Sign in

Oliver Grant

@olivercgrant.bsky.social
131 followers 155 following 6 posts

Research Scientist doing glycomaterial and glycoprotein molecular modeling. I also develop the glyco webtools for www.glycam.org

PostsRepliesMedia
Reposted by Oliver Grant
Daniel Bojar @dbojar.bsky.social · 12/05/2025
A few GlycoDraw-related highlights of the upcoming glycowork v1.6 update (dropping in a few weeks): - our very own rendering engine (GlycoDraw for the masses, thanks to glycorender!); - SNFG-gradients; - automated Alt text; - reverse-highlighting; - even more support for highly complex sequences
2148
Oliver Grant @olivercgrant.bsky.social · 09/05/2025
After 20 years and a recent big overhaul we're finally publishing the carbohydrate 3D structure builders on GLYCAM-Web (glycam.org)! Pre-print: (www.biorxiv.org/content/10.1...) #glycotime tools
biorxiv.org
Generating 3D Models of Carbohydrates with GLYCAM-Web
The carbohydrate 3D structure-prediction tools (builders) at GLYCAM-Web (glycam.org) are widely used for generating experimentally-consistent 3D structures of oligosaccharides suitable for data interp...
142
Reposted by Oliver Grant
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 07/05/2025
Nice #glycotime review that pulls together the emerging story of glycosyltransferase specificity for cellular substrates chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com
Glycoproteins, Glycolipids, or Both: Why do Glycosyltransferases Recognize Different Acceptors?
Glycosylation is an important post-translational modification catalyzed by glycosyltransferases (GTs), which comprise a large group of enzymes with diversified specificity. Most GTs show high specifi...
14816
Reposted by Oliver Grant
Daniel Hurdiss @danielhurdiss.bsky.social · 02/05/2025
"A MERS-CoV-like mink coronavirus uses ACE2 as entry receptor" www.nature.com/articles/s41...
nature.com
A MERS-CoV-like mink coronavirus uses ACE2 as entry receptor - Nature
Nature - A MERS-CoV-like mink coronavirus uses ACE2 as entry receptor
023
Reposted by Oliver Grant
Robert de Vries @rpdevrieslab.bsky.social · 17/03/2025
I have a PhD position open in my lab! viruses and glycans... who does not love that combo😉. Please share!. #glycotime #lovevirology www.uu.nl/en/organisat...
uu.nl
PhD Position in Virus-Glycan Interactions
If you're ready to solve virus-glycan interaction puzzles and shape the future of novel in vitro models, join us!
02215
Reposted by Oliver Grant
Peng Wu @pengwu.bsky.social · 16/01/2025
Polysialic acids are upregulated on activated T cells #glycotime
biorxiv.org
Polysialylation is a general feature of immune activation
Sialic acids are critical regulators of immune responses and the sialic acid-Siglec axis has receive much attention recently for it role as a new immune checkpoint. While α2,3- and α2,6-linked sialosi...
082
Reposted by Oliver Grant
Andrew G. York @andrewgyork.bsky.social · 22/11/2024
MagLOV! MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social. We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!). bsky.app/profile/addg...
320372
Reposted by Oliver Grant
Robert de Vries @rpdevrieslab.bsky.social · 13/01/2025
We have a new preprint on the receptor specificity of 2.3.4.4 H5 viruses. We introduced the hallmark Q226L mutation in several antigenic backgrounds and observed different phenotypes. #H5N1 #glycotime www.biorxiv.org/content/10.1...
biorxiv.org
The Q226L mutation can convert a highly pathogenic H5 2.3.4.4e virus to bind human-type receptors
H5Nx viruses continue to wreak havoc in avian and mammalian species worldwide. The virus distinguishes itself by the ability to replicate to high titers and transmit efficiently in a wide variety of h...
12110
Oliver Grant @olivercgrant.bsky.social · 18/12/2024
Figure 3 needs a strobe effect warning. I find deducing carbohydrate structure from ChemDraw images hard enough, I don't need this! journals.asm.org/doi/10.1128/...
journals.asm.org
Surface Structures of Group B Streptococcus Important in Human Immunity | Microbiology Spectrum
ABSTRACTThe surface of the Gram-positive opportunistic pathogen Streptococcus agalactiae, or group B Streptococcus (GBS), harbors several carbohydrate and protein antigens with the potential to be eff...
000