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Paul Madley-Dowd

@pmadleydowd.bsky.social
112 followers 118 following 36 posts

Research Fellow in Medical Statistics and Health Data Science at the University of Bristol

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Reposted by Paul Madley-Dowd
NIHR Biomedical Research Centre: Bristol @bristolbrc.bsky.social · 04/03/2026
🛠️New tool to help statisticians decide how to handle missing study data. 🎯Multiple imputation (MI) is where missing values are filled using stats techniques. The tool uses directed acyclic graphs to help decide whether MI will lead to misleading results. www.bristolbrc.nihr.ac.uk/improving-ho...
bristolbrc.nihr.ac.uk
Improving how missing data is handled in studies - Bristol Biomedical Research Centre
A new tool to help statisticians decide how to handle missing data in studies has been published by Bristol Biomedical Research Centre (BRC) researchers. In health research, it’s common to have missin...
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Reposted by Paul Madley-Dowd
NIHR Biomedical Research Centre: Bristol @bristolbrc.bsky.social · 26/02/2026
🆕 New project! Can we improve autistic people’s health by changing the medicines we prescribe?💊 ❓Is over-prescribing or under-prescribing some types of medicine causing health problems for people with #autism? 👉 bristolbrc.nihr.ac.uk/can-we-impro... @draipsych.bsky.social
bristolbrc.nihr.ac.uk
Can we improve autistic people’s health by changing the medicines we prescribe? - Bristol Biomedical Research Centre
Autistic people often have more health problems and a shorter life expectancy than non-autistic people. Healthcare differences may be a reason for this. For example, medicines that alter mood and brai...
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Reposted by Paul Madley-Dowd
Eric Topol @erictopol.bsky.social · 18/02/2026
In people age 50+, the Covid booster halved hospitalization and deaths. Waning of benefit after 3-6 months For the mRNA BA.1 booster vs no shot after initial vaccination www.sciencedirect.com/science/arti...
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Paul Madley-Dowd @pmadleydowd.bsky.social · 19/02/2026
Latest paper published in Vaccine : doi.org/10.1016/j.va...
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Reposted by Paul Madley-Dowd
Michel Nivard @michelnivard.bsky.social · 22/01/2026
Grace Power, @mendelrandom.bsky.social and others (not me!) takes a plausible causal FX of BMI on breast cancer, and narrow down *when* that effect plays out. They find the effects of later BMI on breast cancer are steeply attenuated when conditioned on early BMI. www.science.org/doi/10.1126/...
science.org
Lifecourse genome-wide association study meta-analysis refines the critical life stages for adiposity’s influence on breast cancer risk
Improving knowledge of adiposity’s genetic architecture across the lifecourse refines insights into its role in breast cancer.
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Reposted by Paul Madley-Dowd
Ian Hussey @ianhussey.mmmdata.io · 02/12/2025
Works the other way around too. “If I was Jonathan Haidt, how would I destroy the next generation?”
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Paul Madley-Dowd @pmadleydowd.bsky.social · 26/11/2025
Have you ever tried to implement multiple imputation with several incomplete variables? How do you know whether MI will be valid for your data? We have just published an easy to use algorithm using modifications to DAGs (now they're colourful) to aid decision making with MI doi.org/10.1093/aje/...
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Reposted by Paul Madley-Dowd
Viktor H. Ahlqvist @ahlqvistviktor.bsky.social · 24/09/2025
theconversation.com/paracetamol-...
theconversation.com
Paracetamol use during pregnancy not linked to autism, our study of 2.5 million children shows
Our research provides strong evidence against the concerning claims made recently by US president Donald Trump.
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Reposted by Paul Madley-Dowd
Adam Kucharski @adamjkucharski.bsky.social · 13/09/2025
When can a 10% improvement be worse than a 5% one? New post on vibe coding and 'volatility tax': kucharski.substack.com/p/the-hidden...
kucharski.substack.com
Vibe coding and 'volatility tax'
The value of predictable improvement
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Paul Madley-Dowd @pmadleydowd.bsky.social · 03/09/2025
Does anyone have any thoughts on digital twins in clinical trials or in-silico trials?
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Reposted by Paul Madley-Dowd
Margarita Moreno-Betancur @margaritamb.bsky.social · 10/07/2025
1/ NEW R PACKAGE! For estimating the impact of potential interventions on multiple mediators in countering exposure effects (led by @cttc101.bsky.social) - Paper👉 tinyurl.com/ye26jsps - Package👉 tinyurl.com/yuh4kens Thread shows published examples of how the method can be used! #EpiSky #CausalSky
tinyurl.com
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Reposted by Paul Madley-Dowd
Venexia Walker @venexia.bsky.social · 04/07/2025
🚨 Funded PhD opportunity 🚨 Work with large-scale electronic health record data from #OpenSAFELY to optimise vaccine effectiveness estimation for respiratory viruses. Apply here 👉 www.findaphd.com/phds/project...
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Reposted by Paul Madley-Dowd
Viktor H. Ahlqvist @ahlqvistviktor.bsky.social · 17/05/2025
For those of you using sibling analysis, perhaps you'll find this useful 🥳: www.medrxiv.org/content/10.1...
medrxiv.org
Moving beyond risk ratios in sibling analysis: estimating clinically useful measures from family-based analysis
Objective: Findings from family-based analyses, such as sibling comparisons, are often reported using only odds ratios or hazard ratios. We demonstrate how this can be improved upon by applying the ma...
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Reposted by Paul Madley-Dowd
Viktor H. Ahlqvist @ahlqvistviktor.bsky.social · 27/03/2025
Fantastic news! This is entirely attributable to all my colleagues—everyone from mentors to students—who have made this possible🎉🎉 news.ki.se/safer-medica...
news.ki.se
Safer medications for pregnant women and children
Viktor H. Ahlqvist, postdoc at the Institute of Environmental Medicine (IMM), receives 3,000,000 SEK in a Postdoctoral Grant from the Swedish Society for Medical Research (SSMF) for the project “Advan...
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Reposted by Paul Madley-Dowd
Lorenzo Fabbri @epilorenzo.bsky.social · 24/03/2025
It’s my understanding that with the parametric g-formula you use the outcome model to predict the outcome for each subject, independently of whether they are censored. And you take its mean considering ALL N subjects. If the pot. outcome has some NA, I’d still sum and divide by N. Stupid question:
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Reposted by Paul Madley-Dowd
Suzie Cro @suziecro.bsky.social · 18/03/2025
New publication led by @proflouisemarston.bsky.social using multiple imputation to target a hypothetical estimand in a pandemic restriction-free world for a trial in schizophrenia - demonstrating the potential impact of the pandemic on the trial results
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Paul Madley-Dowd @pmadleydowd.bsky.social · 19/02/2025
Final version published so time to talk about it: doi.org/10.1093/aje/... When using multiple imputation to account for missing data we often use auxiliary variables (variables included in the imputation model but not the analysis model) to 1) reduce bias and 2) improve statistical efficiency.
doi.org
Analyses using multiple imputation need to consider missing data in auxiliary variables
Abstract. Auxiliary variables are used in multiple imputation (MI) to reduce bias and increase efficiency. These variables may often themselves be incomple
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Paul Madley-Dowd @pmadleydowd.bsky.social · 21/11/2024
In our latest work we investigated the effect of antiseizure medication prescribing/dispensation in pregnancy on offspring neurodevelopmental outcomes using over 3 million pregnancies from the UK and Sweden. Article out now in Nature Comms: nature.com/articles/s41...
nature.com
Antiseizure medication use during pregnancy and children’s neurodevelopmental outcomes - Nature Communications
Some antiseizure medications including valporate are associated with neurodevelopmental conditions in children exposed in utero but evidence is less clear for other drugs. Here the authors investigate...
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Paul Madley-Dowd @pmadleydowd.bsky.social · 07/10/2024
We are running our short course on Advanced Multiple Imputation Methods to Deal with Missing data this December (5th and 6th). link for further info: tinyurl.com/ybu982ru
tinyurl.com
Advanced Multiple Imputation Methods to Deal with Missing Data
Multiple imputation is a principled approach to account for missing data in analyses where valid results depends on careful construction of the imputation model. The potential for misspecification of ...
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