Reposted by Pranavathiyani GNobel Prize @nobelprize.org · 18hBREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.” 16973477
Pranavathiyani G @pranavathiyani.bsky.social · 04/10/2026Can you name the women who have won a science Nobel prize? Take @nature.com quiz on female @Nobel laureates in physics, chemistry or physiology or medicine. @nobelprize.org www.nature.com/articles/d41... #NobelPrizeWeek2026nature.comCan you name the women who have won a science Nobel prize?Take Nature’s quiz on female Nobel laureates in physics, chemistry or physiology or medicine. 010
Reposted by Pranavathiyani GNature Reviews Drug Discovery @natrevdrugdiscov.nature.com · 20/04/2026Target identification and assessment in the era of AI rdcu.be/fep9Z www.nature.com/articles/s41... This new Review analyses advances in applying AI-driven approaches for therapeutic target exploration, and discusses how to address challenges and limitations in the field 031
Reposted by Pranavathiyani GGalaxy Project @galaxyproject.bsky.social · 18/03/2026Registration is now OPEN for the 2026 Galaxy Training Academy! A free, global week of hands-on training in: 🧬 Proteomics | 🧩 Assembly | 🧫 Transcriptomics 🔬 Single cell | 🌍 Climate | 🤖 Machine learning + more 🗓 May 18–22 Learn more and register here: gxy.io/GTA2026-info 054
Reposted by Pranavathiyani GEMBL-EBI @ebi.embl.org · 26/02/2026📢 We want your feedback on our new pilot project for sharing AI models in life science research. Finding, reusing and citing machine learning models remains a major challenge in the life sciences. BioAIrepo is here to help. www.ebi.ac.uk/about/news/t...ebi.ac.ukBioAIrepo: EMBL-EBI’s hub for life science AI modelsNew EMBL-EBI repository helps researchers share and reuse machine learning models trained on life science data. 1168
Reposted by Pranavathiyani GProtein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 21/10/2025AlphaFold DB v6 (synced with UniProt 2025_03) is live! Here are the details: Totals v4 → v6: 241,070,489 entries. Since v4: +65,711,653 added, 39,324,993 removed, 276,539 changed (in sequence), 175,082,297 unchanged (metadata refresh, relabelled v6). Details 👇 194
Reposted by Pranavathiyani GPosit @posit.co · 17/09/2025📣 HUGE ANNOUNCEMENT! Drum roll please 🥁🥁🥁🥁🥁🥁🥁 Introducing Positron, a free code editor built specifically for data science. Learn more about what you can do with Positron: posit.co/blog/positro... 2527
Reposted by Pranavathiyani GFEMS @femsmicro.org · 17/09/2025For #InternationalMicroorganismDay, we asked our FEMS MICRO 2025 Keynote Speakers and FEMS Journal Editors "'What is your favourite microbe?'' With delightful answers, ranging over many microbes and personal stories, this was the perfect way to celebrate IMD 2025! #MicroSky youtu.be/oEJsWNJCtBwyoutu.beFavourite Microbes for International Microorganism Day 2025YouTube video by FEMS Microbiology 074
Reposted by Pranavathiyani GAntimicrobial resistance #AMR @antimicrobial.bsky.social · 13/09/2025Today on World Sepsis Day, neonatal sepsis remains a major killer, taking over 400,000 newborn lives each year, driven by weak immunity, delayed care, and #AMR. Strengthening hygiene, diagnostics, and timely treatment is crucial to closing the survival gap. www.financialexpress.com/life/health/...financialexpress.comWorld Sepsis Day 2025: 400,000 babies die each year from this silent infection—Can it be stopped?World Sepsis Day 2025: Sepsis is a silent infection that takes 400,000 newborn lives every year. Weak immunity, delayed treatment, and drug resistance make it harder to save babies. 01913
Pranavathiyani G @pranavathiyani.bsky.social · 11/09/2025Ten simple rules for navigating #AI in #Science @plos.org 010
Reposted by Pranavathiyani GProtein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 11/09/2025🧪 We're beta testing – and we want your thoughts! Try the new PDBe-KB Complex pages and let us know: 🔸 What’s working? 🔸 What’s confusing? 🔸 What features are lacking 💬 Feedback form: tinyurl.com/pdbekb-compl... #PDBeKB #Complexes #Bioinformatics #StructuralBiology #Science 064
Pranavathiyani G @pranavathiyani.bsky.social · 30/07/2025Virtual Lab #AI www.czbiohub.org/news/with-no...czbiohub.orgAI-built ‘scientists’ get the job done quicklyIn Virtual Lab project, CZ Biohub San Francisco researchers and collaborators assemble team of interdisciplinary AI agents that can solve complex research questions 030
Reposted by Pranavathiyani GJavier Santoyo @jsantoyo.bsky.social · 23/07/2025PhyloScape: interactive and scalable visualization platform for phylogenetic trees. r#PhylogeneticTees #Visualization #Bioinformatics #BMCbioinformatics bmcbioinformatics.biomedcentral.com/articles/10.... 041
Reposted by Pranavathiyani GStephen Turner @stephenturner.us · 22/07/2025Genomic reproducibility in the bioinformatics era genomebiology.biomedcentral.com/articles/10.... 🧬🖥️ 153
Reposted by Pranavathiyani GStephen Turner @stephenturner.us · 11/07/2025Exploring R and Rust in Bioinformatics - online developer forum blog.bioconductor.org/posts/2025-0... #Rstats #rustlang 072
Pranavathiyani G @pranavathiyani.bsky.social · 25/06/2025#AlphaGenome: #AI for better understanding the #genome deepmind.google/discover/blo...deepmind.googleAlphaGenome: AI for better understanding the genomeIntroducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API. 052
Pranavathiyani G @pranavathiyani.bsky.social · 10/05/2025Tissue specific protein-protein associations #atlas #ppi #disessenature.comA tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature BiotechnologyProtein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource. 000
Pranavathiyani G @pranavathiyani.bsky.social · 09/05/2025#Candida auris - emerging pathogen of #UTIjournals.plos.orgCandida auris is emerging as a prevalent urinary pathogenUrinary tract infections (UTIs) are one of the most common infections, with a subgroup of these infections, catheter-associated UTIs (CAUTIs), accounting for 40% of nosocomial infections. While the ma... 000
Reposted by Pranavathiyani GZoe Anne Dyson @msmicrobiocode.bsky.social · 09/05/2025🧬 Out today 🧬 - our TyphiNET #AMR surveillance dashboard for #typhoid Use TyphiNET to view genome-derived data on global and national annual trends in AMR and circulating pathogen genotypes via any standard web browser. genomemedicine.biomedcentral.com/articles/10....genomemedicine.biomedcentral.comThe TyphiNET data visualisation dashboard: unlocking Salmonella Typhi genomics data to support public health - Genome MedicineBackground Salmonella enterica subspecies enterica serovar Typhi (abbreviated as ‘Typhi’) is the bacterial agent of typhoid fever. Effective antimicrobial therapy reduces complications and mortality; ... 2137
Pranavathiyani G @pranavathiyani.bsky.social · 23/04/2025#Programming for researchnature.comWhich programming language should I use? A guide for early-career researchersComputer scientists and bioinformaticians address four key questions to help rookie coders to make the right choice. 010
Pranavathiyani G @pranavathiyani.bsky.social · 11/03/2025Margaret Dayhoff! #Bioinformatics www.nature.com/articles/s43...nature.comCelebrating a pioneer in bioinformatics - Nature Computational ScienceIn honor of the 100th birthday of Margaret Dayhoff, we spotlight her footprint in the field of bioinformatics. 031
Reposted by Pranavathiyani GMartin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 20/01/2025Foldseek 10 with 4-27x (1-8 GPUs) faster search through MMseqs2-GPU. Faster ProstT5 protein search w/o structure prediction through multi-GPU/Apple Metal, new BFVD/BFMD databases and multimer clustering (preview). 💾 github.com/steineggerla... 📄 www.biorxiv.org/content/10.1... 🐍 available in bioconda 17824
Pranavathiyani G @pranavathiyani.bsky.social · 04/12/2024#KlebPhaCol www.biorxiv.org/content/10.1... #klebsiella #phagebiorxiv.orgKlebPhaCol: A community-driven resource for Klebsiella research identified a novel gut phage order associated with the human gutThe growing threat of multidrug-resistant Klebsiella pneumoniae, coupled with its role in gut colonisation, has intensified the search for new treatments, including bacteriophage therapy. Despite incr... 100
Pranavathiyani G @pranavathiyani.bsky.social · 03/12/2024Bacteria’s Stress Strategy: Slow Down to Avoid the Crowd www.the-scientist.com/bacteria-s-s... #bacteria #stress #simulationthe-scientist.comBacteria’s Stress Strategy: Slow Down to Avoid the CrowdComputer simulations highlight how bacteria slow their growth to avoid overcrowding, a behavior that may inform pathogen control. 000
Pranavathiyani G @pranavathiyani.bsky.social · 02/12/2024www.ipd.uw.edu/2024/11/intr... #peptidedesign #diffusionipd.uw.eduIntroducing RFpeptides - Institute for Protein DesignGenerative AI based on RFdiffusion designs cyclic peptides with atomic accuracy. 010
Pranavathiyani G @pranavathiyani.bsky.social · 30/11/2024www.nature.com/articles/d41... #longevity #agingnature.comWhat’s the secret to living to 100? Centenarian stem cells could offer cluesA bank of cells from people more than 100 years old gives scientists a new resource for studying longevity. 000
Pranavathiyani G @pranavathiyani.bsky.social · 29/11/2024Language Models for Molecular Dynamics www.biorxiv.org/content/10.1... #languagemodel #moleculardynamicsbiorxiv.orgLanguage Models for Molecular DynamicsMolecular Dynamics (MD) simulations provide accurate descriptions of the motions of molecular systems, yet their computational demands pose significant challenges in applications in molecular biology ... 000
Reposted by Pranavathiyani GbioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 29/11/2024EasyPubPlot: a shiny web application for rapid omics data exploration and visualization www.biorxiv.org/content/10.1101/202… biorxiv.orgEasyPubPlot: a shiny web application for rapid omics data exploration and visualization https://www.biorxiv.org/content/10.1101/2024.11.26.625339v1 Computational toolkits for data exploration and visualization from widely used omics platforms often 021
Reposted by Pranavathiyani GGabriele Corso @gcorso.bsky.social · 28/11/2024We’re excited to release a major update to the Boltz repo: v0.3.0. This release contains several important new features, including our confidence model and memory-efficient inference. Give it a try! github.com/jwohlwend/bo...github.comGitHub - jwohlwend/boltz: Official repository for the Boltz-1 biomolecular interaction modelOfficial repository for the Boltz-1 biomolecular interaction model - jwohlwend/boltz 27113
Reposted by Pranavathiyani GMilot Mirdita @milot.bsky.social · 27/11/2024MMseqs2 Release 16 Highlights: GPU-accelerated search📄, ORF or new 6-frame translated search modes, contig taxonomy always keeps the longest ORF, bug fixes (reduced memory and higher sensitivity) and relicensed as MIT 📄 biorxiv.org/content/10.1... 💾 mmseqs.com and 🐍Bioconda 🖥️🧬🧶 011443
Pranavathiyani G @pranavathiyani.bsky.social · 26/11/2024#NetworkCommons: bridging data, knowledge and methods to build and evaluate context-specific biological #networks www.biorxiv.org/content/10.1...biorxiv.orgNetworkCommons: bridging data, knowledge and methods to build and evaluate context-specific biological networksSummary: We present NetworkCommons, a platform for integrating prior knowledge, omics data, and network inference methods, facilitating their usage and evaluation. NetworkCommons aims to be an infrast... 100
Reposted by Pranavathiyani GCameron Thrash @jcamthrash.bsky.social · 19/11/2024UniProt: the Universal Protein Knowledgebase in 2025 academic.oup.com/nar/advance-... #jcampubsacademic.oup.comUniProt: the Universal Protein Knowledgebase in 2025Abstract. The aim of the UniProt Knowledgebase (UniProtKB; https://www.uniprot.org/) is to provide users with a comprehensive, high-quality and freely acce 0196
Pranavathiyani G @pranavathiyani.bsky.social · 23/11/2024#WhatIsMyGene: Back to the Basics of Gene Enrichment www.biorxiv.org/content/10.1... #enrichment #genesbiorxiv.orgWhatIsMyGene: Back to the Basics of Gene EnrichmentSince its inception over 20 years ago, gene enrichment has been largely associated with curated gene lists (e.g. GO) that are constructed to represent various biological concepts; the cell cycle, canc... 010
Pranavathiyani G @pranavathiyani.bsky.social · 22/11/2024#PanTax: Strain-level taxonomic classification of metagenomic data using #pangenome graphs www.biorxiv.org/content/10.1... #microbiome #metagenomics #taxonomybiorxiv.orgPanTax: Strain-level taxonomic classification of metagenomic data using pangenome graphsMicrobes are omnipresent, thriving in a range of habitats from oceans to soils and even within our gastrointestinal tracts. They play a vital role in maintaining ecological equilibrium and promoting t... 063
Reposted by Pranavathiyani GKourosh Kalantar-Zadeh @kouroshkalantar.bsky.social · 20/11/2024Your friends shape your microbiome — and so do their friends Analysis of nearly 2,000 people living in remote villages in Honduras reveals who’s spreading gut microorganisms to whom. www.nature.com/articles/d41... 082
Pranavathiyani G @pranavathiyani.bsky.social · 22/11/2024#Harmonizome 3.0: integrated knowledge about genes and proteins from diverse multi-omics resources academic.oup.com/nar/advance-... #knowledgegraph #multiomics #genes #data #llmacademic.oup.comHarmonizome 3.0: integrated knowledge about genes and proteins from diverse multi-omics resourcesAbstract. By processing and abstracting diverse omics datasets into associations between genes and their attributes, the Harmonizome database enables resea 000
Pranavathiyani G @pranavathiyani.bsky.social · 22/11/2024#Gaia: A Context-Aware #Sequence Search and Discovery Tool for Microbial #Proteins www.biorxiv.org/content/10.1... #languagemodel #llmbiorxiv.orgGaia: A Context-Aware Sequence Search and Discovery Tool for Microbial ProteinsProtein sequence similarity search is fundamental to genomics research, but current methods are typically not able to consider crucial genomic context information that can be indicative of protein fun... 000
Reposted by Pranavathiyani GbioRxivpreprint @biorxivpreprint.bsky.social · 21/11/2024CellBinDB: A Large-Scale Multimodal Annotated Dataset for Cell Segmentation with Benchmarking of Universal Models www.biorxiv.org/content/10.1101/202… biorxiv.orgCellBinDB: A Large-Scale Multimodal Annotated Dataset for Cell Segmentation with Benchmarking of Universal Models https://www.biorxiv.org/content/10.1101/2024.11.20.619750v1 In recent years, advances in cell segmentation techniques have played a critical role in the analysi 011
Pranavathiyani G @pranavathiyani.bsky.social · 21/11/2024What is the real value of #omics data? Enhancing #research outcomes and securing long-term data excellence academic.oup.com/nar/article/...academic.oup.comWhat is the real value of omics data? Enhancing research outcomes and securing long-term data excellenceAbstract. A wealth of high-throughput biological data, of which omics constitute a significant fraction, has been made publicly available in repositories o 011
Pranavathiyani G @pranavathiyani.bsky.social · 21/11/2024#AI-readiness for #Biomedical Data: Bridge2AI Recommendations www.biorxiv.org/content/10.1...biorxiv.orgAI-readiness for Biomedical Data: Bridge2AI RecommendationsBiomedical research and clinical practice are in the midst of a transition toward significantly increased use of artificial intelligence (AI) and machine learning (ML) methods. These advances promise ... 010
Pranavathiyani G @pranavathiyani.bsky.social · 21/11/2024Global ocean #microbiome catalogue: A gateway to unlock marine microbial resources and #ecosystem functions www.the-innovation.org/article/doi/...the-innovation.orgGlobal ocean microbiome catalogue: A gateway to unlock marine microbial resources and ecosystem functions 010
Pranavathiyani G @pranavathiyani.bsky.social · 21/11/2024#Boltz-1: Democratizing Biomolecular Interaction Modeling www.biorxiv.org/content/10.1... #biomolecules #interactionsbiorxiv.orgBoltz-1: Democratizing Biomolecular Interaction ModelingUnderstanding biomolecular interactions is fundamental to advancing fields like drug discovery and protein design. In this paper, we introduce Boltz-1, an open-source deep learning model incorporating... 010
Reposted by Pranavathiyani GLeo Zang @leozang.bsky.social · 21/11/2024Database updates -The Pfam protein families database: embracing AI/ML academic.oup.com/nar/advance-... - UniProt: the Universal Protein Knowledgebase in 2025 academic.oup.com/nar/advance-... - RASP v2.0: an updated atlas for RNA structure probing data academic.oup.com/nar/advance-...academic.oup.comUniProt: the Universal Protein Knowledgebase in 2025Abstract. The aim of the UniProt Knowledgebase (UniProtKB; https://www.uniprot.org/) is to provide users with a comprehensive, high-quality and freely acce 1163
Reposted by Pranavathiyani GKyle Tretina @allthingsapx.bsky.social · 19/11/2024If you're building AI models for drug discovery, you should check out the newly open-source #BioNeMo Framework: code: github.com/NVIDIA/bione... paper: arxiv.org/abs/2411.10548 docs: docs.nvidia.com/bionemo-fram... explainer: t.co/7MOamSChGNgithub.comGitHub - NVIDIA/bionemo-framework: BioNeMo Framework: For building and adapting AI models in drug discovery at scaleBioNeMo Framework: For building and adapting AI models in drug discovery at scale - NVIDIA/bionemo-framework 094
Reposted by Pranavathiyani GJavier Santoyo @jsantoyo.bsky.social · 19/11/2024APAtizer: a tool for alternative polyadenylation analysis of RNA-Seq data. #PolyA #AlternativePolyadenylation #RNAseq #Sequencing #Bioinformatics 🧬 🖥️ academic.oup.com/bioinformati...academic.oup.comAPAtizer: a tool for alternative polyadenylation analysis of RNA-Seq dataAbstractSummary. APAtizer is a tool designed to analyze alternative polyadenylation events on RNA-sequencing data. The tool handles different file formats, 081
Pranavathiyani G @pranavathiyani.bsky.social · 14/11/2024All about #Bioinformatics! go.bsky.app/ExYDQFv 360