Sign in

Mrinmoy

@palmrinmoy.bsky.social
95 followers 112 following 18 posts

Postdoc @schuhlab.bsky.social. Former MSCA PhD fellow with @metorrespadilla.bsky.social. Oocytes, Embryos and Chromatin.

PostsRepliesMedia
Reposted by Mrinmoy
Schuh Lab @schuhlab.bsky.social · 15/09/2026
Huge congratulations to our PostDoc @palmrinmoy.bsky.social on receiving the Elisabeth Gateff Prize for his outstanding dissertation.🎉 His talk, “How DNA Self-Organizes in the Early Embryo,” and the award ceremony will be streamed online on 22 October at 3 pm! 🎥 www.gfgenetik.de/en/news/deta...
gfgenetik.de
Dr. Mrinmoy Pal receives this year’s Elisabeth Gateff Prize
44
041
Reposted by Mrinmoy
Schuh Lab @schuhlab.bsky.social · 13/08/2026
Why does female fertility decline with age – could we one day do something about it? Delighted to contribute to the new @artede.bsky.social documentary “Stecken wir in einer Eizellen-Krise?” featuring our research on why chromosomes become unstable in ageing eggs - and how to keep them stable.
121
Reposted by Mrinmoy
Schuh Lab @schuhlab.bsky.social · 16/07/2026
Last week, I had the great honour of being formally admitted as a Fellow of the @royalsociety.org & signing its historic Charter Book. Deeply grateful for this recognition of our work. None of this would've been possible without many wonderful lab members, colleagues & collaborators. ✨
161
Reposted by Mrinmoy
ME Torres-Padilla @metorrespadilla.bsky.social · 27/06/2026
In Formation - 4 artists - one goal: Art & Science Vernissage 5.07 at 17h00 @Muffatwerk
083
Reposted by Mrinmoy
Schuh Lab @schuhlab.bsky.social · 23/06/2026
Congratulations to our Postdoc @palmrinmoy.bsky.social on receiving the Helmholtz Munich Doctoral Researcher Award 2026 for his outstanding PhD research. We are proud to now have you in our Schuh lab. A well-deserved recognition! 🎉🌟 📷credits: @helmholtzmunich.bsky.social
072
Reposted by Mrinmoy
Schuh Lab @schuhlab.bsky.social · 27/05/2026
I am deeply honored to have been elected as a Foreign Member of the @royalsociety.org. Very grateful to all members of the lab, past & present. Their curiosity & commitment to science shaped the work in countless ways. It's been a privilege to work with them. www.mpinat.mpg.de/5261989/pr_2...
mpinat.mpg.de
Royal Society elects Melina Schuh as Fellow
Biochemist Melina Schuh elected Fellow of the Royal Society for groundbreaking research on egg cell development.
1174
Reposted by Mrinmoy
Schuh Lab @schuhlab.bsky.social · 21/05/2026
Many congratulations to our PostDoc @palmrinmoy.bsky.social on receiving the Best Poster Award at the @events.embl.org Practical Course “Ultrastructure Expansion Microscopy: From Cells to Tissue” last month! 🎉👏 A great achievement — very well deserved!
0142
Reposted by Mrinmoy
Schuh Lab @schuhlab.bsky.social · 08/05/2026
Grateful to receive the Pearse Prize from the @royalmicrosoc.bsky.social. A big thank you to my amazing team and collaborators — this is truly a shared recognition. 🌟 www.rms.org.uk/resource/dr-...
rms.org.uk
Dr Melina Schuh to receive RMS Pearse Prize
093
Reposted by Mrinmoy
ME Torres-Padilla @metorrespadilla.bsky.social · 20/03/2026
Just out! 👀 for TFs that regulate TEs.Clara's work with @tamas-schauer.bsky.social @marliesoomen.bsky.social @palmrinmoy.bsky.social and bluesky-less lab members 🌎 identifies TBP as a regulator of specific ERVL class: MaLRs in 🐭embryos -as always -feedback welcome👍 link.springer.com/article/10.1...
13410
Mrinmoy @palmrinmoy.bsky.social · 14/07/2025
Defended my PhD last week! It’s been an incredible journey filled with challenges and exciting science. I'm deeply grateful to everyone who was part of it -especially @metorrespadilla.bsky.social for taking me on this ride. #PhDone 🎓
0160
Reposted by Mrinmoy
Deutsche Forschungsgemeinschaft @dfg.de · 12/05/2025
#LeibnizPreis für exzellente Forschung in der #Epigenetik: Welche Mechanismen liegen der Zellplastizität und Reprogrammierung von Zellen zugrunde? An der Antwort, die zukünftig bei der Heilung von Organen helfen könnte, arbeitet Maria-Elena Torres-Padilla @metorrespadilla.bsky.social. Gratulation!
0215
Reposted by Mrinmoy
Schuh Lab @schuhlab.bsky.social · 29/04/2025
We’re proud to announce #OvoLabs, co-founded by Melina @schuhlab.bsky.social, Agata Zielinska, and Oleksandr Yagensky. Building on decades of meiosis research, Ovo Labs aims to pioneer novel therapies to overcome the challenges of age-related infertility.
081
Reposted by Mrinmoy
Cell - a Cell Press journal @cp-cell.bsky.social · 23/04/2025
Now online! The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic pathways
dlvr.it
The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic pathways
In vivo screening in mouse embryos provides insights into the functional interplay between chromatin and the nuclear envelope in the establishment of lamina-associated domains, the earliest feature of nuclear organization following fertilization.
074
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
Thank you @anajaneva.bsky.social for sharing our work. You and IES are deeply missed! ❤️
000
Reposted by Mrinmoy
Helmholtz Munich @helmholtzmunich.bsky.social · 23/04/2025
How DNA Self-Organizes in the Early Embryo 🧬 The new insights challenge the classical model of genome organization & could lead to new disease treatments. 👉 t1p.de/25q7l @metorrespadilla.bsky.social @palmrinmoy.bsky.social @epihmgu.bsky.social @lmumuenchen.bsky.social
How DNA Self-Organizes in the Early Embryo
0103
Reposted by Mrinmoy
ME Torres-Padilla @metorrespadilla.bsky.social · 23/04/2025
Here is-🥳🥳😇 tremendous effort by @palmrinmoy.bsky.social brilliantly supported by @tamas-schauer.bsky.social &super help by federico,iliya,tsune,adam,@mamartirenom.bsky.social Very happy to see this come to fruition- Look forward to feedback from colleagues ! More 👉 www.cell.com/cell/fulltex...
37725
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
Read the press release on our work from @www.helmholtz-munich.de here: www.helmholtz-munich.de/en/epigeneti...
000
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
It has been an incredible journey in the @epihmgu.bsky.social community, with lots of discussions and advice. Also thanks to everyone who provided plasmid constructs for designing the screen and help with sequencing!
100
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
Grateful to all co-authors and collaborators who contributed their expertise, especially during the revisions! 🙏Thank you @mamartirenom.bsky.social for your guidance with the meta-analysis of the huge dataset.
100
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
🧬 This work is the result of a lot of hard work over 5 years of my PhD. Huge thanks to @metorrespadilla.bsky.social for trusting me with this challenging opportunity. Special mention to my bioinformatics buddy and plot wizard @tamas-schauer.bsky.social
210
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
n/n✨ In summary: LAD formation is epigenetically regulated, developmentally staged, and remarkably resilient!
100
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
9/n: Successful zygotic genome activation (ZGA) is typically associated with correct nuclear-lamina organization... ...but ZGA can occur even when lamina contacts are perturbed, especially at the resilient 2-cell stage.
100
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
8/n: Early embryos lack the constitutive heterochromatin pathway, including chromatin-compacting histone variants. This absence enables the non-canonical embryonic chromatin to co-exist with a unique and dynamic LAD organization not seen in differentiated cells.
100
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
7/n: We found that compartment boundaries constrain LAD disruption and serve as scaffolding cues for organizing the genome. LADs often spread only within B compartments, and LAD inversions follow compartment boundaries.
100
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
6/n:🧬 Even if LADs are disrupted in zygotes, embryos can rebuild LAD architecture at the 2-cell stage. BUT: Disruption at the 2-cell stage impairs preimplantation development.
100
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
5/n:🎯 H3K4me3 contributes to the robustness of nuclear organization. HP1 proteins anchor broad H3K9me3 domains to the lamina. But H3K4me3 acts as a barrier, a chromatin boundary that blocks excessive lamina binding. This balance is critical for correct nuclear organization.
100
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
4/n: We found that maternal inheritance of H3K27me3, not de novo methylation, is key to LAD formation in zygotes. 🎯 LAD establishment is maternally bookmarked and regulated through a PRC2–lamina antagonism.
100
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
3/n:💡 We discovered that chromatin pathways, not structural components, are the primary regulators of LADs in early embryos. The interplay of H3K9, H3K27, and H3K4 methylation is a major player in shaping genome-lamina contacts.
100
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
2/n: Using in vivo perturbation screening + simultaneous LAD mapping, we built a toolbox to explore how chromatin dynamics guide nuclear organization post-fertilization. 🧬 A glimpse into the genome's first "address book" at the beginning of life.
100
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
1/n: We reveal how chromatin pathways shape genome-lamina interactions in early mouse embryos, and what happens when they go wrong.
110
Mrinmoy @palmrinmoy.bsky.social · 23/04/2025
How does the genome find its place in the 3D space of the nucleus after fertilization? Out now @cellcellpress.bsky.social: cell.com/cell/fulltext/… 👇 A thread 👇
2418
Reposted by Mrinmoy
Genes & Development @genesdev.bsky.social · 22/04/2025
In this study, Hermant et al. describe the evolution of the retrotransposon MERVL and its cis-regulatory transcription factor binding motifs, highlighting the phyloregulatory adaptation at play during early embryogenesis. Learn more here: ➡️ tinyurl.com/gd352270
02715
Mrinmoy @palmrinmoy.bsky.social · 21/04/2025
🚨New paper alert! RIF1 as a key in vivo regulator of replication timing consolidation during early mammalian development. Another great collaborative effort from my time in the @metorrespadilla.bsky.social lab. Excited to see this one out!!
260
Reposted by Mrinmoy
ME Torres-Padilla @metorrespadilla.bsky.social · 10/04/2025
we've put a Review together 👇 Just came out at www.nature.com/articles/s41... hoping it is useful for those in the field but also for those not in the field who would like an overview on chromatin/epigenetics/replication/nuclear organisation in early embryos Enjoy :) - feedback welcome
25618
Reposted by Mrinmoy
Helmholtz Munich @helmholtzmunich.bsky.social · 20/03/2025
#LeibnizPrize 2025: Celebrating Excellence!🎉 👏Yesterday, Prof. Maria-Elena Torres-Padilla officially received the Gottfried Wilhelm Leibniz Prize from the German Research Foundation (DFG)! 👉 t1p.de/s6uma 🎥Watch her portrait: t1p.de/a30vo @metorrespadilla.bsky.social @dfg.de #LeibnizPreis
t1p.de
Maria-Elena Torres-Padilla - Gottfried Wilhelm Leibniz-Preisträgerin 2025 im Portrait
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
14113
Reposted by Mrinmoy
Siegel Lab @siegel-lab.bsky.social · 12/03/2025
If you are interested in antigenic variation, you may have wondered how parasites ‘select’ which antigen to express next. Our manuscript, just published in Nature, provides some answers! www.nature.com/articles/s41... @lmumuenchen.bsky.social @erc.europa.eu a.eu @nature.com
23611
Reposted by Mrinmoy
Epigenetics at Helmholtz Munich @epihmgu.bsky.social · 06/03/2025
🚨New Paper Alert! Check the news about the sucessful research led by our Director at IES here: 👉 t1p.de/d87p5. Original paper at @genesdev.bsky.social: genesdev.cshlp.org/content/earl... Congrats to Clara Hermant, Michel Mourra-Diaz, @marliesoomen.bsky.social, Mrinmoy Pal & rest of authors!
085
Reposted by Mrinmoy
Helmholtz Munich @helmholtzmunich.bsky.social · 06/03/2025
SRF: A New Regulator of Retrotransposons and Early Embryonic Genes🧬 A team led by Prof. Maria-Elena Torres-Padilla, #HelmholtzMunich, has uncovered a key player in early embryonic development: SRF. 👉 t1p.de/d87p5 @metorrespadilla.bsky.social @epihmgu.bsky.social #EmbryonicDevelopment #Epigenetics
SRF: A New Regulator of Retrotransposons and Genes in Early Embryonic Development
065
Reposted by Mrinmoy
Marlies Oomen @marliesoomen.bsky.social · 20/01/2025
Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex... A short thread to highlight some of our findings 🧵
711351
Reposted by Mrinmoy
Meghana Oak @meghana-oak.bsky.social · 22/01/2025
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨ 📄 Check it out here:
doi.org/10.1101/2025... 👇 Highlights below
doi.org
H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...
14719
Reposted by Mrinmoy
Epigenetics at Helmholtz Munich @epihmgu.bsky.social · 21/01/2025
🚨New paper alert, at Cell Press! 🚀 Excited to share groundbreaking research from Helmholtz Munich led by @metorrespadilla.bsky.social; @marliesoomen.bsky.social & @diego-rt.bsky.social. They've uncovered ancient viral DNA's role in early embryonic development! 👉 Original paper: shorturl.at/D7eCz
shorturl.at
An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development
Transcriptional activation of the embryonic genome (EGA) is a major developmental landmark enabling the embryo to become independent from maternal con…
0147