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Manuel A. S-G

@mas-g.bsky.social
82 followers 154 following 2 posts

Post-doc at the University of Edinburgh. Neuts and hypoxia it is!

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Reposted by Manuel A. S-G
Nature Reviews Immunology @natrevimmunol.nature.com · 05/11/2025
Highlight of @natimmunol.nature.com paper by @mas-g.bsky.social @walmsley-lab.bsky.social showing epigenetic reprogramming of neutrophils in response to hypoxia to reduce lung tissue damage #immunosky
nature.com
Hypoxia-induced epigenetic reprogramming of neutrophil progenitors - Nature Reviews Immunology
Sanchez-Garcia et al. report that systemic hypoxia-induced epigenetic reprogramming of neutrophil progenitors in the bone marrow reduces their effector function to limit lung tissue damage.
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Manuel A. S-G @mas-g.bsky.social · 28/10/2025
Thrilled to see online our latest paper on hypoxia and neutrophil memory #Huge_team_effort @walmsley-lab.bsky.social in @edinuni-irr.bsky.social. Huge thanks to all our collaborators and blood donors. rdcu.be/eM5MT
rdcu.be
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...
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Reposted by Manuel A. S-G
Institute for Regeneration and Repair @edinuni-irr.bsky.social · 28/10/2025
How low blood oxygen can affect your body's immune defences 🛡️ A new study reveals that neutrophils have their genetic material modified by hypoxia and how the BCG vaccine may reverse this immune response. Our article: edin.ac/49nENu4 Nature Immunology paper: www.nature.com/articles/s41...
Device that measures blood oxygen levels on the finger of an elderly individual
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Reposted by Manuel A. S-G
Pranvera Sadiku @pranvera.bsky.social · 28/10/2025
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
rdcu.be
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...
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Reposted by Manuel A. S-G
Alejandro Brenes @ajbrenes.com · 28/10/2025
#Neutrophils are short lived cells, yet in ARDS display long term changes, with impaired neutrophil functions even after 6 months. How can they undergo long term reprogramming? this is what @mas-g.bsky.social answered, mapping changes to neut. progenitors. @walmsley-lab.bsky.social #immunosky
nature.com
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity - Nature Immunology
Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in long-term impairment of subse...
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Reposted by Manuel A. S-G
Aida Rodrigo @aidarodrigo.bsky.social · 23/03/2025
🚨 Heads-up: a little over a week to apply for this exciting postdoc opportunity in Edinburgh @edinuni-irr.bsky.social! 🚨 I will be in Liverpool for #biologists100. Happy to chat about the position, our research, setting up a lab, spiny mice, axolotls, and whatnot!
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