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Reposted by @haroldgrosjean.bsky.social

Phil Biggin @philbiggin.bsky.social · 06/03/2026

Finally, the fully-typeset version of @haroldgrosjean.bsky.social's review "Developments and challenges in hit progression within fragment-based drug discovery" is online www.nature.com/articles/s41.... Congratulations Harold! @oxfordbiochemistry.bsky.social

nature.com

Developments and challenges in hit progression within fragment-based drug discovery - Nature Communications

This review maps key bottlenecks in turning fragment hits into lead compounds and highlights emerging solutions: integrated Design-Make-Test cycles, high-throughput assays, automation and modelling to...

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haroldgrosjean.bsky.social @haroldgrosjean.bsky.social · 13/01/2026

Happy to share our @chemicalscience.rsc.org paper where we extract a SAR model from HT crystallographic readouts of fragment elaborations in crude reaction mixtures! Thanks to @kate-fieseler.bsky.social for co-writing and @philbiggin.bsky.social! doi.org/10.1039/D5SC... #MyFirstChemSci #FBDD #D2B

lnkd.in

This link will take you to a page that’s not on LinkedIn

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haroldgrosjean.bsky.social @haroldgrosjean.bsky.social · 28/05/2025

🚨New preprint We extract structure–activity relationships (xSAR) directly from HT crystallography of crude reaction mixtures ⚡No hit resynthesis = faster DMTA 📄 doi.org/10.26434/che... @oxfordbiochemistry.bsky.social @diamondlightsource.bsky.social @opig.stats.ox.ac.uk @philbiggin.bsky.social #FBDD

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haroldgrosjean.bsky.social @haroldgrosjean.bsky.social · 19/03/2025

🚨 Binding-Site Purification of Actives 🦾 With robotic chemistry, automated QC & HT crystallography, we skip purification for faster, greener, cheaper SAR and DMTA-cycles! 🔗 doi.org/10.1002/anie... Thanks to @diamondlightsource.bsky.social @oxfordbiochemistry.bsky.social & co!

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