Jumbo phages are bacterial viruses with large genomes, oversized icosahedral capsids and complex tail architectures. Here, the authors use cryo-EM to provide a detailed structural analysis of jumbo ph...

Morgan et al. show that a phage-encoded protein functions as an antitoxin to counter DarTG2-mediated phage defense. They further explore the interplay between this anti-defense protein, the phage nucleus replication compartment, which encloses chimallivirus genomes, and the DarTG2 phage defense system.

Primary Work Address: 418 E 71st St #21, New York, NY, 10021 Current HHMI Employees, click here to apply via your Workday account. About the role: The Reck-Peterson lab studies the molecular mechanism...

Klebsiella host strains infected with telomere phages can grow to be the dominant lineage in mixed populations.

Latency is a common strategy in a wide range of viral lineages, but its prevalence in giant viruses remains unknown. Here we describe a 617 kbp integrated giant viral element in the model green alga C...

The pre-nuclear stage of Chimalliviridae infection and whether the phage nucleus is essential have remained mysterious. Armbruster and Rani et al. demonstrate that the phage nucleus is required for ph...

This study uncovers a highly conserved jumbo phage protein, Imp1, that possesses multiple interfaces to license protein import into a proteinaceous nucleus-like compartment, using a genetic selection ...

CHOC infectious disease expert Dr. Erlinda “Chulie” Ulloa makes history nationally with investigational medication.

UC San Diego School of Biological Sciences Professors Kimberly Cooper and Elizabeth Villa have been selected by the Pew Charitable Trusts as members of its 2024 class of Innovation Fund Investigators.

Bacteria possess a variety of operons with homology to eukaryotic ubiquitination pathways that encod

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...