iiinova — where your digital self keeps evolving

Reposted by Paul Batty

Davide Seruggia @dseruggia.bsky.social · 26/02/2026

Happy to share our paper in collaboration with cancerbits.bsky.social. We used machine learning & ATAC-seq to refine erythroid differentiation protocols. Recipes for lineage differentiation are written on chromatin! @stanna-ccri.bsky.social @cemm.oeaw.ac.at

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Reposted by Paul Batty

Gerlich Lab @gerlichlab.bsky.social · 25/02/2026

1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰ Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs: www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by Paul Batty

Gerlich Lab @gerlichlab.bsky.social · 03/09/2025

1/ New preprint alert! In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis. 🔗 doi.org/10.1101/2025...

doi.org

An electrostatic repulsion model of centromere organisation

During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...

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Paul Batty @paulbatty1.bsky.social · 01/08/2025

I am pleased to share a new preprint from my postdoc in the @dseruggia.bsky.social lab. We discovered a structural dependency within the CORE module of the transcriptional coactivator SAGA, which regulates the stability of its histone acetyl transferase, KAT2A. www.biorxiv.org/content/10.1... 1/n

biorxiv.org

Disruption of the SAGA CORE triggers collateral degradation of KAT2A

The SAGA transcriptional co-activator complex regulates gene expression through histone acetylation at promoters, mediated by its histone acetyl transferase, KAT2A. While its structure and function ha...

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Reposted by Paul Batty

Anton Goloborodko @golobor.bsky.social · 15/07/2025

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/

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