iiinova — where your digital self keeps evolving

Reposted by Miha Modic

Gabrijela Dumbović @gabrijelad.bsky.social · 09/09/2026

Incredibly happy to share the first publication from our lab, now published in Nature Cell Biology! 🎉 How do cells coordinate RNA processing with nuclear organization and the cell cycle? www.nature.com/articles/s41...

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Reposted by Miha Modic

Sylvia Erhardt @erhardtlab.bsky.social · 24/10/2025

New Tuesday (Oct 28) in Heidelberg and online: kick off event of the Center for Synthetic Genomics: program and link to zoom: www.syn-gen.de/kick-off

syn-gen.de

Center Kick-Off Event | Center SynGen

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Miha Modic @paraspeckle.bsky.social · 08/09/2025

Beautiful mechanistic story, how QKI by bridging intronic motifs with U6 snRNA ensures inclusion of weak 5’ splice sites that are essential for building sarcomeres. Congrats @kurianlab.bsky.social and @evannostrandlab.bsky.social labs & all involved.

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Reposted by Miha Modic

Thomas Norman @normanlab.bsky.social · 06/08/2025

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

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Reposted by Miha Modic

Fusion Conferences @fusionconf.bsky.social · 17/07/2025

Explore RNA's role in epigenetics, DNA repair, transcription & genome organisation - directly with leaders from academia & industry at #GenReg26! Remaining talks to be filled from submissions - register & submit by 04 Sep 2025 to join us in Mexico. Speakers, details & registration➡️ bit.ly/46JQbze

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Reposted by Miha Modic

Dave Shechner @shechnerlab.bsky.social · 02/08/2025

I’m a bit late to the game here, but wanted to highlight this very clever technique from @paraspeckle.bsky.social’s group! Congrats to all authors!!

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Reposted by Miha Modic

Dave Shechner @shechnerlab.bsky.social · 02/08/2025

A day late but STILL IMPORTANT

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Reposted by Miha Modic

Lennart Hilbert @lennarthilbert.bsky.social · 29/07/2025

We are hiring! "Researcher in DNA-Based Information Processing Systems" (PhD or postdoc level). Co-supervision by Prof. Ralf Reussner (KIT computer science) and myself (biological systems). Combination of experiments and computational work. Please Apply / Repost! www.pse.kit.edu/english/karr...

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Miha Modic @paraspeckle.bsky.social · 23/07/2025

Exited to see SPIDR finally coming out! Congrats to Marko and the team on opening the next multiplexing RNA frontier 💥

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Miha Modic @paraspeckle.bsky.social · 23/07/2025

Thrilled to co-advertise this postdoc or PhD position with @erhardtlab.bsky.social! Join us, if RNP assembly on centromeres, RNA modifications, & bioinformatics are your thing. More info also on modiclab.org.

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Miha Modic @paraspeckle.bsky.social · 02/06/2025

New method drop: HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning. www.biorxiv.org/content/10.1...

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Miha Modic @paraspeckle.bsky.social · 24/05/2025

Harnessing the physical properties of peptides to predict their functionality and interactions. 💥

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Reposted by Miha Modic

Nacho Molina @molinalab.bsky.social · 19/05/2025

Time for a short thread! We developed HiddenFoot, a biophysics-inspired approach to decode single-molecule footprinting data and infer TF, nucleosome, and RNA Pol II binding profiles on individual DNA molecules. One molecule at a time! www.biorxiv.org/content/10.1... 1/6

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Miha Modic @paraspeckle.bsky.social · 18/04/2025

Thank you, Lennart! I'm very excited to join the newly founded Carl Zeiss Center for Synthetic Genomics and KIT with your lab nextdoor! Exciting times ahead!

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Reposted by Miha Modic

Karla Neugebauer @karlaneugebauer.bsky.social · 26/03/2025

I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...

authors.elsevier.com

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Reposted by Miha Modic

Itai Yanai @itaiyanai.bsky.social · 26/03/2025

The eternal question: should you focus on one problem for a very long time or is it more productive to bounce and work on many problems? David Baker says that both modes have been important in his career trajectory. podcasts.apple.com/us/podcast/n... @nightsciencepod.bsky.social

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Reposted by Miha Modic

Gabrijela Dumbović @gabrijelad.bsky.social · 25/03/2025

📣 Our lab is looking for a PhD student to join us in exploring RNA biology! Details in the announcement. Feel free to reach out with any questions—and please RT!

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Reposted by Miha Modic

Matthew Taliaferro @jmtali.bsky.social · 28/02/2025

Save the date for the next edition of this wonderful meeting. We look forward to seeing you in Portugal!!

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Reposted by Miha Modic

Rita Strack @ritastrack.bsky.social · 06/02/2025

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

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Miha Modic @paraspeckle.bsky.social · 06/02/2025

I am thrilled to share the first manuscript from my group on identifying sequence and structural features promoting the condensation of RNAs that are organising highly interconnected RNA networks, thereby expanding our understanding of higher-order transcriptome assemblage. shorturl.at/pmLIj #RNASky

biorxiv.org

Integrative profiling of condensation-prone RNAs during early development

Complex RNA–protein networks play a pivotal role in the formation of many types of biomolecular condensates. How intrinsic RNA features contribute to condensate formation however remains unclear. Here...

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