Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Bar et al. show that neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.

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The Kapahi lab seeks postdocs to lead innovative projects exploring how circadian clocks & nutrient-responsive pathways influence eye & neuronal degeneration.

This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental factors affecting circadian rhythms in metabolic studies in rodents.

Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to p...

Kenny and Scharenberg et al. provide a broad overview of the fundamental aspects of choline metabolism and cellular handling, and how it impacts physiology and pathology.

Buck scientists fight the sugary chemistry of aging The same chemical reaction that makes a piece of freshly toasted bread delicious also happens in our bodies, with far less appetizing consequences. ...

Two leaders removed by Trump administration had hoped to stay at agency as in-house investigators

New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.

The projections, sent to lawmakers on Tuesday, highlight the sweeping consequences of a lapse in federal funding.

Reproductive timing can accelerate aging and disease

Bar et al. show that neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.

In addition to a new approach in Alzheimer’s research, study from Buck Institute could explain why GLP-1 drugs show promise against dementia.

Survey of hundreds of scientists’ work suggests that cutting off funding disrupts focus and reduces the novelty of research.

Glycation is a class of modifications arising from non-enzymatic reactions of reducing sugars with proteins, lipids, and/or DNA, generating advanced glycation end-products (AGEs). AGEs are linked to m...

Aims/hypothesis Epidemiological studies indicate that type 2 diabetes increases the risk for Alzheimer’s disease. Alterations in cerebral metabolism have been proposed as a potential mechanism underly...

Opportunity for LSI PHD studentship – starting in September 2025 or January 2026 PhD Studentship applications will open on 1st...

Much of the Trump administration’s agenda for research is laid out in the 900-plus-page blueprint. Nature read it so you don’t have to.

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