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Shreeram 'Ram' Akilesh

@podocytes.bsky.social

388 followers 103 following 6 posts

Associate Professor, Renal Pathologist and Kidney Genomics/Spatial -omics Researcher. Posts represent my opinions not medical advice. #renalpath #NephSky. faculty.washington.edu/shreeram

Posts Replies Media

Shreeram 'Ram' Akilesh @podocytes.bsky.social · 30/04/2025

Our latest work studying the reproducibility and sensitivity tradeoffs in spatial transcriptomics. All done with clinically sourced tissues as a foundation for future diagnostics - collab with @kelsmithpath.bsky.social : doi.org/10.1016/j.la...

doi.org

Redirecting

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Shreeram 'Ram' Akilesh @podocytes.bsky.social · 25/02/2025

We learn a lot from our patient's kidney biopsies. In collaboration with Astrid Weins (Brigham), we identified 2 patients with defects in peripheral immune tolerance (no Tregs, ICI tx for cancer). Both developed anti-nephrin antibody-associated minimal change disease: karger.com/gdz/article/...

karger.com

Genetic and Iatrogenic Defects in Peripheral Tolerance Associated with Anti-Nephrin Antibody-Associated Minimal Change Disease

Abstract. Introduction: Minimal change disease (MCD) is a common cause of nephrotic syndrome in children and adults. Immune dysregulation is a contributor, but the relative roles of individual compone...

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Shreeram 'Ram' Akilesh @podocytes.bsky.social · 27/01/2025

A little mosaic project of my favorite cell 🐙

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Shreeram 'Ram' Akilesh @podocytes.bsky.social · 25/01/2025

Oooh pretty!! Many thanks to @susanallison.bsky.social and the entire staff of @natrevneph.bsky.social for helping @oligopain.bsky.social and me with this review. LOVE ❤️ the cover!!

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Shreeram 'Ram' Akilesh @podocytes.bsky.social · 22/11/2024

These starter packs are amazing. Thank you! 🫘🔬

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Reposted by Shreeram 'Ram' Akilesh

Rachel Lennon @rachellennon.bsky.social · 21/11/2024

Delighted to share our latest paper: "The glomerular circadian clock temporally regulates basement membrane dynamics and the podocyte glucocorticoid response" Expertly led by Rebecca Preston & in collaboration with clock superstar Qing Jun Meng pubmed.ncbi.nlm.nih.gov/39515644/ Key findings 👇👇

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Shreeram 'Ram' Akilesh @podocytes.bsky.social · 21/11/2024

Somewhere over the kidney rainbow... 🫘🌈 #NephSky #renalpath

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Reposted by Shreeram 'Ram' Akilesh

Brian Beliveau @oligopain.bsky.social · 15/11/2024

The pSABER paper is now online! pSABER is a new method for amplifying in situ hybridization signals This work was driven by Sahar Attar and co-led by Ram Akliesh ([at] podocytes on the other app) with help from @shechnerlab.bsky.social @dschweppe.bsky.social doi.org/10.1038/s415... 🧵 1/12

doi.org

Efficient and highly amplified imaging of nucleic acid targets in cellular and histopathological samples with pSABER - Nature Methods

pSABER combines the power of signal amplification by exchange reaction (SABER) with the deposition of fluorescent or colorimetric substrates by horseradish peroxidase to enable enhanced signals for in...

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