T cells are a key part of the adaptive immune system. Using their surface-bound T cell antigen receptors (TCRs), these cells scan peptides and other antigens presented to them by major histocompatibil...

UNIQplus is aimed at talented undergraduates from under-represented groups, who would find continuing into postgraduate study a challenge for reasons other than their academic ability. This section

Hydrogen-Deuterium Exchange Mass-Spectrometry (HDX-MS) is a powerful method to study protein conformational dynamics, but peptide-level measurements obscure residue-level detail. The authors present R...

In August 2024, the World Health Organization declared the mpox orthopoxvirus to be a Public Health Emergency of International Concern for the second time in...

Despite remarkable advances in computational methods, pre-clinical drug discovery continues to grapple with rising timelines and costs. Software, data, and automation are more powerful than ever, a...

Sagie et al. identify a KRAS.G12V-specific TCR and show that lymphodepleting chemotherapy enhances antigen presentation via immunoproteasome activation and HLA-I upregulation. Together, these changes ...

AbstractSummary. Computational methods to guide early-stage TCR drug discovery and TCR repertoire informatics currently under-utilize solved and predicted

Roger Highfield, Science Director, reports on an AI discussion at the Bradford Science Festival.

Fragment screens provide an information-rich starting point for designing derivative compounds that recapitulate key protein-ligand interactions in structure-based drug discovery. Maximizing the compo...

The State of AI Report analyses the most interesting developments in AI. Read and download here.

In developing therapeutic antibodies, the heavy chain is often prioritised due to its higher variability and its central role in antigen binding. An appropriate pairing of the light sequence is howeve...

While conventional Transformers generally operate on sequence data, they can be used in conjunction with structure models, typically SE(3)-invariant or equivariant graph neural networks (GNNs), for...

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Professor Charlotte Deane MBE (1993, Chemistry) is a Professor in the Department of Statistics at the University of Oxford and the...