iiinova — where your digital self keeps evolving

Paul Watton @paulwatton.bsky.social · 13/04/2025

This is the story of how the Pumpkin-headed buffoon in the Whitehouse, was completely outmanoeuvred and consequently forced to rescind his bullying imposition of trade #Tariffs I guarantee that it will make you smile. 😇 #dumbfuck #Capitulation #Humiliation deanblundell.substack.com/p/carneys-ch...

deanblundell.substack.com

Carney’s Checkmate: How Canada's Quiet Bond Play Forced Trump to Drop Tariffs

Carney, Japan And The EU proved America's Idiot Emperor Has No Clothes

Joey Politano🏳️‍🌈 @josephpolitano.bsky.social · 12/04/2025

Reposted by Paul Watton

Import Chinese battery: 145% tariff Import Chinese battery inside Chinese laptop: 20% tariff Import Chinese battery inside Vietnamese laptop: 0% tariff Fuckin brilliant. A+ work here team. I am so glad there are such smart people working on our trade policy.

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Reposted by Paul Watton

PrecisionLife @precisionlife.bsky.social · 28/02/2025

In addition to discovering and reproducing detailed long COVID genetic associations for the first time, PrecisionLife researchers were also the first to identify genetic risk factors for ME/CFS. To learn more about our research into long COVID and ME/CFS, visit precisionlife.com/longcovid-me

precisionlife.com

Unraveling the Biological Drivers of ME and Long COVID | PrecisionLife

We have identified different genetic mechanisms causing ME/CFS and Long COVID and used this to stratify patients. Learn more about our research.

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Reposted by Paul Watton

PrecisionLife @precisionlife.bsky.social · 07/03/2025

Last week we shared a significant advancement in our understanding of long COVID and its implications for precision medicine. This breakthrough exemplifies our commitment to driving precision medicine in complex chronic diseases, offering hope to billions affected worldwide. #PrecisionMedicine

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Paul Watton @paulwatton.bsky.social · 04/04/2025

Epigenetic "reprogramming" of immune cells by Epstein Barr Virus is probably what initiates the cascade of events which culminates in the disease known as #MEcfs Even after decades of neglecting Patients, the Medical Profession are far too slow to wake up to this reality app.box.com/s/a0ya16d5h8...

Epigenetic alteration of cells of the immune system by Epstein Barr Virus infection.docx | Powered by Box

Paul Watton @paulwatton.bsky.social · 01/04/2025

The involvement of microRNAs in the pathogenesis of #MEcfs cannot be ignored. The altered expression of these Non-coding RNAs in ME/cfs patients has a profound impact on several bodily systems via their regulatory pathways. Here's my take on what we currently know: app.box.com/s/engwwo7me9...

The Evidence for the Role of Non-Coding RNAs in the Pathogenesis of MEcfs.docx | Powered by Box

Tom Kindlon @tomkindlon.bsky.social · 31/03/2025

Reposted by Paul Watton

Registration for online participation in the @mecfsresearch.bsky.social International ME/CFS Conference 2025 on 12-13 May 2025 is now open events.mecfs-research.org/en/events/co... Image is from the latest Science for ME weekly update #MEcfs #LongCovid

Germany
Registration for online participation in the International ME/CFS Conference 2025 on 12-13 May 2025 is now open. The conference will be centred on the care, research, and treatment of ME/CFS and post-COVID syndrome. It is funded and organised by the German ME/CFS Research Foundation and will take place as an online livestream broadcast from the Harnack House of the Max Planck Society in Berlin.

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Paul Watton @paulwatton.bsky.social · 28/03/2025

For decades, I've been (wrongly) led to believe that latent Herpes virus infections and Gilbert's Syndrome are both benign. It now transpires that both are potentially contributory factors in the pathogenesis of #MEcfs Here's my hypothesis: app.box.com/s/korv1z60yy... It now needs to be tested.

Is Gilberts Syndrome a co-factor or vulnerability modifier in the pathogenesis of ME-cfs..docx | Powered by Box

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Reposted by Paul Watton

southpaw @nycsouthpaw.bsky.social · 28/03/2025

An important assertion in this statement is that the flight to Louisiana occurred on Wednesday morning. The district court ordered that she not to be moved out of Massachusetts on Tuesday.

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Reposted by Paul Watton

Alice Roberts @profaliceroberts.bsky.social · 26/03/2025

I’m finding it very hard to understand the stance of the Royal Society here. Science is part of society, not separate from it, existing in some strange metaphysical bubble. I look across the Atlantic, aghast at the damage being done to science and scientists. www.theguardian.com/technology/2...

theguardian.com

Royal Society decides not to take disciplinary action against Elon Musk

Exclusive: Fellows argue Musk has violated code of conduct but council believes investigation ‘could do more harm than good’

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Paul Watton @paulwatton.bsky.social · 24/03/2025

For 30+ years, #MEcfs has been largely ignored, because researchers haven't had the tools to enable them to understand it. With the advent of VISOR-CyTOF, the full extent of the consequences of Herpesvirus infection on the cells of the immune system can now be explored. www.cell.com/cell-reports...

cell.com

Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors

George et al. profile viral sensor and restriction factor (VISOR) expression in tissues of people with HIV. Tissue- and subset-dependent VISOR expression was observed, with the highest expression with...

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Reposted by Paul Watton

Mehdi Hasan @mehdirhasan.bsky.social · 21/03/2025

This is what anti-Palestinian racism and dehumanization looks like.

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Reposted by Paul Watton

Isabella Cueto @isabellacueto.bsky.social · 19/03/2025

NEW: Cuts to Columbia University funding have shuttered a prominent research center into ME/CFS, a debilitating condition with no FDA-approved treatments. It's a gut punch to a community that for years has been frustrated by a lack of funding. Developing... www.statnews.com/2025/03/19/m...

statnews.com

ME/CFS research program shuts down at Columbia after Trump cuts

ME/CFS, which affects millions of Americans, has few dedicated research centers. Now the one at Columbia has been shut down over Trump funding cuts.

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Reposted by Paul Watton

Carole Bruce @cabruce.bsky.social · 18/03/2025

Read #MEAction UK's response to today's statement from the UK government on changes to benefits.

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Paul Watton @paulwatton.bsky.social · 17/03/2025

1/3 Two papers on the subject of Epigenetic changes leading to T-Cell Exhaustion in #MEcfs Helps to nail down the pathogenesis of the disease: www.pnas.org/doi/abs/10.1... 1. Viral persistence initiates chronic immune stimulation. 2. Epigenetic changes lock immune cells into an exhausted state.

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Reposted by Paul Watton

Tessa Munt MP 🔶 @tessamunt.bsky.social · 12/03/2025

People with ME so want to be better and contribute to society. An ambitious and well-resourced Delivery Plan could make such a difference at relatively small cost. Thank you for asking me to join you in the call to #FundThePlan!

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Reposted by Paul Watton

Dmitry Grozoubinski @explaintrade.com · 08/03/2025

I know it's hopeless but I hope people in the UK remember the DOGE-woes the next time some populist douchecanoe claims that fixing Britain's problems is a simple matter of putting a businessman in charge, firing half the civil service, and lighting a regulatory bonfire. Shit's hard, yo.

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Paul Watton @paulwatton.bsky.social · 07/03/2025

"...... people with #MS appear to have a problem controlling #EBV from an immunological perspective. This is supported by work suggesting that EBV-specific cytotoxic T-cell responses are exhausted in MS, leading to poor virus control and greater MS disease activity." academic.oup.com/brain/articl...

academic.oup.com

EBV-specific T-cell responses are telling us something important about multiple sclerosis

This scientific commentary refers to ‘Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation’ by Schneider-Hoh

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Keep Trump out of Parliament

I just told Speaker Hoyle to keep Trump out of Parliament - will you do the same? actionstorm.org/petitions/du... #DumpTrump

actionstorm.org

Sign the Petition

Dr Steve Taylor @drstevetaylor.bsky.social · 04/03/2025

Reposted by Paul Watton

Geo-political events have recreated a feeling of dread I have seen play out before. I have a bad feeling about this! It’s a trap! This is how liberty dies…. with thunderous applause! Rebellions are built on hope!

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Reposted by Paul Watton

George Monbiot @georgemonbiot.bsky.social · 04/03/2025

Trump never had a peace plan for Ukraine. He had a plan for Ukraine's surrender, with a colonial resource grab. As Zelenskyy rightly refused it, or to cooperate in Trump's TV spectacular, the US has now cut Ukraine off. That's what blackmail looks like. That's what the world is up against.

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I created this image using BioRender. It's my attempt to depict Mitochondrial Dysfunction and the ROS-induced reversal of the Sodium /Calcium Exchanger in the Skeletal Muscle Cells of ME/cfs patients, as described by Klaus Wirth and Prof. Carmen Scheibenbogen. #Mitochondria #MEcfs #LongCovid

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Wałęsa condemns Trump treatment of Zelensky, likening it to communist interrogation

"Former Polish president and Nobel Peace Prize winner Lech Wałęsa has written a letter, co-signed by 38 other former political prisoners of Poland’s communist regime, to Donald Trump, condemning the US president’s treatment of Volodymyr Zelensky and Ukraine." notesfrompoland.com/2025/03/03/w...

notesfrompoland.com

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The newly published paper by Van Campenhout et al provides a useful review of the disease process, which serves to connect Metabolic Dysfunction and Immune Dysfunction in #MEcfs The list of scientific terms used in the paper (Table 1 in the paper) is reproduced here: app.box.com/s/ayhhf54rq5...