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Prateek GV

@prateekgv.bsky.social
30 followers 123 following 1 posts

ML/data scientist @Calico Life Sciences. Loyal fan of @Arsenal football club. Powered by research and coffee.

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Reposted by Prateek GV
Trends in Genetics @cp-trendsgenetics.bsky.social · 18/03/2026
"Beyond the baseline: mapping the context-specific regulatory landscape of disease" by Yoav Gilad and Alexis Battle authors.elsevier.com/sd/article/S...
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Reposted by Prateek GV
Tim Stearns @stearnslab.bsky.social · 21/03/2026
David Botstein was one of the giants of genetics and genomics, and my mentor, colleague and friend for more than 40 years. I’m sad that he is gone, but his larger-than-life persona comes through here. www.nytimes.com/2026/03/20/s...
nytimes.com
David Botstein, Gene-Mapping Pioneer, Dies at 83
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Reposted by Prateek GV
Jordy F. Botello @jbotello.bsky.social · 10/03/2026
Some molecular machines, like ribosomes, can persist for long periods of time in cells. Could molecular aging of ribosomes shape how proteins are made? In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10) www.biorxiv.org/content/10.6...
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Prateek GV @prateekgv.bsky.social · 12/03/2026
How to design antibodies? www.asimov.press/p/antibody-d...
asimov.press
How to Design Antibodies
A step-by-step guide to making de novo binders.
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Reposted by Prateek GV
Eric Topol @erictopol.bsky.social · 06/03/2026
The latest on sleep science and getting better quality sleep erictopol.substack.com/p/a-master-c...
erictopol.substack.com
A Master Class on Sleep
Professor Yo-El Ju, With plenty of practical tips
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Reposted by Prateek GV
Anil Raj @anilraj.bsky.social · 16/02/2026
Over a year ago, along with Gary Churchill at Jackson Labs, we explored the impact of dietary restriction on lifespan in one of the largest studies using 960 female Diversity Outbred mice. Caloric restriction and intermittent fasting both extended lifespan proportionally to the level of restriction.
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Reposted by Prateek GV
Aging Science News @agingbiology.bsky.social · 26/01/2026
Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice www.nature.com/articles/s41...
nature.com
Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice - Nature Communications
This study reveals that the ability to maintain a stable body weight predicts longevity in mice. By tracking weight dynamics throughout life, the authors identify genetic loci linked to body weight, e...
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Reposted by Prateek GV
Anil Raj @anilraj.bsky.social · 22/01/2026
Three years ago, we showed ~70% of lifespan variation in yeast traces to rDNA copy number. Ribosomal DNA, encoded as 5S and 45S subunits in hundreds of copies, vary substantially across humans. Does this copy number variation, and sequence variation within these paralogs, matter for humans?
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Reposted by Prateek GV
eLife @elife.bsky.social · 14/06/2025
🌍 Birds have the highest blood glucose levels of any vertebrate group. So, how do birds resist the harmful effects of high blood sugar and glycation?
buff.ly
A bird’s sweet deal
Analysis of 88 bird species reveals that those with higher blood glucose levels appear to be able to resist one of the harmful effects of glucose.
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Reposted by Prateek GV
Nature Microbiology @natmicrobiol.nature.com · 31/03/2025
OUT NOW: Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice #microsky #microbiomesky 🧪 www.nature.com/articles/s41...
nature.com
Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice - Nature Microbiology
Using a cohort of nearly 1,000 genetically diverse mice undergoing dietary restriction over the lifespan, the authors reveal numerous insights into the interactions between the gut microbiome, host ge...
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Reposted by Prateek GV
allen institute @alleninstitute.org · 01/01/2025
New brain aging study is out today in Nature The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. 🧵 #studyBRAIN
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Reposted by Prateek GV
Francis Bach @bachfrancis.bsky.social · 21/12/2024
My book is (at last) out, just in time for Christmas! A blog post to celebrate and present it: francisbach.com/my-book-is-o...
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Reposted by Prateek GV
BrunetLab @brunetlab.bsky.social · 18/12/2024
Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵
rdcu.be
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
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Reposted by Prateek GV
Jonathan Pritchard @jkpritch.bsky.social · 17/12/2024
If you do GWAS or rare variant association studies, check out this short thread on the concept of SPECIFICITY, and why it is a major determinant of what we find:
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Reposted by Prateek GV
Nature Portfolio @natureportfolio.nature.com · 20/11/2024
A collection published across Nature Portfolio journals presents early draft maps of cells in the human body from the Human Cell Atlas initiative. The research leverages new data and analytical tools to aid our understanding of human health and disease at a cellular level. 🧪
go.nature.com
The Human Cell Atlas: towards a first draft atlas
In a collection of research articles and related content, the Human Cell Atlas consortium presents tools, data and ideas towards the generation of their first draft atlas of cells in the human body.
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