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Pranvera Sadiku

@pranvera.bsky.social
250 followers 344 following 3 posts

Postdoc in @walmsley-lab.bsky.social @edinuni-irr.bsky.social interested in neutrophils and metabolism.

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Reposted by Pranvera Sadiku
Alejandro Brenes @ajbrenes.com · 15/12/2025
Excited to share our work at @natcomms.nature.com We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq. SCP will revolutionise immunology, this is just the start
nature.com
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma - Nature Communications
Neutrophils infiltrate glioblastomas with the capacity to engage pro/anti tumoural responses. Here the authors developed proteomic workflows to stratify neutrophil heterogeneity by function. This work...
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Pranvera Sadiku @pranvera.bsky.social · 28/10/2025
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
rdcu.be
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...
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Reposted by Pranvera Sadiku
bioRxiv Immunology @biorxiv-immuno.bsky.social · 27/07/2025
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma www.biorxiv.org/content/10.1101/202…
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Reposted by Pranvera Sadiku
Jose M. Adrover @adrover.bsky.social · 17/07/2025
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...
nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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Reposted by Pranvera Sadiku
Fendt Lab @fendtlab.bsky.social · 01/01/2025
Did you ever wonder why metastatic cancers often spread to the lungs? Amazing research from @ginevradoglioni.bsky.social! Many thanks to all collaborators, funders and patients. Wishing you all an enjoyable read and a happy new year and Ginevra a great next endeavor @salkinstitute.bsky.social
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Reposted by Pranvera Sadiku
Ivan Zanoni @lozanzi.bsky.social · 08/01/2025
#InterferonPower! Khan Tran Divanghai &co show @natimmunol.bsky.social that systemic fungal b-glucan administration potentates granulopoieis via type I IFNs (not IL1!) driving IL10-producing neutrophils that protect against lung influenza A virus infection increasing immune tolerance, not resistance
nature.com
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus - Nature Immunology
Divangahi and colleagues report that β-glucan pretreatment before influenza A virus challenge can increase survival by inducing long-term reprogramming of neutrophils, promoting disease tolerance irre...
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