon glue libraries, we identified a degrader of the master cell cycle regulator CDK4.
doi.org
Integrated proteomic screening reveals design principles of CRBN molecular glue degraders
Cereblon (CRBN)-based molecular glue degraders (MGDs) induce the degradation of diverse disease-relevant proteins, underscoring their broad therapeutic potential. Here we systematically expand the CRB...