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Andrew S. MacDonald

@profandrewmac.bsky.social
3K followers 690 following 140 posts

Prof at Edinburgh University. #Immunologist. #Inflammation, #infection, #helminths, #allergy, #metabolism and the #microbiome. scholar.google.com/citations?user=g… Not interested in pitchfork politics of any flavour…

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Andrew S. MacDonald @profandrewmac.bsky.social · 23/09/2026
Congratulations Dr Shorthouse! Very proud of Olivia defending her #PhD thesis today - no corrections! And huge thanks to examiners @immunobladder.bsky.social and @kathelse.bsky.social too. @lizziemannlab.bsky.social @lydiabeckeriii.bsky.social
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Andrew S. MacDonald @profandrewmac.bsky.social · 18/05/2026
Congratulations Dr Harrop! Very proud of Ben defending his #PhD thesis today - the future is bright as he starts his postdoc in London! Good luck Ben 😊. And huge thanks to examiners @joyedwardshicks.bsky.social and Jo Konkel too. @lydiabeckeriii.bsky.social
Joy Edwards-Hicks, Jo Konkel and a very Happy newly fledged Dr Ben Harrop, post PhD viva.  All holding glasses of celebratory fizz (of questionable quality).
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Andrew S. MacDonald @profandrewmac.bsky.social · 27/02/2026
Thanks to @minsterbantam.bsky.social for visiting and giving a great seminar this week about #immunity and #hematopoesis during #helminth infection #schistosomiasis 🪱 🧪
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Andrew S. MacDonald @profandrewmac.bsky.social · 15/12/2025
Lovely to catch up with some of the Manchester crew this afternoon, including new addition Maya 👶, for a Christmas get together 😊🎄🎅🏻 @lydiabeckeriii.bsky.social
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Andrew S. MacDonald @profandrewmac.bsky.social · 18/09/2025
The end of #EMDS2025 - so much amazing science, and great to meet up in person with so many friends and colleagues (and make some new ones!). Very proud of @vshek.bsky.social and @nwasowska.bsky.social winning poster prizes for the team - well done both!
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Andrew S. MacDonald @profandrewmac.bsky.social · 18/09/2025
A fantastic talk from David Russell to end #EMDS2025 - about #macrophage subset responses to #Mycobaterium tuberculosis, and their re-programming to improve drug efficacy in vitro and in vivo
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Andrew S. MacDonald @profandrewmac.bsky.social · 18/09/2025
Beautiful data from Franca Ronchese, all the way from @malaghan.bsky.social in New Zealand, about generation and function of subsets of skin #DendriticCells in #allergic responses #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 18/09/2025
Another great talk from @immunobladder.bsky.social about #macrophage subsets in the #bladder, including in memory response to bacterial infection and key differences in males vs females #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 18/09/2025
Final day of #EMDS2025 opens with a fantastic talk from Will Wood - beautiful imaging of #macrophage migration following wounding, using the tractability of #Drosophila in ingenious ways to identify key chemoattractants in this process
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Andrew S. MacDonald @profandrewmac.bsky.social · 17/09/2025
Fantastic talk and new data from @lukeanthonyoneill.bsky.social about #mitochondrial control of #inflammation by #itaconate and derivatives in multiple settings #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 17/09/2025
Really interesting talk from @chrysothemisbrown.bsky.social about ontogeny, transcriptional regulation and function of subsets of #ThetisCells, including their role in #Treg induction and oral #tolerance #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 17/09/2025
Beautiful and energetic talk from @drpetercook.bsky.social about #DendriticCell uptake of and activation by #fungal spores in #allergic airway #inflammation, and metabolic requirements for this #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 17/09/2025
Final talk pre-lunch from @mariolaks.bsky.social defining some of the key #DendriticCell subsets involved in shaping joint #inflammation vs remission, in both human and mouse #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 17/09/2025
Interesting short talk from Anita Qualls about RORgt+ #APCs in oral tolerance and #Treg induction #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 17/09/2025
Another lovely talk, this time from David Munro, about the context dependent roles for #HIF1a in #microglia, including in stroke #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 17/09/2025
First talk so far about #immunometabolism at #EMDS2025 - really interesting murine and human data about mitochondrial (dys)function in #macrophages as a regulator of #inflammation, from @immunometlab.bsky.social
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Andrew S. MacDonald @profandrewmac.bsky.social · 17/09/2025
Lovely talk from Samanta Mariani about embryonic #macrophages in hematopoiesis, in health and in malignancy #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 17/09/2025
Really interesting talk by Barbara Schraml, showing how dietary cues at weaning can activate splenic #cDC1 to induce CTL-like effector CD8+ T cells #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 17/09/2025
Day 2 of #EMDS2025 starts with a beautiful talk about lung tissue resident #alveolar #macrophage identity and the influence of #IL-33 on this, by Stijn Verwaerde from BART Lambrecht’s lab.
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Andrew S. MacDonald @profandrewmac.bsky.social · 16/09/2025
A fascinating education in #LangerhansCell biology and function from Clare Bennett, as well as a closing advert for the 18th International #DendriticCell symposium in San Diego next year #EMDS2025 #DC2026
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Andrew S. MacDonald @profandrewmac.bsky.social · 16/09/2025
Lots of exciting new data from @esegura-lab.bsky.social revealing an important role for Aryl Hydrocarbon receptor #AhR in promotion of wound healing my #macrophages #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 16/09/2025
Fascinating (and disturbing!) presentation about the impact of ingested microplastics on liver macrophages by @mariafviola.bsky.social #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 16/09/2025
Really interesting story from @gastrogrj.bsky.social - murine and human data showing that #activin signaling in intestinal #monocytes is key for epithelial barrier repair during intestinal #inflammation #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 16/09/2025
Lovely talk from Bill Agace about the regional diversity of #dendriticcells in human intestines, in health vs Crohn’s disease #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 16/09/2025
Beautiful discovery science from Catherine Robin about blood resident #macrophages - including some gorgeous imaging in #zebrafish #EMDS2025
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Andrew S. MacDonald @profandrewmac.bsky.social · 16/09/2025
A fantastic talk about liver monocytes and macrophages by @martinguilliams.bsky.social kicks of #EMDS2025 - beautiful application of multiple cutting edge technologies to understand cel-cell interactions in tissues
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Andrew S. MacDonald @profandrewmac.bsky.social · 16/09/2025
#EMDS2025 begins! Looking forward to a few days of exciting science about all things #macrophage, #dendriticcells and #monocytes in beautiful Edinburgh
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Andrew S. MacDonald @profandrewmac.bsky.social · 14/09/2025
Some very important preparation for #EMDS2025 completed! #SMWS membership renewed. Looking forward to some great science, meeting old friends and making new ones in the week to come 🧪 🥃 🏴󠁧󠁢󠁳󠁣󠁴󠁿 😊
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Andrew S. MacDonald @profandrewmac.bsky.social · 02/05/2025
This is more like me nowadays...
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Andrew S. MacDonald @profandrewmac.bsky.social · 28/04/2025
This made me chuckle… #Immunosky 🧪
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Andrew S. MacDonald @profandrewmac.bsky.social · 18/04/2025
Lovely seminar from @grizzlybeard.bsky.social the other day about systemic and local control of #monocyte derived cells in health and #Crohn’s disease. Thanks for visiting Andy! #ImmunoSky 🧪
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Andrew S. MacDonald @profandrewmac.bsky.social · 11/03/2025
Enjoying the view from the ‘office’ today…
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Andrew S. MacDonald @profandrewmac.bsky.social · 07/02/2025
Fantastic workshop today on diverse aspects of #vector borne #disease at the rather gorgeous @edfuturesinstitute.bsky.social - met new people and leave with so many new ideas and possibilities! Thanks @uoe-eid.bsky.social for organising 😊
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Andrew S. MacDonald @profandrewmac.bsky.social · 18/12/2024
Congratulations to Dr Josh Hughes for passing his #PhD viva today! The future of #macrophage #immunometabolism is in safe hands 😊. Thanks to Adam Byrne and Tracy Hussell for being such great examiners too 🤓 🧪 #ImmunoSky @lydiabeckeriii.bsky.social
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Andrew S. MacDonald @profandrewmac.bsky.social · 02/12/2024
Flying trip back to @lydiabeckeriii.bsky.social and a chance to catch up with the Manchester team and to toast Stef and his new job in the Mann lab - good luck Stef!
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Andrew S. MacDonald @profandrewmac.bsky.social · 22/11/2024
That was fun - a research life fairly well summarised! 🧪
Cloud of words in various colors and sizes based on a Google Scholar profile. Some of the largest words include cells dendritic cell infection th2 responses helminth induction macrophage role mansoni response schistosoma vivo activation development inflammation CD4 function lung production human macrophages th1 type cd11c differentiation expression host immune
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Andrew S. MacDonald @profandrewmac.bsky.social · 20/11/2024
On my way to @uofglasgow.bsky.social to visit the School of #Infection and #Immunity and talk about our work on #mucosal responses during #schistosome infection - looking forward to it! #ImmunoSky 🪱 🧪
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Andrew S. MacDonald @profandrewmac.bsky.social · 30/10/2024
Really interesting talk from Calvin Tiengwe about Iron Transport and regulation in trypanosome parasites, as part of our IIIR seminar series 🧪
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Andrew S. MacDonald @profandrewmac.bsky.social · 24/10/2024
Lovely seminars from @kathelse.bsky.social and Franze Progatzny and Elaine Emmerson at the first Edinburgh Immunology Group event of the academic year today. Some really exciting immunology, from ‘wild’ #immunology to #glial cells via salivary gland #macrophages! #ImmunoSky 🧪
Picture of a seminar room with the speaker at the front and a screen showing a cartoon of a brain and some neuronal cells.
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Andrew S. MacDonald @profandrewmac.bsky.social · 22/10/2024
First office plant - hardy, resilient and a wee bit spiky…🤔 😂
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Andrew S. MacDonald @profandrewmac.bsky.social · 03/10/2024
Interesting new paper from @annaandrusaite.bsky.social - a new mechanism by which #microbiota derived #butyrate may control T cell responses, via inhibition of #cDC development and expression of costimulatory molecules. #ImmunoSky 🧪 www.mucosalimmunology.org/article/S193...
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Andrew S. MacDonald @profandrewmac.bsky.social · 18/09/2024
Just another normal, glorious, sunny September day at King’s Building in Edinburgh. Nothing unusual about this at all, oh no 😎 ☀️ 🧪
Ashworth Laboratories, University of Edinburgh, on a beautiful sunny September morning.King’s Buildings campus, University of Edinburgh, on a beautiful sunny September afternoon.
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Andrew S. MacDonald @profandrewmac.bsky.social · 13/09/2024
Leaving drinks @lydiabeckeriii.bsky.social today - so many great friends and colleagues that I’ll miss massively! But I’ve made them all promise to come visit in Edinburgh. And check the #cake, complete with #dendritic cell, #graphene, #schistosome infected snail & lab mouse, made by Helen Parker!
A lemon and blackberry sponge cake, decorated with a fondant dendritic cell, snail, mouse and graphene.A slice of lemon and blackberry sponge cake, 
 with a fondant snail.
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Andrew S. MacDonald @profandrewmac.bsky.social · 08/09/2024
A very useful infographic about #aspergillus from those nice folk over at the National Aspergillosis Centre in Manchester. #fungi #aspergillosis 🧪 #IDSky mft.nhs.uk/wythenshawe/...
An infographic explaining the range of disease that the fungus Aspergillus can cause.
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Andrew S. MacDonald @profandrewmac.bsky.social · 06/09/2024
Proud of my PhD student Olivia Shorthouse, presenting some of her work on how #schistosomes modify the #uterine immune profile and pathology, at the British Society of #Parasitology Autumn symposium this week 😊🧪🪱 #ImmunoSky #Immunology
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Andrew S. MacDonald @profandrewmac.bsky.social · 05/09/2024
Interesting paper from Rebecca Drummond and colleagues showing that depletion of interstitial lung macrophages that serve as a reservoir for fungal pathogens can help clear infections. 🧪 #ImmunoSky www.mucosalimmunology.org/article/S193...
Fluorescence immunohistochemistry/confocal microscopy of lung tissue samples from untreated or PLX5622-treated mice, showing CD169 in magenta, MHCII in green, CD11c in red and DAPI in blue, plus a merged image.
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Andrew S. MacDonald @profandrewmac.bsky.social · 04/09/2024
Another gorgeous morning in Edinburgh ☀️. Two days in a row, so clearly everyone is wrong about the cold and wet!
The King’s Buildings at the University of Edinburgh, on a beautiful sunny September morning, not a cloud in the sky.
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Andrew S. MacDonald @profandrewmac.bsky.social · 03/09/2024
Apart from when it’s not, of course 😏. This was yesterday. Reminded me of the wonderful Scottish word ‘dreich’ 🌧️
The Ashworth Laboratories, King’s Buildings, University of Edinburgh, on a drizzly dreich morning in September.
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Andrew S. MacDonald @profandrewmac.bsky.social · 03/09/2024
Well hello there Edinburgh 😊. It’s always sunny here!
The Ashworth Laboratories, King’s Buildings, University of Edinburgh, on a beautiful sunny morning in September.
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Andrew S. MacDonald @profandrewmac.bsky.social · 02/09/2024
Today is my first day back at the University of Edinburgh! Of course, after 11 wonderful years in Manchester, I’ll miss amazing colleagues & friends @lydiabeckeriii.bsky.social. But I can’t wait to reconnect with the brilliant Edinburgh community - exciting times ahead!
A view over the city of Edinburgh.
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